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Comparing Chest Radiograph Lesion Areas in Pulmonary Tuberculosis Patients with and without Diabetes Mellitus: A 2023 Study at Waled Hospital, Cirebon, Indonesia Fatihah, Hapsari Bunga; Latief, Muhammad Amar; Herdwiyanti, Menik
GHMJ (Global Health Management Journal) Vol. 8 No. 2 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-821161

Background: The Global Tuberculosis Report emphasizes a significant number of TB cases, and Indonesia is the second country in Southeast Asia with the most TB cases. Prevalence of TB increases along with the increase of Diabetes Mellitus (DM) prevalence, which both are known to have a negative impact on each other. Clinical symptoms in TB with DM differ from those in TB without DM. However, whether there is any difference in radiology examinations is unknown. This can be a consideration for determining patient therapy based on differences in the chest radiographs. Aims: To determine the Lesion Area Difference on Chest Radiographs of Pulmonary Tuberculosis Patients with and without Diabetes Mellitus at Waled Hospital in 2023. Methods: There were 96 data points based on the first taken chest radiograph from both inpatient and outpatient data, which were obtained from medical records in 2023 at Waled Hospital, Cirebon. Statistical analysis was performed using the Chi-Squared comparative test in this observational study with a cross-sectional design. Results: There were 69 tuberculosis (TB) patients without diabetes mellitus (DM) and 27 TB patients with DM. Overall, patients had minimal lesions (14.6%), moderate lesions (26.0%), and far-advanced lesions (59.4%). The Chi-Square analysis from these samples showed a p-value of 0.870. Conclusion: There is no difference in lesion area on chest x-rays in pulmonary tuberculosis patients with or without diabetes mellitus. Further research is expected to include the type of TB and history of treatment for either TB or DM.

Correlation between Duration of Antiretroviral Therapy and Glomerular Filtration Rate in People Living with HIV/AIDS: A Cross-sectional Study in Cirebon, West Java, Indonesia Ayudhipasha, Tiara Sekar; Herdwiyanti, Menik; Sedayu, Sedayu
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1182

Background: West Java ranks the highest Province with Human Immunodeficiency Virus (HIV) case in 2023. An estimated 1.648 patients estimated receive antiretroviral therapy (ART). Kidney disease contributes mortality amongst people living with HIV/AIDS (PLWH). Tenofovir disoproxil fumarate (TDF)-based ART was associated as risk factor of kidney disorders, indicate by declining glomerular filtration rate (GFR). However, there is limited study whether kidney disease among PLWH were related to ART use in Indonesia. Aims: To determine correlation between duration of antiretroviral therapy and glomerular filtration rate (GFR) in people living with HIV/AIDS. Methods: This is an observational study with cross-sectional design. Eighty-nine HIV patients on antiretroviral therapy for at least three months with normal baseline GFR were studied. Estimated GFR calculated using the Cockcroft-Gault equation. Data obtained were analyzed with spearman correlation test. Results: Among 89 subjects, as many as 38 patients (42.7%) on therapy less than 12 months, 29 patients (32.6%) were on ART more than 24 months, and 22 patients (24.7%) 12-24 months. ART with normal kidney function were 62 patients (69.7%). Whereas 29.2% were mildly decrease GFR, and only 1.1% were mild to moderate decrease GFR. The analytical statistic showed a no significant between duration of antiretroviral therapy and GFR in PLWH with a p-value of 0.199 and Spearman’s r of 0.137. Conclusion: There was no significant correlation between duration of antiretroviral therapy and glomerular filtration rate in PLWH.

PROFIL LIPID PADA PENDERITA DIABETES MELLITUS TIPE 2 DI RSUD ARJAWINANGUN PERIODE 2022 Pamungkas, Nanda Dwi; Herdwiyanti, Menik; Indriyati, Rose; Wirandoko, Ignatius Hapsoro; Astuti, Widi; Canceryta, Sherly; Romdhoni, Mohamad
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 11 No 2 (2025): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v11i2.10951

