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All Journal Jurnal EduHealth Media Farmasi Indonesia Jurnal Mahasiswa Ilmu Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Ihsanti Dwi Rahayu
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Formulation and Characteristics of Hydrogel Patch Containing Pineapple Peel (Ananas comosus L.) Ethanol Extract Anisah Putri Yuana Sari; Putik Titian Citra Hening; Marshanda Nikita; Ahmad Maulana Al Fatah; Fajrina Rizqi Riyadi; Ihsanti Dwi Rahayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.296

Abstract

Abstract Pineapple peel (Ananas comosus L.) contains bioactive compounds such as flavonoids and the enzyme bromelain, which possess antioxidant, anti-inflammatory, antibacterial, and anticancer properties, and the ability to accelerate wound healing. Hydrogel patches, as a formulation for transdermal delivery, are effective in wound healing due to their hydrophilic properties that maintain moisture and prevent bacterial infection in open wounds. This study aims to develop and test the characteristics of hydrogel patch formulations containing ethanol extracts of pineapple peel with varying concentrations of 10%, 20%, and 30%, compared to a control (hydrogel patch without pineapple peel extract). A series of evaluation tests were conducted to assess the patch characteristics, including organoleptic tests, pH, absorbency, weight uniformity, swelling ratio, patch thickness, and folding endurance. The results showed that the concentration of pineapple peel extract affects the hydrogel patch characteristics. The higher the extract concentration, the darker the patch color, but the pH, absorbency, and swelling ratio decrease. Patches with higher extract concentrations also showed an increase in weight. Absorbency tests indicated that none of the formulas met the acceptance criteria (<10%), with absorbency results of 22.97%, 11.60%, and 21.95% for 10%, 20%, and 30% extract concentrations, respectively, and 23.43% for the control. Swelling ratio and thickness tests showed the best results for the control, followed by the 10%, 20%, and 30% extract concentrations. The folding endurance test showed that the control and 10% extract formula had good results (>300 folds), while higher extract concentrations reduced the folding endurance of the hydrogel patch .Keywords: extract, pineapple peel, hydrogel patch, formulation, patch characteristics
Development of Pineapple Skin Extract Hydrogel Patch Applications (Ananas comosus L.) as Wound Dressing in Diabetic Ulcers in Mice (Mus musculus) Putik Titian Citra Hening; Anisah Putri Yuana Sari; Marshanda Nikita; Ahmad Maulana Al Fatah; Fajrina Rizqi Riyadi; Ihsanti Dwi Rahayu
Media Farmasi Indonesia Vol. 19 No. 2 (2024): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v19i2.297

Abstract

Abstrak Diabetes melitus merupakan penyakit gangguan metabolisme kronis yang disebabkan oleh tingginya kadar glukosa darah. Salah satu komplikasi yang sering terjadi pada penderita diabetes melitus adalah ulkus diabetikum. Penelitian menunjukkan bahwa kulit nanas mengandung flavonoid, yaitu senyawa aktif yang bersifat antiinflamasi dan antimikroba, yang dapat mempercepat penyembuhan luka. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian patch hidrogel yang mengandung ekstrak kulit nanas (Ananas comosus L.) sebagai pembalut luka pada tikus putih (Mus musculus) jantan yang mengalami ulkus diabetikum. Penelitian ini melibatkan beberapa tahap, meliputi ekstraksi kulit nanas, pembuatan patch hidrogel, uji aktivitas antibakteri, dan pemberian patch hidrogel pada hewan uji. Penelitian ini menggunakan 20 ekor tikus putih jantan galur Deutschland Denken Yoken (DDY) yang dibagi menjadi 5 kelompok. Kelompok kontrol negatif mendapat patch hidrogel tanpa ekstrak, sedangkan kelompok kontrol positif mendapat Winner Hydrocolloid Dressing. Kelompok perlakuan I, II, dan III masing-masing diberi patch hidrogel dengan ekstrak kulit nanas 10%, 20%, dan 30%. Hasil penelitian menunjukkan bahwa plester hidrogel dengan ekstrak kulit nanas mempercepat penyembuhan luka pada model ulkus diabetik. Uji aktivitas antibakteri menunjukkan aktivitas antimikroba yang signifikan terhadap Staphylococcus aureus, yang umum ditemukan pada ulkus diabetik. Aplikasi plester hidrogel mengurangi peradangan dan memperbaiki struktur jaringan kulit pada hewan uji, menunjukkan potensi plester hidrogel ekstrak kulit nanas sebagai pembalut luka alternatif yang efektif untuk ulkus diabetik. Kata kunci: ulkus diabetikum, ekstrak kulit nanas, patch hidrogel, pembalut luka
Kandungan Senyawa Fitokimia dan Aktivias Antioksidan dari Ekstrak Daun Alpukat (Persea americana Mill.) : Narrative Review Michelle Jovelyna My Angel Pasaribu; Ihsanti Dwi Rahayu; Muhammad Iqbal; Ari Sri Ulandari
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i2.597

