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All Journal Sriwijaya Journal of Neurology Crown: Journal of Dentistry and Health Research Sriwijaya Journal of Otorhinolaryngology
Zainal Abidin Hasan
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Public Health

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A Comparative Study of Intranasal Corticosteroids versus Antihistamines in the Management of Persistent Allergic Rhinitis in Indonesia Mariana Alifah; Abhimanyu Putra; Zainal Abidin Hasan; Aisyah Andina Rasyid; Sari Sulistyoningsih
Sriwijaya Journal of Otorhinolaryngology Vol. 2 No. 1 (2024): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v1i2.92

Abstract

Introduction: Allergic rhinitis (AR) is a prevalent chronic inflammatory disease in Indonesia. Intranasal corticosteroids (INCS) and antihistamines are commonly prescribed treatments, but their comparative effectiveness in the Indonesian context remains unclear. This study aimed to compare the efficacy and safety of INCS versus antihistamines in managing persistent AR in Indonesia. Methods: A randomized controlled trial was conducted involving 120 patients diagnosed with persistent AR according to the Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines. Participants were randomly assigned to receive either INCS (fluticasone propionate) or oral antihistamines (cetirizine) for eight weeks. The primary outcome was the change in the Total Nasal Symptom Score (TNSS), and secondary outcomes included the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score and adverse events. Results: Both INCS and antihistamines significantly improved TNSS and RQLQ scores from baseline. However, the INCS group demonstrated a significantly greater reduction in TNSS scores compared to the antihistamine group (p<0.05) at weeks 4 and 8. No significant difference was found between the two groups in terms of RQLQ score improvement. Both treatments were well-tolerated, with mild and transient adverse events reported in both groups. Conclusion: INCS are more effective than antihistamines in controlling nasal symptoms in patients with persistent AR in Indonesia. Both treatments improve quality of life, with comparable safety profiles. These findings support the preferential use of INCS as first-line therapy for persistent AR in the Indonesian population.
Transcranial Magnetic Stimulation for the Treatment of Chronic Dizziness: A Randomized Controlled Trial in Bandung, Indonesia Zahra Amir; Nabila Saraswati; Made Swastika; Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Bernadette Wilson
Sriwijaya Journal of Neurology Vol. 2 No. 1 (2024): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i2.90

Abstract

Introduction: Chronic dizziness is a debilitating condition with limited treatment options. Transcranial magnetic stimulation (TMS) has shown promise in treating various neurological conditions. This randomized controlled trial investigated the efficacy and safety of TMS in treating chronic dizziness in Bandung, Indonesia. Methods: Participants with chronic dizziness (≥ 3 months) were randomly assigned to receive either active TMS or sham TMS for 10 sessions over two weeks. The active TMS group received 1 Hz stimulation over the right dorsolateral prefrontal cortex (DLPFC), while the sham group received placebo stimulation. The primary outcome was the change in Dizziness Handicap Inventory (DHI) score from baseline to four weeks post-intervention. Secondary outcomes included changes in Vertigo Symptom Scale (VSS) scores, Hospital Anxiety and Depression Scale (HADS) scores, and quality of life measures. Safety was assessed through monitoring of adverse events. Results: A total of 60 participants completed the study (30 in each group). The active TMS group showed a significantly greater improvement in DHI scores compared to the sham group (p < 0.001). Significant improvements were also observed in VSS, HADS, and quality of life measures in the active TMS group. No serious adverse events were reported. Conclusion: This study provides evidence for the efficacy and safety of TMS in treating chronic dizziness in the Indonesian population. TMS may be a valuable therapeutic option for patients with chronic dizziness who have not responded to conventional therapies.
Influence of Preparation Design on the Fracture Resistance of Endodontically Treated Teeth Restored with Full-Coverage Crowns in Jakarta, Indonesia Alexander Mulya; Nabila Saraswati; Serena Jackson; Made Swastika; Zainal Abidin Hasan
Crown: Journal of Dentistry and Health Research Vol. 1 No. 2 (2023): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v1i2.89

Abstract

Introduction: Endodontically treated teeth are more susceptible to fracture due to the loss of tooth structure and moisture. Full-coverage crowns are often used to restore these teeth and enhance their fracture resistance. However, the influence of different preparation designs on the fracture resistance of endodontically treated teeth remains a topic of investigation. This study aimed to evaluate the fracture resistance of endodontically treated teeth restored with full-coverage crowns with different preparation designs in Jakarta, Indonesia. Methods: Forty extracted human premolars were endodontically treated and divided into four groups (n=10): Group 1: Butt-joint margin with a 1 mm chamfer finish line; Group 2: Shoulder margin with a 1.5 mm chamfer finish line; Group 3: Deep chamfer margin with a 2 mm chamfer finish line; and Group 4: Shoulder margin with a rounded shoulder finish line. All teeth were prepared for full-coverage crowns and restored with standardized metal-ceramic crowns. A universal testing machine was used to apply compressive load to the teeth until fracture. The fracture resistance values were recorded in Newtons (N) and analyzed using one-way ANOVA and Tukey's post-hoc test (α=0.05). Results: The mean fracture resistance values (N) were as follows: Group 1 (1250 ± 150), Group 2 (1480 ± 180), Group 3 (1180 ± 130), and Group 4 (1550 ± 200). One-way ANOVA revealed significant differences in fracture resistance among the groups (p<0.05). Tukey's post-hoc test indicated that Group 4 exhibited significantly higher fracture resistance than Group 1 and Group 3 (p<0.05). Group 2 also demonstrated significantly higher fracture resistance than Group 3 (p<0.05). Conclusion: Within the limitations of this study, the shoulder margin with a rounded shoulder finish line provided the highest fracture resistance for endodontically treated teeth restored with full-coverage crowns. The butt-joint margin and deep chamfer margin preparations exhibited lower fracture resistance.
Co-Authors Abhimanyu Putra Aisyah Andina Rasyid Alexander Mulya Bernadette Wilson Hasrita Soleiman Made Swastika Mariana Alifah Nabila Saraswati Sari Sulistyoningsih Serena Jackson Zahra Amir