ABSTRAK LATAR BELAKANG Diabetes mellitus (DM) merupakan penyakit metabolik dengan karakteristikhiperglikemia yang terjadi karena kelainan sekresi insulin, resistensi insulin atau keduanya. Resistensi Insulindapat disebabkan oleh dislipidemia sehingga menyebabkan DM. Riset Kesehatan Dasar (2018) menunjukanadanya peningkatan yang cukup signifikan pada prevalensi diabetes mellitus dari 6,9% menjadi 8,5%. Dikabupaten Cirebon, kecamatan Arjawingun memiliki penderita DM sebanyak 699 orang di dua pelayanankesehatan data dinkes kabupaten Cirebon. TUJUAN Mengetahui gambaran karakteristik Profil Lipid PadaPenderita Diabetes Mellitus Tipe 2 di RSUD Arjawinangun. METODE Penelitian ini menggunakan metodedeskriptif observasional dengan teknik pengambilan data total sampling. Didapatkan 88 sampel dari data RekamMedik Bulan Januari sampai Desember tahun 2022 sudah memenuhi kriteria inklusi dan eklusi. Data diolahdengan analisis univariat. HASIL Hasil penelitian menunjukan penderita DMT2 di RSUD Arjawinangunmemiliki mayoritas berusia lansia akhir sebanyak 36 sampel (40,9%), lebih banyak Perempuan 64 sampel(72,7%), memiliki mayoritas BMI dengan kategori obesitas tipe 1 sebanyak 38 sampel (43,2%), kadar GDS≥300 sebanyak 71 sampel (80,7%), kadar HbA1c (>8%) 86 sampel (97,7%), kadar LDL (≥190 mg/dl) 23sampel (26,1%), kadar HDL (<40 mg/dl) 63 sampel (71,6%), Trigliserida (200-499 mg/dl) 55 sampel (62,5%),kadar Kolesterol total (≥240 mg/dl) 45 sampel (51,1%). SIMPULAN Penderita DMT2 di RSUD Arjawinangun,lebih banyak Perempuan, penderita mayoritas lansia akhir dan memiliki BMI dengan kategori obesitas. KadarGDS tidak terkontrol, kadar HbA1c mayoritas kendali buruk. Pada pemeriksaan profil lipid didapatkanmayoritas HDL kategori rendah, LDL sangat tinggi, Trigliserida tinggi, dan Kolesterol total tinggi.Kata Kunci : Profil lipid, Diabetes mellitus tipe 2, Dislipidemia, resistensi insulin. ABSTRACT BACKGROUND Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia that occursdue to abnormalities in insulin secretion, insulin resistance or both. Insulin resistance can be caused bydyslipidemia, leading to T2DM. Basic Health Research (2018) showed a significant increase in the prevalenceof diabetes mellitus from 6.9% to 8.5%. In Cirebon Regency, Arjawingun sub-district has 699 people with DM intwo health services. OBJECTIVE Determine characteristic of Lipid Profile in Patients with Type 2 DiabetesMellitus at Arjawingun hospital. METHODS This study used descriptive observational method with totalsampling data collection technique. From 239 samples 88 samples from medical record data from January toDecember 2022 with the inclusion and exclusion criteria. Data were processed with univariate analysis.RESULTS The results showed that patients with T2DM at Arjawinangun Hospital had a majority of late elderlyas many as 36 people (40.9%), more women 64 people (72.7%), had a majority of BMI with type 1 obesitycategory as many as 38 samples (43.2%), GDS levels ≥300 as many as 71 people (80.7%), HbA1c levels (>8%)86 people (97.7%), LDL levels (≥190 mg/dl) 23 people (26.1%), HDL levels (<40 mg/dl) 63 people (71.6%),Triglycerides (200-499 mg/dl) 55 people (62.5%), Total cholesterol levels (≥240 mg/dl) 45 people (51.1%).CONCLUSION Patients with T2DM at Arjawinangun Hospital, more women (72.7%) than men (27.3%), themajority of patients are elderly and have BMI in the obesity category. GDS levels are not controlled (≥300) asmuch as 80.7%, the majority of HbA1c levels are poorly controlled. In the lipid profile examination, the majorityof HDL was found to be low, LDL was very high, Triglycerides were high, and Total cholesterol was high.Keyword : Lipid profile, Diabetes mellitus, Dyslipidemia, insulin resistance.

Glycated Hemoglobin Level and Body Mass Index Correlation with Peripheral Artery Disease in Patients with Type 2 Diabetes Mellitus at Waled Hospital, Cirebon, Indonesia Auliya, Tania; Amaliyah, Nihayatul; Herdwiyanti, Menik
GHMJ (Global Health Management Journal) Vol. 7 No. 3s (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-741106

Background: Peripheral Artery Disease (PAD) is a condition that reduces blood flow to the lower extremities and is primarily caused by atherosclerosis. PAD is one of the complications of Diabetes Mellitus (DM). Diabetics have an 11.6 times more likely to develop PAD than those without diabetes. Glycated haemoglobin (HbA1c) levels >7% are at a higher risk of chronic complications. Obesity and overweight also raise the risk of developing PAD disease. However, research on the correlation between Body Mass Index (BMI) and PAD remains unclear and controversial. Aims: To analyze the correlation between HbA1c levels and BMI with the incidence of Peripheral Artery Disease in patients with type 2 Diabetes Mellitus at Waled Hospital. Methods: This is an analytical observational study with a cross-sectional design. Data was collected on patients diagnosed with type 2 Diabetes Mellitus at the Internal Medicine Clinic at Waled Hospital in June - July 2024. A total sample of 77 was obtained using consecutive sampling. The inclusion criteria were type 2 DM, aged 19-60 years, and medical record data equipped with the HbA1c levels for at least the last 3 months prior to data collection. The exclusion criteria were patients with a history of diabetic ulcers, amputation and limb disability, Acute Coronary Syndrome, stroke, kidney failure, recurrent anaemia, and blood transfusions in the last 3 months. Primary data was gathered through an ABI examination, while secondary data was obtained from medical records. The data was analysed using the Spearman correlation test. Results: Patients had poor HbA1c control (51.9%), moderate HbA1c control (29.9%) and good HbA1c control (18.2%), with the majority of patients had normal BMI (39%) followed by obese I (22.1%), overweight and obese II (16.9%). Our study showed that the distribution of PAD levels was severe (0%), moderate (3.9%), mild (44.2%), normal (46.8%), and arteriosclerotic (5.2%). The correlation test showed p-0.789 (p> 0.05) for HbA1c levels with PAD and p- 0.653 (p>0.05) for BMI with PAD. Conclusion: There was no association between glycated hemoglobin or Body Mass Index values and the incidence of PAD in patients with type 2 Diabetes Mellitus at Waled Hospital, Cirebon, Indonesia. Received: 25 September 2024 | Reviewed: 21 October 2024 | Revised: 30 November 2024 | Accepted: 11 December 2024.