Abstract

Avocado leaves have long been used by Indonesian people as traditional medicine. Many studies have shown that the plant has many active compounds that have the potential to prevent cell damage caused by free radicals. The purpose of this narrative review article is to collect and review references related to the phytochemical compound content and potential antioxidant activity of avocado leaf extract (Persea americana Mill.). The search and review of literature used in writing this article was carried out by searching for reference sources by combining relevant keywords such as "antioxidant AND persea americana leaves* AND extract" on database sites such as NCBI, ScienceDirect, and Google Scholar. There are inclusion criteria used, namely articles in English and Indonesian, available in full text form, discussing secondary metabolite compounds of avocado leaf extract using the maceration method, and discussing antioxidant activity tests using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Based on the search results, there are 7 articles that have met the inclusion criteria and have been reviewed. The results of this narrative review obtained information that there were several studies that conducted antioxidant activity tests on avocado leaf extract using the DPPH method with an IC50 value range of 6.7-440.80 µg/ml and there were polyphenol compounds, especially quercetin and kaempferol which contributed to the antioxidant activity of avocado leaves.
Kandungan Senyawa Fitokimia dan Aktivitas Antibakteri Ekstrak Daun Pepaya (Carica Papaya L.): Narrative Review Umniyah Tsabitah Zahrani; Ihsanti Dwi Rahayu; Atri Sri Ulandari; Ramadhan Triyandi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i2.599

Abstract

This narrative review article explores the potential of papaya leaves (Carica papaya L.) as an alternative antibacterial treatment due to the increasing problem of antibiotic resistance. Papaya leaves, commonly found in Indonesia, are known to have various pharmacological properties, including antibacterial effects. The article aims to collect and review existing literature on the phytochemical compounds and antibacterial activity of papaya leaf extract. Literature searches were conducted across several databases such as Google Scholar, NCBI, ResearchGate, and ScienceDirect using keywords like "antibacterial," "phytochemical screening," and "Carica papaya leaf." Articles from the last five years that were accessible in full text and relevant to the topic were selected, leading to the inclusion of 18 articles in the review.The findings indicate that papaya leaf extracts exhibit antibacterial properties against both gram-positive and gram-negative bacteria. The degree of antibacterial activity varies, ranging from weak to very strong inhibition. This antibacterial effect is attributed to the secondary metabolite compounds present in papaya leaves, including alkaloids, flavonoids, saponins, tannins, phenolics, terpenoids, and steroids. These compounds contribute to the biological activity of the extract, making it a promising candidate for further development as a natural antibacterial agent. Overall, this review underscores the importance of exploring medicinal plants like papaya leaves as viable alternatives to combat bacterial infections and address the growing issue of antibiotic resistance..
Potensi Antibakteri Ekstrak Bulu Babi Diadema setosum dan Echinometra Mathaei : Literature Review Natalia Michelle Simatupang; Ramadhan Triyandi; Ihsanti Dwi Rahayu; Femmy Andrifianie; Muhammad Iqbal
Jurnal Mahasiswa Ilmu Kesehatan Vol. 3 No. 3 (2025): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v3i3.2744

