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All Journal Science and Technology Indonesia Communications in Science and Technology Jurnal Teknologi dan Komputer Abdi Jurnal Publikasi Jurnal Stasiun Geofisika Sleman (JSGS) Jurnal Sains Materi Indonesia
Mardiyanto
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Earth & Planetary Sciences Engineering Environmental Science Industrial & Manufacturing Engineering Materials Science & Nanotechnology Physics Social Sciences Other

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Mikrozonasi Indeks Kerentanan Seismik Menggunakan Metode HVSR di Kapanewon Galur, Kabupaten Kulon Progo Kalyana Mita, Ailing; Sunardi, Bambang; Mardiyanto
Jurnal Stasiun Geofisika Sleman Vol. 1 No. 2 (2023): Jurnal Stasiun Geofisika Sleman (JSGS)
Publisher : Stasiun Geofisika Kelas I Sleman

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Abstract

Kapanewon Galur in Kulon Progo is close to the Progo Fault, a fault with signs of activity about 35 km long. This area is included in a seismically active area because it is close to plate subduction activity, making it prone to earthquakes. This condition makes Kapanewon Galur an area that has the potential to experience earthquakes. The longer existence of the Progo Fault compared to the Opak Fault indicates a greater risk, allowing larger and more destructive earthquakes to occur in the future, compared to the 2006 earthquake in Bantul. Obtaining the dominant frequency (f0) and amplification factor (A0) values using the HVSR method helps to see the seismic vulnerability index (Kg) in the area. The microzonation of the area is also an important criterion for identifying earthquake-prone areas in the Kapanewon Galur area. Findings from research in Kapanewon Galur using the HVSR method show that the f0 ranges from 0.15 to 1.57 Hz, A0 value ranges from 1.24 to 3.61, and Kg ranges from 4.8 to 87.85. By considering these values, it can be concluded that Kapanewon Galur can be classified as an area with a high seismic vulnerability index.
Pemanfaatan Fatiando a Terra untuk Analisis Data Gravitasi GGMplus berbasis Pustaka Python Amelia, Tri; Sunardi, Bambang; Mardiyanto; Prayoedhie, Setyoajie
Jurnal Stasiun Geofisika Sleman Vol. 1 No. 2 (2023): Jurnal Stasiun Geofisika Sleman (JSGS)
Publisher : Stasiun Geofisika Kelas I Sleman

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Abstract

The gravity method is one of the methods that can be used for regional geological studies according to differences in rock density due to variations in the Earth's gravitational field. Gravity data is not limited to field data but can also use satellite data such as GGMplus. The interpretation of gravity data in this paper is based on the results of regional anomalies and residual anomalies in the research area. Initially, the data was processed using the python verde, harmonica, boule, and pooch libraries by Fatiando a terra. The results of processing GGMplus gravity data using the python library by Fatiando a Terra indicate regional anomaly values ranging from 60 mGal to 130 mGal whereas the residual anomaly is between -30 mGal to 30 mGal. Synchronization between the position of positive and negative values of the residual anomaly and the fault coordinates coincide so that the faults in the Special Region of Yogyakarta are identified.
Combination Effect of Extracts and Pure Compounds of Endophytic Fungi Isolated from Sungkai (Peronema canescens) Leaves on Antioxidant Activity Elfita; Oktiansyah, Rian; Mardiyanto; Setiawan, Arum; Widjajanti, Hary
Science and Technology Indonesia Vol. 9 No. 1 (2024): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.1.69-76

Abstract

Endophytic fungi extracts have various biological and pharmacological activities as natural antioxidants which have the potential to be developed in the pharmaceutical. Drugs made from natural substances frequently work best when they are present in large quantities. This may result in unfavorable side effects from using more of one substance at a time. This limitation can be overcome by using a combination of the extracts/pure compounds that allow synergistic interactions with strong antioxidant properties at fairly low concentrations. The purpose of this research was to determine the combined effect of endophytic fungi extracts and its pure compounds on their antioxidant activity. This research was initiated by rejuvenating eight selected endophytic fungal isolates from Sungkai leaves and morphological characterization was carried out. Each fungus was cultivated in PDB medium for 4 weeks under statistical conditions. Ethyl acetate was used to extract the endophytic fungi’s liquid culture, which was then evaporated. Each endophytic fungal extract (PD1-PD8) and their five pure compounds were tested for antioxidant activity by the DPPH method. Then a combination of two and three extracts was carried out with a ratio of 1:1. The results show that the interaction of the mixture of endophytic fungi extracts and their pure compounds can be classified as synergistic (combined effect of the extracts > individual effects), additive (combined effect of the extracts = individual effect), and nothing is antagonistic (combined effect of the extracts < individual effects). The best combination in this study was PD4+PD5+PD6 (1:1:1) which could be used as a formula for further research into in vivo immunostimulant tests. Another conclusion from this research is that the pure compounds contained in the extracts have lower antioxidant activity than the extracts and do not have a synergistic effect on the combination.
Formulation and Evaluation of Gambier (Uncaria gambir)-Chitosan Microparticle Intranasal Delivery for Alzheimer’s Diseases Fithri, Najma Annuria; Mardiyanto; Fitrya; Rahmah, Asfaraeni; Annisa, Novilia Megi
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.284-298

