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All Journal JURNAL KIMIA SAINS DAN APLIKASI El-Hayah : Jurnal Biologi Science and Technology Indonesia
Fiddaroini, Saidun
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Application of Moringa Leaves (Moringa oleifera) in Liquid Organic Fertilizer for Red Spinach (Amaranthus tricolor L) Plant Growth Fiddaroini, Saidun; Yulianti, Eny
El-Hayah:Jurnal Biologi Vol 9, No 3 (2023): EL-HAYAH (VOL 9, NO 3 September 2023)
Publisher : Program Study of Biology, Science and Technology Faculty, UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v9i3.21958

Abstract

Industrial and social activities have a significant impact on environmental degradation, with soil pollution being one of the consequences. Consequently, plants are unable to achieve proper growth. One viable solution lies in the application of liquid organic fertilizer. Liquid organic fertilizer derived from naturally fermented Moringa leaves presents a potential remedy to this issue. Moringa leaf liquid organic fertilizer contains essential macronutrients (N: 4.02%; Ca: 12.3%; P: 1.17%; Mg: 0.10%; K: 1.8%; and Na: 1.16%), micronutrients (Zn, Fe, Cu), and growth hormones (zeatin and cytokinin), making it highly suitable for use as a liquid organic fertilizer. The study encompassed two variables, namely the impact of soil pH and the effect of liquid organic fertilizer derived from Moringa leaves over a span of 30 days. The findings revealed that red spinach plants failed to thrive in soil with a pH ranging from 3.5 to 4. However, when cultivated in soil with a pH of 4.5, they exhibited a lifespan of 7 days, while in soil with a pH of 5, growth could be sustained for 9 days. Red spinach demonstrated favorable growth rates at pH levels of 5.5, 6, 6.5, and 7, albeit at different rates. Notably, the height growth of red spinach plants, when watered with the addition of liquid organic fertilizer derived from Moringa leaves, proved to be 1.4 times faster compared to those without organic fertilizer. Furthermore, the length growth ratio of red spinach leaves, when treated with the aforementioned liquid organic fertilizer, exceeded that of plants without organic fertilizer by 1.375 times, highlighting the accelerated growth of Moringa leaves.
Stability of Biologically Synthesized Silver Nanoparticles (AgNPs) Using Acalypha indica L. Plant Extract as Bioreductor and Their Potential as Anticancer Agents Against T47D Cells Madaniyah, Luailik; Fiddaroini, Saidun; Hayati, Elok Kamilah; Rahman, Moh. Farid; Sabarudin, Akhmad
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.101-110

Abstract

This work investigates the anticancer potential of silver nanoparticles (AgNPs) against T47D cells as well as the stability of AgNPs manufactured using extract from Acalypha indica L. used as a bioreductant. The plant extract was used to produce and stabilize AgNPs, and stability was tracked for 30 days using UV-Vis spectroscopy and Particle Size Analysis (PSA), which included evaluations of extended sun exposure. Transmission Electron Microscopy (TEM) was used to characterize the size and shape of the nanoparticles, and Fourier Transform-Infrared Spectroscopy (FT-IR) was used to determine which functional groups were responsible for stabilization. Despite a gradual size increase, the AgNPs remained stable throughout the study period. The MTT assay confirmed their potent cytotoxicity against T47D cells, underscoring the potential of Acalypha indica-derived AgNPs as stable and effective agents for cancer therapy, offering a promising alternative for novel anticancer treatments.
Nanoparticle-Enhanced 3D-Connector Microfluidic Paper-Based Analytical Device (3D-µPADs) for Sensitive and Cost-Effective Detection of Albumin-Creatinine Ratio in Urine Sample Sabarudin, Akhmad; Fiddaroini, Saidun; Fahmi, Ahmad Luthfi; Roja’i, Abdul Munir; Salsabila, Isadora Evani; Aulanni’am; Srihardyastutie, Arie; Susanti, Hani; Samsu, Nur
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.504-518

