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All Journal Science and Technology Indonesia Jurnal INKOFAR
Fadilah, Ade
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Uncaria gambir Based Green Synthesis of Inorganic Nanoparticles for Photothermal Induced Thrombolytic and Antibacterial Applications Fithri, Najma Annuria; Mardiyanto; Fadilah, Ade; Pratiwi, Aisyah; Alisyahbana, Sutan Satya; Alhafiz, Muhammad Faris; Maharani, Nabila Puan
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.303-312

Abstract

Application of natural compounds in the field of nanoparticle synthesis have been explored due to their robust application and safety. Additionally, these compounds exhibit activities which can be utilised for their medicinal purposes. One of the most useful compounds is catechin, a polyphenolic compound present in high concentration in Uncaria gambir. Herein, we developed inorganic nanoparticles (NPs) based on green synthesis with gambir extract (GE) to produce iron oxide (GE-IONP), gold (GE-AuNP) and silver nanoparticles (GE-AgNP). These nanoparticles were then subjected to observation towards their photothermal activity for the treatment of thrombosis and antibacterial activity. Based on our evaluation, the NPs we obtained were able to exude photothermal effect, indicated by the significant increase of temperature of the solution of around 5-15 ◦C. Evaluation of thrombolytic potential towards thrombus with an in vitro model showed reduction of thrombus mass of around 40-50%, significantly improves the thrombolytic activity compared to GE alone. Antibacterial activity of laser induced GE-AgNP, GE-AuNP and GE-IONP on Escherichia coli and Staphylococcus aureus demonstrated similar strength in inhibiting bacterial growth with broad spectrum antibiotics. Samples containing the NPs that were irradiated with laser were more efficient in preventing bacterial growth when compared to the NPs samples that were not subjected to laser, proving the synergistic mechanism of NPs and laser towards antibacterial effect. Based on the results we obtained, gambir based inorganic particles showed promising results as thrombolytic and antibacterial agent.
SISTEM OTOMASI AKUAPONIK PINTAR BERBASIS ARDUINO Putri, Salsanabila Mariestiara; Alpiani, Alpiani; Fadilah, Ade
Jurnal Inkofar Vol 9, No 1 (2025)
Publisher : Politeknik META Industri Cikarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46846/jurnalinkofar.v9i1.414

Abstract

Kementrian Kesehatan telah memperkirakan pada tahun 2035, sebesar 65% penduduk akan menghuni perkotaan, terutama di 16 kota besar di Indonesia. Meningkatnya jumlah penduduk menyebabkan kebutuhan pangan terus meningkat. Pada kondisi demikian, akuaponik menjadi salah satu jawaban untuk menekan angka permintaan pangan untuk penduduk kota. Melalui sistem akuaponik, akan menghasilkan dua komoditas sekaligus yaitu sayuran dan ikan. Namun, sistem akuaponik konvensional membutuhkan tenaga dan cukup menyita waktu karena harus selalu hadir ditempat untuk melakukan proses perawatan. Oleh sebab itu, dibutuhkan sistem otomasi cerdas dari segi monitoring maupun controlling berbasis Arduino. Metode penelitian yang dipakai adalah Research and Development program arduino. Variabel pada sistem otomasi akuaponik pintar berbasis Arduino ini adalah variabel monitoring dan controlling. Sistem monitoring terletak pada pemantauan kelembaban media tanam, suhu, TDS air, dan pH air yang ditampilkan dalam LCD, serta sistem controlling dengan pengontrolan yang terletak pada mengatur kadar kelembaban media tanam dengan pompa dan lampu. Hasil pengukuran pada sistem monitoring ini adalah 0.49% untuk nilai error pada sensor suhu, 0.95% untuk nilai error sensor kelembaban, 0.12% untuk nilai error pada sensor TDS, 1.64 % untuk nilai error sensor pH. Hasil pada sistem controlling ini adalah pompa dan lampu dapat berjalan secara otomatis dengan sistem kendali fuzzy.
Co-Authors Aisyah Pratiwi, Aisyah Alhafiz, Muhammad Faris Alisyahbana, Sutan Satya Alpiani, Alpiani Maharani, Nabila Puan Mardiyanto Najma Annuria Fithri, Najma Annuria Putri, Salsanabila Mariestiara