Abstract

Alzheimer’s Disease (AD), the most common form of dementia continues to be the deadliest neuro degenerative disease in recent years. Despite significant efforts to mitigate the progression of the disease, there is no known cure and development towards a more effective treatment is still lacking. AD is marked by exceptionally low amount of acetylcholine in the brain, formation of tau protein, and amyloid beta plaque. Current drugs of choice for treating AD, namely donepezil and memantine, are acetylcholinesterase (AChE) inhibitors which focused on delaying the onset of cognitive decline by maintaining acetylcholine concentration. Gambier water extract (GWE) contains high level of polyphenols which act as an antioxidant, exhibit strong correlation with AChE inhibitor. The aim of this research is to formulate and encapsulate GWE inside a microparticle system composed of chitosan and different crosslinkers, STPP (IMGS) and CaCl2 (IMGC), which were then characterized as AChE inhibitor using Ellman’s method. Variations of the formula were designed following Box-Behnken experimental design with chitosan and crosslinker concentration, crosslinker type, and stirring speed as variables. Initial activity of GWE, IMGS and IMGC as antioxidant were confirmed with DPPH method, obtaining a strong activity of 88.01, 82.11, and 84.99% DPPH inhibition at 100 ppm respectively. Promisingly, at concentration of 100 ppm GWE demonstrated AChE inhibition of 30.36%. However, this activity reduced after encapsulation into IMGS and IMGC, with 14.63% and 18.65% AChE inhibition, which can be linked to the relatively sustained diffusion of GWE from the polymer matrix. IMGS and IMGC diffusion profile showed release of 23.24% and 21.89% after 6 hours, with significant increase in diffusion after 24 hours with 74.92% and 71.19% respectively. Despite showing sustained release behaviour, both IMGS and IMGC ex-vivo diffusion significantly improved when compared to GWE which only diffused 51.84% after 24 hours. This result indicates encapsulation of GWE into a polymeric carrier could increase gambier diffusion through the nasal mucous membrane, significantly improving the potential to penetrate into the brain systemic circulation. Combined with desirable intranasal delivery characteristics, this research was able to demonstrate the promising potential of gambier water extract polymeric system as AChE inhibitors for AD therapy.
Optimization of Nanoemulsion Formula Containing Erythromycin with VCO and Varying Concentrations of Tween-80 and PEG-400 Mardiyanto; Mohadi, Risfidian; Fithri, Najma Annuria; Kurniawan, Gilang
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.697-709

Abstract

Erythromycin, a macrolide antibiotic is classified into Biopharmaceutical Classification System (BCS) class II which has low solubility in water. The low solubility corresponds to the bioavailability in the blood. One strategy to increase the solubility of Erythromycin is the formulation of erythromycin in nanoemulsion. This research aims to form nanoemulsion using the PIT (Phase Transition Temperature) method for obtaining the optimum formula of erythromycin nanoemulsion using virgin coconut oil (VCO) can be found with varying concentrations of Tween 80 surfactant and PEG 400 cosurfactant. The selection of the optimum formula was assisted by Design Expert software with the Factorial design method 22. The basis for determining the optimum formula is based on the results of organoleptic characterization tests, adsorption efficiency (%EE), percent transmittance, viscosity test, pH test, and stability test. The optimum formula was nanoemulsion which had a concentration of Tween 80 25% and PEG 400 25% as a desirability value of <1. The results of the optimum formula showed that the particle size was 170.6±12.8594 nm, polydispersity index (PDI) 0.403±0.04406, and zeta potential -8.8667±0.25697 mV and had an appropriate stability without phase separation during stability test.
Mg/Cr-(COO)22- layered double hydroxide for malachite green removal Palapa, Neza Rahayu; Badri, Arini Fousty; Mardiyanto; Mohadi, Risfidian; Taher, Tarmizi; Lesbani, Aldes
Communications in Science and Technology Vol 7 No 1 (2022)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.7.1.2022.851

