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Madaniyah, Luailik
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Materials Science & Nanotechnology Physics

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Stability of Biologically Synthesized Silver Nanoparticles (AgNPs) Using Acalypha indica L. Plant Extract as Bioreductor and Their Potential as Anticancer Agents Against T47D Cells Madaniyah, Luailik; Fiddaroini, Saidun; Hayati, Elok Kamilah; Rahman, Moh. Farid; Sabarudin, Akhmad
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.101-110

Abstract

This work investigates the anticancer potential of silver nanoparticles (AgNPs) against T47D cells as well as the stability of AgNPs manufactured using extract from Acalypha indica L. used as a bioreductant. The plant extract was used to produce and stabilize AgNPs, and stability was tracked for 30 days using UV-Vis spectroscopy and Particle Size Analysis (PSA), which included evaluations of extended sun exposure. Transmission Electron Microscopy (TEM) was used to characterize the size and shape of the nanoparticles, and Fourier Transform-Infrared Spectroscopy (FT-IR) was used to determine which functional groups were responsible for stabilization. Despite a gradual size increase, the AgNPs remained stable throughout the study period. The MTT assay confirmed their potent cytotoxicity against T47D cells, underscoring the potential of Acalypha indica-derived AgNPs as stable and effective agents for cancer therapy, offering a promising alternative for novel anticancer treatments.
Co-Authors Akhmad Sabarudin Elok Kamilah Hayati Fiddaroini, Saidun Moh. Farid Rahman