Abstract

Chronic kidney disease (CKD) is a global health challenge affecting over 800 million people worldwide. Early detection is crucial to prevent progression to end-stage renal disease (ESRD), where life-saving interventions like dialysis or transplantation are necessary. Among the markers for early kidney damage, the Albumin Creatinine Ratio (ACR) in urine is one of the most reliable. Conventional methods of ACR detection, such as LC/MS-MS and ELISA, are highly accurate but require expensive equipment and skilled personnel, limiting their accessibility, especially in resource-limited settings. To address this, we developed a 3D-connector microfluidic paperbased analytical device (3D-µPADs) enhanced with gold nanoparticles (AuNPs) for sensitive and low-cost ACR detection. The integration of AuNPs amplifies colorimetric signals, enhancing the visual distinction in albumin detection. Our 3D-µPADs werefabricated using chromatographic paper Whatman No. 1 with hydrophobic barriers created by solid wax printing, followed by reagent immobilization for albumin and creatinine detection. The colorimetric and distance responses, based on reactions with Bromocresol Green (BCG) and Chrome Azurol S-Palladium (CAS-Pd2+), were analyzed using ImageJ software to quantify albumin and creatinine levels. The 3D-µPADs exhibited optimal sensitivity and accuracy, with linear detection ranges for albumin and creatinine of 30–400 mg/g. Validation with human urine samples demonstrated an accuracy of 93.04%, suggesting that 3D-µPADs offer a promising alternative for early nephropathy detection. Our findings provide a cost-effective, accessible tool for CKD screening, potentially transforming diagnostics in low-resource environments.
Potential Analysis of Snakehead Fish Albumin Extract (Channa striata) as Immunostimulant and Anti-Inflammatory in Indomethacin-Induced Inflammatory Bowel Disease (IBD) Rats Panjaitan, Tina Fransiskha Carolyn; Fiddaroini, Saidun; Suprayitno, Eddy; Aulanni’am, Aulanni’am; Hardoko, Hardoko
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.725-740

Abstract

Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal disorder driven by oxidative stress and immune dysregulation, often exacerbated by prolonged non-steroidal anti-inflammatory drug (NSAID) use. Conventional therapies provide symptomatic relief but are limited by severe adverse effects, necessitating safer alternatives. Channa striata (snakehead fish) is a rich source of albumin, essential amino acids, and bioactive compounds with potential immunomodulatory and anti-inflammatory effects. This study investigates the therapeutic efficacy of purified Channa striata albumin extract in an indomethacin-induced IBD rat model. Albumin was isolated via ammonium sulfate precipitation and characterized by SDS-PAGE, antioxidant activity (DPPH assay), and amino acid profiling. Rats were treated with Channa striata albumin (100-300 mg/kg BW) for 14 days post-indomethacin induction. Compared to controls and diclofenac-treated groups, the extract significantly reduced malondialdehyde (MDA) levels (up to 90.69%), improved jejunal histoarchitecture, and enhanced occludin expression. Immunohistochemistry showed a marked reduction in CD4+T cell infiltration, indicating immunomodulatory activity. These findings establish Channa striata albumin as a potent natural antioxidant and immunomodulator, offering a safer alternative to NSAIDs for IBD management.
Synthesis of NaX Zeolite from Blitar Kaolin via Hydrothermal and Sonication Methods with Alkali Fusion Pre-treatment Khalifah, Susi Nurul; Fiddaroini, Saidun; Arifah, Aminatus; Hasanah, Awwali Maf’ulah; Prasetyo, Anton
Jurnal Kimia Sains dan Aplikasi Vol 28, No 5 (2025): Volume 28 Issue 5 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.5.274-282

Abstract

NaX zeolite, widely recognized for its applications in cation exchange, adsorption, and catalysis, was successfully synthesized from Blitar natural kaolin using an alkali fusion pre-treatment, followed by two comparative synthesis methods: hydrothermal and sonication. The synthesis was conducted at 70°C for 2 and 4 hours. Optimal conditions were achieved with a NaOH/kaolin weight ratio of 2.0 and a synthesis gel composition of 10SiO2: 1Al2O3: 6Na2O: 180H2O (molar ratio). X-ray diffraction (XRD) confirmed the transformation of natural kaolin into sodium silicate, with sonication yielding phase-pure NaX zeolite, while the hydrothermal method resulted in NaX with sodalite impurities. Fourier-transform infrared (FTIR) spectroscopy identified characteristic NaX vibrations, and scanning electron microscopy (SEM) revealed cubic-shaped particles in the sonication method. The sonication process accelerated crystallization, producing higher-purity zeolite in shorter times than hydrothermal synthesis. These findings emphasize the effectiveness of sonication in enhancing the crystallinity and purity of NaX zeolite, offering a robust, time-efficient alternative for large-scale zeolite production.
Co-Authors Akhmad Sabarudin Anton Prasetyo Arie Srihardyastutie Arifah, Aminatus Aulanni’am Aulanni’am, Aulanni’am Eddy Suprayitno Elok Kamilah Hayati Eny Yulianti, Eny Fahmi, Ahmad Luthfi Hani Susanti, Hani Hardoko Hardoko Hasanah, Awwali Maf’ulah Madaniyah, Luailik Moh. Farid Rahman Nur Samsu Roja’i, Abdul Munir Salsabila, Isadora Evani Susi Nurul Khalifah Tina Fransiskha Carolyn Panjaitan, Tina Fransiskha Carolyn