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All Journal Scientific Journal of Pediatrics Sriwijaya Journal of Internal Medicine Sriwijaya Journal of Neurology Crown: Journal of Dentistry and Health Research Sriwijaya Journal of Otorhinolaryngology
Zainal Abidin Hasan
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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A Comparative Study of Intranasal Corticosteroids versus Antihistamines in the Management of Persistent Allergic Rhinitis in Indonesia Mariana Alifah; Abhimanyu Putra; Zainal Abidin Hasan; Aisyah Andina Rasyid; Sari Sulistyoningsih
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.92

Abstract

Introduction: Allergic rhinitis (AR) is a prevalent chronic inflammatory disease in Indonesia. Intranasal corticosteroids (INCS) and antihistamines are commonly prescribed treatments, but their comparative effectiveness in the Indonesian context remains unclear. This study aimed to compare the efficacy and safety of INCS versus antihistamines in managing persistent AR in Indonesia. Methods: A randomized controlled trial was conducted involving 120 patients diagnosed with persistent AR according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Participants were randomly assigned to receive either INCS (fluticasone propionate) or oral antihistamines (cetirizine) for eight weeks. The primary outcome was the change in the Total Nasal Symptom Score (TNSS), and secondary outcomes included the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score and adverse events. Results: Both INCS and antihistamines significantly improved TNSS and RQLQ scores from baseline. However, the INCS group demonstrated a significantly greater reduction in TNSS scores compared to the antihistamine group (p<0.05) at weeks 4 and 8. No significant difference was found between the two groups in terms of RQLQ score improvement. Both treatments were well-tolerated, with mild and transient adverse events reported in both groups. Conclusion: INCS are more effective than antihistamines in controlling nasal symptoms in patients with persistent AR in Indonesia. Both treatments improve quality of life, with comparable safety profiles. These findings support the preferential use of INCS as first-line therapy for persistent AR in the Indonesian population.
Transcranial Magnetic Stimulation for the Treatment of Chronic Dizziness: A Randomized Controlled Trial in Bandung, Indonesia Zahra Amir; Nabila Saraswati; Made Swastika; Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Bernadette Wilson
Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i2.90

Abstract

Introduction: Chronic dizziness is a debilitating condition with limited treatment options. Transcranial magnetic stimulation (TMS) has shown promise in treating various neurological conditions. This randomized controlled trial investigated the efficacy and safety of TMS in treating chronic dizziness in Bandung, Indonesia. Methods: Participants with chronic dizziness (≥ 3 months) were randomly assigned to receive either active TMS or sham TMS for 10 sessions over two weeks. The active TMS group received 1 Hz stimulation over the right dorsolateral prefrontal cortex (DLPFC), while the sham group received placebo stimulation. The primary outcome was the change in Dizziness Handicap Inventory (DHI) score from baseline to four weeks post-intervention. Secondary outcomes included changes in Vertigo Symptom Scale (VSS) scores, Hospital Anxiety and Depression Scale (HADS) scores, and quality of life measures. Safety was assessed through monitoring of adverse events. Results: A total of 60 participants completed the study (30 in each group). The active TMS group showed a significantly greater improvement in DHI scores compared to the sham group (p < 0.001). Significant improvements were also observed in VSS, HADS, and quality of life measures in the active TMS group. No serious adverse events were reported. Conclusion: This study provides evidence for the efficacy and safety of TMS in treating chronic dizziness in the Indonesian population. TMS may be a valuable therapeutic option for patients with chronic dizziness who have not responded to conventional therapies.
Influence of Preparation Design on the Fracture Resistance of Endodontically Treated Teeth Restored with Full-Coverage Crowns in Jakarta, Indonesia Alexander Mulya; Nabila Saraswati; Serena Jackson; Made Swastika; Zainal Abidin Hasan
Crown: Journal of Dentistry and Health Research Vol. 1 No. 2 (2023): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v1i2.89

Abstract

Introduction: Endodontically treated teeth are more susceptible to fracture due to the loss of tooth structure and moisture. Full-coverage crowns are often used to restore these teeth and enhance their fracture resistance. However, the influence of different preparation designs on the fracture resistance of endodontically treated teeth remains a topic of investigation. This study aimed to evaluate the fracture resistance of endodontically treated teeth restored with full-coverage crowns with different preparation designs in Jakarta, Indonesia. Methods: Forty extracted human premolars were endodontically treated and divided into four groups (n=10): Group 1: Butt-joint margin with a 1 mm chamfer finish line; Group 2: Shoulder margin with a 1.5 mm chamfer finish line; Group 3: Deep chamfer margin with a 2 mm chamfer finish line; and Group 4: Shoulder margin with a rounded shoulder finish line. All teeth were prepared for full-coverage crowns and restored with standardized metal-ceramic crowns. A universal testing machine was used to apply compressive load to the teeth until fracture. The fracture resistance values were recorded in Newtons (N) and analyzed using one-way ANOVA and Tukey's post-hoc test (α=0.05). Results: The mean fracture resistance values (N) were as follows: Group 1 (1250 ± 150), Group 2 (1480 ± 180), Group 3 (1180 ± 130), and Group 4 (1550 ± 200). One-way ANOVA revealed significant differences in fracture resistance among the groups (p<0.05). Tukey's post-hoc test indicated that Group 4 exhibited significantly higher fracture resistance than Group 1 and Group 3 (p<0.05). Group 2 also demonstrated significantly higher fracture resistance than Group 3 (p<0.05). Conclusion: Within the limitations of this study, the shoulder margin with a rounded shoulder finish line provided the highest fracture resistance for endodontically treated teeth restored with full-coverage crowns. The butt-joint margin and deep chamfer margin preparations exhibited lower fracture resistance.
Predictive Value of Drug-Induced Sleep Endoscopy (DISE) in Pediatric Obstructive Sleep Apnea: A Multicenter Cohort Study in Indonesia Sarah Istiqomah; Annisa Annisa; Dessy Agustina; Abhimanyu Putra; Zainal Abidin Hasan; Johan Wirahadi Putro; Venny Melinda; Nabila Saraswati; Made Swastika
Scientific Journal of Pediatrics Vol. 3 No. 1 (2025): Scientific Journal of Pediatrics
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjped.v2i2.174