Abstract

The increasing incidence of bacterial resistance to antibiotics has become one of the major challenges in global health, necessitating the exploration of natural antibacterial sources as alternative treatments, such as bioactive compounds derived from sea urchins. This literature review aims to evaluate the antibacterial potential of sea urchin extracts based on existing research findings. The literature search was conducted using the PubMed and Google Scholar databases using the Boolean operators (AND, OR). Inclusion criteria include articles published between 2014 and 2024, available in full text, written in either Indonesian or English, and discussing the antibacterial activity of sea urchin extracts from the species Diadema setosum and/or Echinometra mathaei. Based on the selection process, eight articles met the inclusion criteria and were included in the review. The results of the literature review indicate that sea urchin extracts exhibit antibacterial activity against gram-negative bacteria, including Escherichia coli, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, Pseudomonas aeruginosa, Aeromonas hydrophila, Acinetobacter sp., Citrobacter freundii, and Klebsiella pneumoniae, as well as gram-positive bacteria, including Propionibacterium acnes, Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Staphylococcus epidermidis, Streptococcus mutans, and Streptococcus sobrinus. These antibacterial effects are attributed to the presence of secondary metabolites such as alkaloids, steroids, flavonoids, saponins, and phenolics.
Patient Satisfaction with Pharmaceutical Services at the Outpatient Pharmacy Installation of Hospital X, Bandar Lampung City Yasmin Al Illyyin; Oktafany, Oktafany; Dwi Aulia Ramdini; Ihsanti Dwi Rahayu
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

As the main referral hospital in Lampung Province, evaluating the quality of pharmaceutical services at Hospital X is necessary. Periodic assessment of patient satisfaction is essential to maintain service quality in accordance with expectations. Therefore, this study aims to evaluate the level of patient satisfaction with pharmaceutical services at the Outpatient Pharmacy Installation of Hospital X in Bandar Lampung City. This study employed a cross-sectional survey design, with a purposive sampling technique applied to outpatients or their companions during April–May 2025. Data were collected using the SERVQUAL questionnaire, which consists of five dimensions: tangibility, reliability, responsiveness, assurance, and empathy. The instrument was tested for validity (r count > r table) and reliability (Cronbach's alpha ≥ 0.6), and was declared valid and reliable. The data were analyzed by calculating the gap between patients' expectations and perceptions for each service dimension. A total of 354 respondents expressed being very satisfied with the tangibility (85.3%), reliability (87.7%), assurance (84.1%), and empathy (82.5%) dimensions, and satisfied with the responsiveness dimension (75.8%). All dimensions showed negative gaps (−0.534), with the largest gap in responsiveness (−0.84), indicating a significant discrepancy between patient expectations and experiences. The smallest gap was in reliability (−0.36), indicating that this dimension was closest to meeting patient expectations. Overall, outpatient satisfaction with pharmaceutical services at the Pharmacy Installation of Hospital The responsiveness dimension has the highest gap and should be the primary focus for improvement in order to enhance service quality.
Co-Authors Ahmad Maulana Al Fatah Anisah Putri Yuana Sari Ari Sri Ulandari Atri Sri Ulandari DWi Aulia Ramdini Fajrina Rizqi Riyadi Femmy Andrifianie Marshanda Nikita Michelle Jovelyna My Angel Pasaribu Muhammad Iqbal Natalia Michelle Simatupang Oktafany, Oktafany Putik Titian Citra Hening Ramadhan Triyandi Umniyah Tsabitah Zahrani Yasmin Al Illyyin