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All Journal JURNAL KEDOKTERAN KOMUNITAS DAN TROPIK Malacca Pharmaceutics
Wungouw, Herlina Ineke Surjane
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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Identifikasi faktor resiko katarak pada pasien Poli Mata Rumah Sakit Gunung Maria Tomohon Pitoy, Gisela; Wungouw, Herlina Ineke Surjane; Polii, Hedison
Jurnal Kedokteran Komunitas dan Tropik Vol 12 No 2 (2024)
Publisher : UNIVERSITAS SAM RATULANGI

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Background: Cataract blindness has become a global health problem and must be solved immediately because blindness can affect the quality of life and productivity. In 2013-2017, a Rapid Assessment of Avoidable Blindness (RAAB) was conducted in 15 provinces in Indonesia, one of which is North Sulawesi. The survey showed that the main cause of visual impairment and blindness in the 15 provinces was untreated cataracts. Aim: To identify the dominant risk factors of cataract patients at the eye clinic of Gunung Maria Hospital Tomohon. Methods: This is descriptive-analytic research with a cross-sectional study design using questionnaires and direct interviews. The research consisted of 40 samples for the inclusion and exclusion. Result: The result showed there were a total of 40 cataract patients, 29 patients aged >60 years (72.5%) and 11 patients aged <60 years (27.5%). According to gender, there were 21 male cataract patients (52.5%) and 19 female cataract patients (47.5%). Based on smoking history, 17 patients smoked (42.5%) and 23 patients who did not smoke (57.5%). Based on the duration of sun exposure, 12 patients were daily exposed to sunlight for <5 hours (30%) and 28 patients were daily exposed to sunlight for >5 hours (70.0%). Based on the history of lens trauma, seven patients had a history of lens trauma (17.5%), and 33 patients did not have a history of lens trauma (82.5%). Conclusion: The dominant risk factors for cataract patients in the eye clinic of The Gunung Maria Hospital Tomohon are the age factors >60 years and patients who were exposed to sunlight for >5 hours daily. Keywords: cataract, risk factors
Appraisal of Antioxidant Potential in Broccoli Microgreens under Different Drying Techniques Utilizing In Vitro and in Silico Methods Tallei, Trina Ekawati; Wungouw, Herlina Ineke Surjane; Kepel, Billy Johnson; Fatimawali, Fatimawali; Celik, Ismail; Niode, Nurdjannah Jane; Barasarathi , Jayanthi
Malacca Pharmaceutics Vol. 3 No. 1 (2025): March 2025
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v3i1.259

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Broccoli microgreens, rich in bioactive compounds, offer health benefits aligned with SDG 3: “Good Health and Well-Being.” Their antioxidants combat oxidative stress tied to chronic diseases, but drying can affect their activity. This study assessed the antioxidant capacities of fresh, microwave-dried, and air-fryer-dried broccoli microgreens using in vitro (DPPH assay) and in silico (molecular docking and dynamics) methods. The microgreens were cultivated under controlled conditions and dried using microwave and air-fryer techniques. Antioxidant activity was evaluated using the DPPH assay using ethanolic extracts. The bioactive compounds of fresh microgreens, detected through GC-MS, were analyzed in silico to evaluate their interactions with the target proteins CYP2C9 and NOX2. The findings revealed that air-fryer-dried microgreens demonstrated the highest DPPH activity, followed by fresh microgreens, while microwave-dried samples exhibited the lowest activity. GC-MS analysis of fresh samples revealed the presence of various compounds, including acids, ketones, sulfides, heterocycles, alcohols, esters, aromatic compounds, phthalate ester, and aldehydes. Molecular docking revealed strong interactions of certain compounds in fresh samples and CYP2C9 and NOX2, suggesting therapeutic potential against oxidative stress. Molecular dynamics simulations (MDS) showed stable binding for the CYP2C9-Methyl myristate complex, while the NOX-(Z)-1,2-Diphenylethene complex displayed weaker stability. In conclusion, broccoli microgreens show potential in mitigating oxidative stress, with air-fryer drying slightly enhancing their antioxidant activity. The antioxidant capacity of fresh microgreens is comparable to that of air-fryer-dried microgreens. In silico analyses demonstrate stable interactions between compounds in fresh microgreens and key proteins implicated in oxidative stress.
Co-Authors Barasarathi , Jayanthi Celik, Ismail Fatimawali . Hedison Polii Kepel, Billy Johnson Niode, Nurdjannah Jane Pitoy, Gisela TRINA EKAWATI TALLEI