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All Journal Journal of Innovation Research and Knowledge Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Annisa Normiani Putri
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Humanities Dentistry Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Nursing Public Health Social Sciences Veterinary

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Review Artikel: Pengaruh Penggunaan Bahan Pengikat Alami dan Sintetis pada Kualitas Fisik Tablet Siti Nurhaliza; Nur Luthfia Salim; Annisa Normiani Putri; Lidya Syahjiah; Muhammad Dhaiffullah; Nor Latifah
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1946

Abstract

Tablets are one of the most preferred forms of medication due to their compact shape, portability, and good stability. A key factor that greatly influences the physical quality of tablets is the binder used. This article reviews various studies on the effects of using natural and synthetic binders on the physical quality of tablets in drug formulations, including PVC, HPMC, CMC-Na, jackfruit seed starch, banana heart starch, and white sweet potato starch, which contribute to forming tablets with optimal physical properties. Data on the use of tablet binders were collected through a literature study method. The results concluded that the use of PVC, HPMC, CMC-Na, jackfruit seed starch, banana heart starch, and white sweet potato starch binders have an impact on the physical properties of tablets.
Analisis Kompaaratif Stabilitas Kimia dan Fisika Paracetamol pada Sediaan Padat dan Cair Anisa Anisa; Annisa Normiani Putri; Nor Latifah
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.773

Abstract

Paracetamol is one of the most widely used analgesic-antipyretic drugs and is available in various formulations, including solid tablets and liquid syrups, which differ significantly in long-term stability. This review analyzes data from ten journal studies (2013–2024) comparing the stability of paracetamol in different dosage forms. A literature review method was employed to assess physical and chemical stability under various storage conditions. Solid dosage forms, such as tablets, generally exhibit excellent long-term stability. When stored in sealed packaging at 30 °C/75% RH, tablets maintained potency and low impurity levels for up to five years. In contrast, liquid formulations, especially oral suspensions, degrade more rapidly once opened. For example, an opened Panadol® suspension retained acceptable quality for about five months under optimal conditions (refrigerated, protected from light) and degraded faster (around 3.5 months) under high temperatures. The main degradation product, p-aminophenol (PAP), remained below 0.005% in tablets but exceeded the 0.1% limit in most opened suspensions.Formulation factors, including pH and cosolvent use (e.g., glycerin, PEG 400), significantly affected liquid stability. Syrups with PEG 400 + glycerin maintained stable pH levels (5.6–6.8). In conclusion, solid forms are more stable than liquids, and careful formulation and adherence to storage guidelines are essential to ensure product quality.
PERBANDINGAN EFEKTIVITAS BERBAGAI METODE EKSTRAKSI KONVENSIONAL TERHADAP ISOLASI SENYAWA FENOLIK DARI BAHAN ALAM: TINJAUAN BERDASARKAN LITERATUR ILMIAH Muhammad Dhaiffullah; Adelia Ikrima; Akhmad Rizky Akbar; Anisa, Anisa; Annisa Normiani Putri; Harris Noorrahman; Muhammad Rizky; Nadia, Nadia
Journal of Innovation Research and Knowledge Vol. 5 No. 3: Agustus 2025
Publisher : Bajang Institute

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Abstract

Kajian ini memfokuskan pada Teknik ekstraksi konvensional yang umum di manfaatkan untuk mengambil senyawa fenolik dari bahan bahan alami. Senyawa fenolik, komponen bioaktif utama tumbuhan, memiliki kemampuan luar biasa untuk berfungsi sebagai antioksidan, antiinflamasi, dan antikanker. Serangkaian metode, termasuk maserasi, Maserasi bertingakat, refluks, perkolasi, digesti, infusa, dekokta, UAE dan Soxhlet, dievaluasi berdasarkan tingkat efisiensi, keuntungan operasional, dan keterbatasan teknisnya. Hasil analisis literatur menunjukkan bahwa metode konvensional dianggap memiliki kelebihan dalam hal biaya dan kemudahan penggunaan. Namun, metode ini memerlukan waktu ekstraksi yang agak lama dan berisiko menyebabkan kerusakan termal pada senyawa yang labil
Co-Authors Adelia Ikrima Akhmad Rizky Akbar Anisa Anisa Anisa Anisa Harris Noorrahman Lidya Syahjiah Muhammad Dhaiffullah Muhammad Rizky Nadia Nadia Nor Latifah Nur Luthfia Salim Siti Nurhaliza