Abstract

Mg/Cr layered double hydroxide (LDH) was prepared and modified using an intercalation of oxalate anions ((COO)22-) to form Mg/Cr-(COO)22. The materials were then investigated to malachite green removal to determine the adsorption ability. Furthermore, the desorption process and regeneration of adsorbent were systematically conducted. The adsorption of green malachite on Mg/Cr- LDH and Mg/Cr-(COO)22- materials fitted to the pseudo-second-order (PSO) kinetic model and Freundlich isotherm model with an adsorption capacity of 33.784 mg/g (333K) for Mg/Cr LDH and 64.516 mg/g (333K) for Mg/Cr-(COO)22-. Thermodynamic data showed that the adsorption process was spontaneous and endothermic. Also, the appropriate reagent desorption study was found as hydrochloric acid and material regeneration studies exhibited a good recycling performance after 3 times cycles and, the Mg/Cr-oxalate showed a good performance for malachite green adsorption. It can be concluded that Mg/Cr--(COO)22- can adsorb the dye stuffs effectively.
Uncaria gambir Based Green Synthesis of Inorganic Nanoparticles for Photothermal Induced Thrombolytic and Antibacterial Applications Fithri, Najma Annuria; Mardiyanto; Fadilah, Ade; Pratiwi, Aisyah; Alisyahbana, Sutan Satya; Alhafiz, Muhammad Faris; Maharani, Nabila Puan
Science and Technology Indonesia Vol. 10 No. 1 (2025): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.1.303-312

Abstract

Application of natural compounds in the field of nanoparticle synthesis have been explored due to their robust application and safety. Additionally, these compounds exhibit activities which can be utilised for their medicinal purposes. One of the most useful compounds is catechin, a polyphenolic compound present in high concentration in Uncaria gambir. Herein, we developed inorganic nanoparticles (NPs) based on green synthesis with gambir extract (GE) to produce iron oxide (GE-IONP), gold (GE-AuNP) and silver nanoparticles (GE-AgNP). These nanoparticles were then subjected to observation towards their photothermal activity for the treatment of thrombosis and antibacterial activity. Based on our evaluation, the NPs we obtained were able to exude photothermal effect, indicated by the significant increase of temperature of the solution of around 5-15 ◦C. Evaluation of thrombolytic potential towards thrombus with an in vitro model showed reduction of thrombus mass of around 40-50%, significantly improves the thrombolytic activity compared to GE alone. Antibacterial activity of laser induced GE-AgNP, GE-AuNP and GE-IONP on Escherichia coli and Staphylococcus aureus demonstrated similar strength in inhibiting bacterial growth with broad spectrum antibiotics. Samples containing the NPs that were irradiated with laser were more efficient in preventing bacterial growth when compared to the NPs samples that were not subjected to laser, proving the synergistic mechanism of NPs and laser towards antibacterial effect. Based on the results we obtained, gambir based inorganic particles showed promising results as thrombolytic and antibacterial agent.
Investigation of Physical Properties, Solubility, Dissolution Profiles, and Flow Properties of Solid Dispersion Loading Cefixime Using Chitosan and Sodium Alginate Mardiyanto; Fithri, Najma Annuria; Shiyan, Shaum; Satrio, Fakhri D.
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.943-951

Abstract

The co-grinding method has been used to produce solid dispersions that increase the solubility of drug substances by utilizing hydrophilic polymers. The purpose of this study was to evaluate the effect of chitosan and variations of sodium alginate as polymers on the dissolution rate of cefixime solid dispersion using the co-grinding technique. The cefixime solid dispersion formulation was made in three variations of sodium alginate formulas, namely 200 mg, 250 mg, and 300 mg. Sample characterization was carried out using XRD, FTIR, SEM, solubility testing, dissolution rate, and flow properties. The results showed that Formula 2 (F2) cefixime solid dispersion was the best formula because the degree of crystallinity decreased to 21.71%, and FTIR analysis showed the functional group interaction. Evaluation of cefixime solid dispersion showed changes in particle morphology. In addition, there was an increase in the transmittance percentage in SIF of 98.587 ± 0.019 and an increase in the dissolution rate of cefixime of 83.61%, an increase in the flow rate of 6.3 ± 0.14 grams/second, an angle of repose of 26.4 ± 0.4◦, a compressibility index of 16.3 ± 0.29%, and a Hausner ratio of 1.19 ± 0.35.
SOSIALISASI PROFESI DI INDUSTRI TEKNOLOGI INFORMASI DALAM MENGANTISIPASI TANTANGAN PELUANG DI ERA DIGITAL Sudarno Wiharjo; Mardiyanto; Nilovar Asyiah
Abdi Jurnal Publikasi Vol. 3 No. 6 (2025): Juni
Publisher : Abdi Jurnal Publikasi

