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All Journal Sriwijaya Journal of Neurology Sriwijaya Journal of Otorhinolaryngology
Johan Wirahadi Putro
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Public Health

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Proteomic Analysis of Saliva in Patients with Oral Squamous Cell Carcinoma: Identifying Diagnostic and Prognostic Biomarkers in Indonesia Rachmat Hidayat; Johan Wirahadi Putro; Arsan Saliha
Sriwijaya Journal of Otorhinolaryngology Vol. 1 No. 2 (2023): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i1.31

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) is a significant health problem in Indonesia, characterized by high morbidity and mortality rates. Early detection is critical for improving patient outcomes. Saliva, a readily accessible biofluid, holds promise as a non-invasive source for identifying biomarkers for OSCC diagnosis and prognosis. This study aimed to identify salivary proteomic biomarkers associated with OSCC in an Indonesian population. Methods: Saliva samples were collected from 50 OSCC patients and 50 healthy controls. Proteomic analysis was performed using liquid chromatography-mass spectrometry (LC-MS/MS). Differentially expressed proteins were identified and validated using enzyme-linked immunosorbent assays (ELISA). Bioinformatic analysis was conducted to explore the functional roles and pathways associated with identified biomarkers. Results: LC-MS/MS analysis revealed 100 differentially expressed proteins in the saliva of OSCC patients compared to controls. After validation by ELISA, five proteins consistently showed significant differences: Increased levels of S100A7, MUC5B, and IL-6, and decreased levels of Statherin and Histatin 1 were observed in OSCC patients. Conclusion: This study identified a panel of salivary protein biomarkers with potential for OSCC diagnosis and prognosis in the Indonesian population. Further validation in larger cohorts is needed to assess their clinical utility and develop potential screening tools.
The Role of the Vestibular System in Balance Disorders and Falls in the Elderly: A Prospective Cohort Study with Posturography Assessment in Surabaya, Indonesia Venny Melinda; Johan Wirahadi Putro; Mariana Alifah; Michelle Birne; Abhimanyu Putra
Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i2.82

Abstract

Introduction: Falls in the elderly represent a significant public health concern, often leading to injury, disability, and reduced quality of life. The vestibular system plays a crucial role in maintaining balance, and its decline with age is a major contributor to falls. This study aimed to investigate the relationship between vestibular function, assessed through posturography, and the incidence of falls in elderly individuals in Surabaya, Indonesia. Methods: A prospective cohort study was conducted involving 150 participants aged 60 years and above residing in Surabaya. Baseline assessments included a comprehensive geriatric assessment, vestibular function tests using computerized dynamic posturography (CDP), and questionnaires on falls history. Participants were followed up for 12 months to record the occurrence of falls. Data analysis included descriptive statistics, correlation analysis, and logistic regression to identify predictors of falls. Results: The incidence of falls during the 12-month follow-up period was 32%. CDP revealed significant age-related decline in vestibular function, particularly in measures of sensory organization and balance strategy. Poor performance on CDP, especially in conditions with altered visual and proprioceptive inputs, was significantly associated with an increased risk of falls. History of previous falls, presence of comorbidities, and use of polypharmacy were also identified as significant predictors of falls. Conclusion: Vestibular dysfunction, as assessed by CDP, is a significant risk factor for falls in the elderly. Incorporating posturography assessment into routine geriatric evaluations may help identify individuals at high risk of falls, allowing for targeted interventions to prevent falls and associated complications.
Co-Authors Abhimanyu Putra Arsan Saliha Mariana Alifah Michelle Birne Rachmat Hidayat Venny Melinda