Abstract

Introduction: Obstructive sleep apnea (OSA) is a significant pediatric health concern in Indonesia, but diagnostic and treatment pathways are often resource-constrained. Drug-induced sleep endoscopy (DISE) offers a dynamic assessment of upper airway obstruction, but its predictive value for treatment outcomes in Indonesian children remains unclear. This study aimed to evaluate the predictive value of DISE findings for polysomnography (PSG)-determined OSA severity and surgical outcomes in a multicenter cohort of Indonesian children. Methods: A prospective, multicenter cohort study was conducted at three tertiary hospitals in Indonesia. Children aged 2-18 years with suspected OSA underwent DISE and overnight PSG. DISE findings were classified using the VOTE (Velum, Oropharynx, Tongue base, Epiglottis) classification system. The primary outcome was the correlation between DISE findings and the apnea-hypopnea index (AHI) on PSG. Secondary outcomes included the prediction of surgical success (defined as a postoperative AHI < 5 and >50% reduction from baseline) after adenotonsillectomy (T&A). Statistical analyses included Spearman's rank correlation, receiver operating characteristic (ROC) curve analysis, and logistic regression. Results: 250 children (mean age 8.2 ± 3.5 years, 60% male) were included. A significant positive correlation was found between the total VOTE score and AHI (ρ = 0.62, p < 0.001). Tongue base obstruction (VOTE-T) showed the strongest correlation with AHI (ρ = 0.58, p < 0.001). The area under the ROC curve (AUC) for the total VOTE score predicting severe OSA (AHI ≥ 10) was 0.85 (95% CI, 0.79-0.91). In the subgroup of 180 children who underwent T&A, a higher total VOTE score (particularly VOTE-T and VOTE-E scores) was significantly associated with a lower likelihood of surgical success (OR 0.45, 95% CI 0.28-0.72, p = 0.001). Conclusion: DISE, using the VOTE classification, demonstrates good predictive value for OSA severity and surgical outcomes in Indonesian children. Tongue base and epiglottic obstruction are particularly important predictors. DISE can be a valuable tool for guiding treatment decisions in resource-limited settings.
The Impact of Uncontrolled Type 2 Diabetes Mellitus on Chronic Rhinosinusitis Severity and Treatment Outcomes: A Prospective Cohort Study in Bandung, Indonesia Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Alexander Mulya; Pham Uyen; Maria Rodriguez
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.176

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition, and type 2 diabetes mellitus (T2DM) is a known comorbidity that can exacerbate inflammatory processes. This study aimed to investigate the impact of uncontrolled T2DM on CRS severity and treatment outcomes in a cohort of patients in Bandung, Indonesia. Methods: A prospective cohort study was conducted at a private hospital in Bandung, Indonesia, from January 2020 to December 2022. Adult patients diagnosed with CRS (with or without nasal polyps) were enrolled and categorized into two groups: controlled T2DM (HbA1c ≤ 7%) and uncontrolled T2DM (HbA1c > 7%). CRS severity was assessed using the Sino-Nasal Outcome Test-22 (SNOT-22) and Lund-Mackay CT scoring. Treatment outcomes were evaluated at 3, 6, and 12 months post-initial treatment (medical and/or surgical) based on SNOT-22 scores, endoscopic findings, and the need for revision surgery. Results: A total of 240 patients were included (120 with controlled T2DM, 120 with uncontrolled T2DM). At baseline, the uncontrolled T2DM group had significantly higher mean SNOT-22 scores (58.5 ± 12.3 vs. 45.2 ± 10.1, p < 0.001) and Lund-Mackay CT scores (11.8 ± 3.5 vs. 8.2 ± 2.8, p < 0.001) compared to the controlled T2DM group. At 12 months, the uncontrolled T2DM group showed significantly less improvement in SNOT-22 scores (mean change: -15.4 ± 8.7 vs. -28.3 ± 9.2, p < 0.001) and a higher rate of revision surgery (18.3% vs. 5.8%, p = 0.002). Multivariate analysis revealed that uncontrolled T2DM (HbA1c > 7%) was an independent predictor of poorer treatment outcomes (OR: 3.45, 95% CI: 1.98-6.01, p < 0.001). Conclusion: Uncontrolled T2DM is associated with increased CRS severity and significantly poorer treatment outcomes in patients in Bandung, Indonesia. Effective glycemic control should be a crucial component of CRS management in patients with T2DM.
Co-Authors Abhimanyu Putra Aisyah Andina Rasyid Alexander Mulya Annisa Annisa Bernadette Wilson Dessy Agustina Hasrita Soleiman Johan Wirahadi Putro Made Swastika Maria Rodriguez Mariana Alifah Nabila Saraswati Pham Uyen Sarah Istiqomah Sari Sulistyoningsih Serena Jackson Venny Melinda Zahra Amir