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All Journal Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Pendidikan Kimia, Fisika dan Biologi
Siti Nor Adidah
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Dentistry Education Health Professions Nursing Public Health Veterinary

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Artikel Review : Pengaruh Perbedaan Bahan Pengikat Sintesis dan Alami dalam Sediaan Tablet Hisap Annisa Annisa; Khusnul Khotimah; Nabila Sativa; Noor Kamalliyah; Siti Nor Adidah; Nor Latifah
An-Najat Vol. 2 No. 4 (2024): NOVEMBER - An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i4.1979

Abstract

A lozenge is a form of solid pharmaceutical preparation designed to dissolve slowly in the oral cavity, providing both local and systemic effects. In lozenge formulation, binders play an important role in ensuring tablet hardness and appropriate dissolution time. This study aims to compare the effects of synthetic and natural binders on the physical properties and performance of lozenges. Synthetic binders such as PVP, CMC Na, and Hydroxypropyl Methylcellulose (HPMC) tend to provide higher tablet hardness and more controlled dissolution times. Meanwhile, natural binders such as maltodextrin, gum arabic, and jackfruit seed starch show good abilities to enhance tablet cohesion, with the additional benefits of biocompatibility and biodegradability. The research results indicate that synthetic binders provide better physical stability, while natural binders are preferred due to their environmentally friendly properties and ability to improve patient acceptance.
Perbedaan Teknik Ekstraksi dan Pengaruhnya terhadap Aktivitas Biologis serta Hasil Senyawa Fitokimia pada Bahan Alam Eprariana, Eprariana; Fiona Maulidia; Siti Nor Adidah; Chiena Nazerina Yoshi; Raida Raida; Gina Norhalija; Della Puspita
Jurnal Pendidikan Kimia, Fisika dan Biologi Vol. 1 No. 5 (2025): September : Jurnal Pendidikan Kimia, Fisika dan Biologi
Publisher : Asosiasi Riset Ilmu Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jupenkifb.v1i5.633

Abstract

This study aims to analyze the differences in various extraction techniques and their relationship to the yield and biological activity of phytochemical compounds from natural materials. The research was conducted through a systematic literature review from various reliable scientific sources over the last decade. The results indicate that extraction methods such as maceration, soxhlet extraction, microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE) have varying effectiveness. The effectiveness of these methods is highly dependent on the type of material, solvent used, and process parameters such as temperature, time, and solvent-to-material ratio. Modern extraction methods such as sonication, MAE, and UAE tend to produce higher yields and better biological activity. These modern methods have the advantage of being more time-efficient and requiring fewer solvents, thus allowing the extraction of active compounds more optimally. Additionally, technologies like microwave and ultrasonic waves help break down the cell walls of natural materials, enhancing the release of phytochemical compounds more effectively and rapidly. However, conventional methods such as maceration and soxhlet extraction remain relevant, especially for materials containing thermolabile compounds that may degrade at high temperatures. These methods are still preferred to maintain the stability of active compounds sensitive to thermal degradation. Choosing the appropriate extraction method is crucial in producing high-quality extracts that can potentially be used as raw materials for phytopharmaceuticals, supplements, or other natural products. This study provides a strong theoretical foundation for further experimental research and guidance in selecting extraction methods based on the required efficiency and effectiveness for industrial applications. Thus, this study contributes to the development of more efficient and high-quality natural products.
Perbedaan Teknik Ekstraksi dan Hubungannya dengan Uji Aktivitas dan Hasil Fitokimia Eprariana Eprariana; Fiona Maulidia; Siti Nor Adidah; Chiena Nazerina Yoshi4; Raida Raida; Gina Norhalija; Della Puspita
Jurnal Pendidikan Kimia, Fisika dan Biologi Vol. 1 No. 5 (2025): September : Jurnal Pendidikan Kimia, Fisika dan Biologi
Publisher : Asosiasi Riset Ilmu Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/jupenkifb.v1i5.631

Abstract

This study aims to analyze the differences between various extraction techniques and their relationship to the yield and biological activity of phytochemical compounds derived from natural materials. A systematic literature review was conducted by analyzing relevant and reliable scientific publications published within the last five years. The findings indicate that extraction methods such as maceration, soxhletation, microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE) demonstrate varying levels of effectiveness depending on the type of material, solvent polarity, extraction temperature, and duration of the process. Modern extraction methods, particularly sonication, MAE, and UAE, have been shown to produce higher yields with enhanced biological activity while offering greater efficiency in terms of reduced time and solvent consumption. On the other hand, conventional techniques such as maceration and soxhletation remain relevant, particularly for thermolabile compounds that are sensitive to high temperatures. The selection of an appropriate extraction method plays a crucial role in obtaining high-quality extracts that can serve as potential raw materials for phytopharmaceuticals, functional foods, dietary supplements, and other natural products. This review not only highlights the advantages and limitations of each technique but also emphasizes the importance of aligning method selection with specific research objectives and compound characteristics. Overall, this study provides a theoretical foundation for future experimental research and serves as an initial guideline for determining extraction strategies based on efficiency, effectiveness, and sustainability.
Co-Authors Annisa Annisa Chiena Nazerina Yoshi Chiena Nazerina Yoshi4 Della Puspita Eprariana Eprariana Eprariana, Eprariana Fiona Maulidia Gina Norhalija Khusnul Khotimah Nabila Sativa Noor Kamalliyah Nor Latifah Raida Raida