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Abstract

In the digital era, information technology has become a key pillar across various aspects of life, including the world of work. Rapid developments in artificial intelligence, big data, cloud computing, and the Internet of Things (IoT) have driven significant changes in labor demands. However, a lack of understanding about careers in the technology industry and the gap between education and industry needs remain major challenges. Career awareness programs in the field of technology are essential to help individuals understand the diverse career opportunities, required skills, and existing challenges. The technology sector offers a wide range of professions such as software engineer, data scientist, cybersecurity analyst, and cloud engineer—each requiring specialized expertise. While the demand for technology professionals continues to rise, intense competition and rapid technological advancements demand continuous learning and adaptability. Key challenges in this industry include high work pressure, cybersecurity regulations, and maintaining a work-life balance. Therefore, beyond technical skills, time management, communication, and problem-solving abilities are also crucial. Collaboration among educational institutions, government, and industry is necessary to provide relevant insights and training that prepare the workforce for future demands. This community service program aims to enhance public understanding of technology-related professions, equip participants with essential digital skills, and assist them in designing effective career strategies. Through this approach, more individuals are expected to seize opportunities in the tech industry and contribute to innovations that benefit society.
Perancangan Alat Sistem Keamanan Untuk Museum Balla Lompoa Berbasis Raspberry PI Mardiyanto; Baco, Syarifuddin; Martani, Ahmad
Jurnal Teknologi dan Komputer (JTEK) Vol. 4 No. 02 (2024): DESEMBER
Publisher : Teknik Informatika Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56923/jtek.v4i02.226

Abstract

Museum Balla Lompoa Bantaeng adalah situs budaya dengan nilai historis tinggi yang menyimpan berbagai artefak berharga. Namun, museum ini rentan terhadap ancaman seperti pencurian dan kerusakan artefak. Untuk mengatasi masalah ini, diperlukan sistem keamanan yang efektif dan andal. Penelitian ini bertujuan untuk merancang sistem keamanan berbasis Raspberry Pi yang dapat diterapkan di Museum Balla Lompoa Bantaeng. Sistem ini dilengkapi dengan sensor cahaya, sensor gerak, dan alarm yang terintegrasi dalam platform berbasis Internet of Things (IoT) sensor cahaya berfungsi sebagai penerima cahaya sebagai input ke rasberry Pi. sensor gerak berfungsi sebagai pendeteksi gerak yang memberi inputan ke rasberry Pi dan mengeluarkan output ke buzzer. Metode penelitian yang digunakan adalah Research and Development (R&D), yang mencakup tahap analisis kebutuhan, desain sistem, implementasi, uji coba, dan evaluasi. Pada tahap analisis kebutuhan, dilakukan identifikasi terhadap kebutuhan sistem keamanan museum balla lompoa. Desain sistem mencakup perancangan perangkat keras dan perangkat lunak. Implementasi melibatkan perakitan sensor dan pemrograman Raspberry Pi untuk mengontrol sistem keamanan. Uji coba memastikan sistem berfungsi sesuai rencana, sementara evaluasi menilai efektivitasnya. Hasil penelitian menunjukkan bahwa sistem keamanan berbasis Raspberry Pi ini dapat memberikan perlindungan optimal terhadap artefak Museum Balla lompoa, mendeteksi pergerakan pintu museum, dan mengirimkan notifikasi. Implementasi sistem ini diharapkan dapat meningkatkan keamanan pintu museum dan melindungi warisan budayanya.
Co-Authors A. K. Riva A. Mahyudin A. Taufiq Aisyah Pratiwi, Aisyah Aldes Lesbani Alhafiz, Muhammad Faris Alisyahbana, Sutan Satya Amelia, Tri Annisa, Novilia Megi Arum Setiawan Baco, Syarifudddin Badri, Arini Fousty Bambang Sunardi, Bambang E. Sukirman Elfita Fadilah, Ade Fitrya . Hary Widjajanti Kalyana Mita, Ailing Kurniawan, Gilang Maharani, Nabila Puan Martani, Ahmad N. Shabrina Najma Annuria Fithri, Najma Annuria Nilovar Asyiah Oktiansyah, Rian Prayoedhie, Setyoajie Rahmah, Asfaraeni Risfidian Mohadi S. Ahda Satrio, Fakhri D. Shaum Shiyan Sudarno Wiharjo Syarifuddin Baco Tarmizi Taher