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All Journal Indonesian Journal of Obstetrics & Gynecology Science Global Health Management Journal Jurnal Impresi Indonesia
Sedayu, Sedayu
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Journal : global health management journal

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Correlation between Duration of Antiretroviral Therapy and Glomerular Filtration Rate in People Living with HIV/AIDS: A Cross-sectional Study in Cirebon, West Java, Indonesia Ayudhipasha, Tiara Sekar; Herdwiyanti, Menik; Sedayu, Sedayu
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1182

Abstract

Background: West Java ranks the highest Province with Human Immunodeficiency Virus (HIV) case in 2023. An estimated 1.648 patients estimated receive antiretroviral therapy (ART). Kidney disease contributes mortality amongst people living with HIV/AIDS (PLWH). Tenofovir disoproxil fumarate (TDF)-based ART was associated as risk factor of kidney disorders, indicate by declining glomerular filtration rate (GFR). However, there is limited study whether kidney disease among PLWH were related to ART use in Indonesia. Aims: To determine correlation between duration of antiretroviral therapy and glomerular filtration rate (GFR) in people living with HIV/AIDS. Methods: This is an observational study with cross-sectional design. Eighty-nine HIV patients on antiretroviral therapy for at least three months with normal baseline GFR were studied. Estimated GFR calculated using the Cockcroft-Gault equation. Data obtained were analyzed with spearman correlation test. Results: Among 89 subjects, as many as 38 patients (42.7%) on therapy less than 12 months, 29 patients (32.6%) were on ART more than 24 months, and 22 patients (24.7%) 12-24 months. ART with normal kidney function were 62 patients (69.7%). Whereas 29.2% were mildly decrease GFR, and only 1.1% were mild to moderate decrease GFR. The analytical statistic showed a no significant between duration of antiretroviral therapy and GFR in PLWH with a p-value of 0.199 and Spearman’s r of 0.137. Conclusion: There was no significant correlation between duration of antiretroviral therapy and glomerular filtration rate in PLWH.
Demographics and Histopathological Characteristics of Lung Cancer Patients in Cirebon District, Indonesia (2021-2023) Sulaeman, Syakira Puteri; Fitrie, Alya Amila; Sedayu, Sedayu
GHMJ (Global Health Management Journal) Vol. 7 No. 3s (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-741070

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Background: Based on the Global Burden of Cancer Study (GLOBOCAN) in 2020, In the world, lung cancer is the first cause of death. In Indonesia, lung cancer is the third highest.  Lung cancer is classified into two cell types: Small Cell Lung Cancer and Non-Small Cell Lung Cancer. There are two types of Non-Small Cell Lung Cancer: squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Aims: To determine the demographics and histopathological characteristics of lung cancer patients in Cirebon District (2021-2023). Methods: This research employed a descriptive observational method. The data were collected from general hospitals’ medical records of lung cancer patients at RSUD Waled Cirebon and RSUD Arjawinangun in 2021-2023 using the total sampling technique. There were 69 respondents met the inclusion criteria for this recent study. Results: In this study, there were 68.1% of patients aged from 46 to 70 years, and the majority were male (66.7%). The most common cancer cell type was adenocarcinoma (69.6%). Most patients did not have information regarding occupational data (68.1%), smoking history (98.6%), family history (98.6%), and staging (89.9%) included in their medical records. Conclusion: The analysis showed that most lung cancer patients are aged 46-70 years and male incidences in lung cancer patients were higher. The most common type of histopathological is adenocarcinoma. Related to occupational data, smoking history, family history, and staging could not be concluded because they were not included in the medical record. Received: 25 September 2024  |  Reviewed: 19 October 2024  |  Revised: 30 November 2024  |  Accepted: 12 December 2024.
Characteristics and Endoscopy Findings of Liver Cirrhosis Patients at Waled Hospital, Cirebon, Indonesia (2020-2023) Azahra, Afifah Humaira; Sedayu, Sedayu; Zein, Ahmad Fariz Malvi Zamzam
GHMJ (Global Health Management Journal) Vol. 7 No. 3s (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-741071

Abstract

Background: Hepatic cirrhosis is a terminal manifestation of chronic liver disease. The causes of cirrhosis in the Asia Pacific it was caused by hepatitis B. Older adults are more likely to experience complications, which might be due to abnormalities in the liver. Various complications occurred during the progression from compensated to decompensated, and endoscopic examination showed images of gastroesophageal varices or PHG. Aims: The aim was to determine the characteristics of liver cirrhosis patients and the endoscopy findings at waled hospital from 2020 to 2023. Methods: This research used descriptive observational methods. The sample in this study were patients with liver cirrhosis at Waled hospital from 2020-2023, there were 135 sample who were selected using total sampling techniques. Information was acquired from medical records of 33 patients who met the consideration rules. Results: This study showed that the largest number of patients with liver cirrhosis based on age 45 years old (12.1%), predominantly male (72.7%), with the etiology hepatitis B (69.7%), and all (100%) were in decompensated stage. Endoscopy results revealed that the majority of patients experiences esophageal varices and PHG (54.5%), with grade 3 esophageal varices (81.8%) and mild grade PHG (60.6%) dominating. Conclusion: The majority of patients with liver cirrhosis were 45 years old, predominantly male, with the most common etiology hepatitis B, and all were in the decompensated stage. The most common endoscopy results showed esophageal varices and PHG, with grade 3 esophageal varices and mild grade PHG. Received: 26 September 2024  |  Reviewed: 23 October 2024  |  Revised: 30 November 2024  |  Accepted: 12 December 2024.
Co-Authors Ahmad Fariz Malvi Z Zein Ayudhipasha, Tiara Sekar Azahra, Afifah Humaira Fachrezi, Mahesa Tansyia Fitrie, Alya Amila Herdwiyanti, Menik Nurbaniwati, Nunung Roswita, Kania Widya Siti Maria Ulfah, Siti Maria Sulaeman, Syakira Puteri