Hubungan antara Hasil Skor Salzburg dan Kadar C-Reactive Protein untuk Mendeteksi Penyakit Paru Obstruktif Kronis di Rumah Sakit Umum Daerah Waled Anjani, Faizah; Silvia, Indriani; Agustina, Dwi Rosa Eka; Octavrisa, Friska; Herdwiyanti, Menik
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 10 No 3 (2024): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Fakultas Kedokteran UGJ Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33603/tumed.v10i3.9615

Latar Belakang: Penyakit Paru Obstruktif Kronis (PPOK) masih menjadi suatu penyakit ancaman bagi masyarakat di Indonesia maupun dunia. Penting bagi tenaga kesehatan untuk melakukan skrining PPOK menggunakan kuesioner. Kuesioner skrining Salzburg merupakan kuesioner skrining yang sederhana dan mudah diterapkan untuk pemilihan awal rujukan spirometri. CRP merupakan marker inflamasi yang akan meningkat pada penyakit kronis salah satunya pada PPOK. Tujuan: Mengetahui hubungan antara skor kuesioner Salzburg untuk mendeteksi PPOK dengan kadar CRP di RSUD Waled. Metode: Penelitian berupa penelitian observasional analitik, menggunakan desain penelitian cross sectional. Teknik pemilihan sample menggunakan total sampling, didapat 23 pasien. Hasil: Hasil deteksi PPOK menggunakan kuesioner skrining Salzburg di RSUD Waled, dari 23 responden, sebanyak 18 orang (78,3%) memperoleh hasil skor kuesioner skrining Salzburg ≥2. Ditemukan hubungan yang signifikan (p = 0,035) antara skor Salzburg untuk mendeteksi PPOK dengan kadar marker inflamasi CRP (r = 0,500) di RSUD Waled. Kesimpulan: Terdapat hubungan yang signifikan (p = 0,035) antara kuesioner skrining Salzburg untuk mendeteksi PPOK dengan kadar marker inflamasi CRP (r = 0,500) di RSUD Waled yang menunjukkan bahwa semakin tinggi risiko PPOK dengan hasil skor kuesioner skrining Salzburg ≥2, maka semakin tinggi kadar CRP. Kata kunci: CRP, PPOK, kuesioner skrining Salzburg. ABSTRACT Background: Chronic Obstructive Pulmonary Disease (COPD) is still a disease that threatens all people in Indonesia and in the world. It is important for health workers to screen for COPD using a questionnaire. The Salzburg screening questionnaire is a simple and easy-to-use screening questionnaire for the initial selection of spirometry referrals. CRP is an inflammatory marker that will increase in chronic diseases, one of which is COPD. Objective: To determine the relationship between the Salzburg questionnaire score for detecting COPD and CRP levels at Waled Regional Hospital. Methods: This research is an analytic observational study using a cross sectional research design. The sample used was 23 people using total sampling technique. Results: The results of COPD detection using the Salzburg screening questionnaire at Waled Hospital, out of 23 respondents, as many as 18 people (78.3%) obtained the results of the Salzburg screening questionnaire score ≥2. There was a significant relationship (p = 0.035) between the Salzburg score for detecting COPD and the levels of the inflammatory marker CRP (r = 0.500) at Waled Hospital. Conclusion: There is a significant relationship (p = 0.035) between the Salzburg screening questionnaire for COPD detection and levels of the inflammatory marker CRP (r = 0.500) at Waled Hospital which shows that the higher the risk of COPD with the results of the Salzburg screening questionnaire score ≥2, the higher CRP levels.

Pengaruh Pemberian Ekstrak Daging Buah Mangga (Mangifera Indica.L) Varietas Gedong Gincu Terhadap Kadar Asam Urat Tikus Putih Jantan yang Dibuat Hiperurisemia Brajawikalpa, Rama Samara; Herdwiyanti, Menik; Marfuati, Sri; Rahayu, Esa Giri; Pitaloka, Amalia Dwi Ayu; Albab, Arthur Ulil
Malahayati Nursing Journal Vol 6, No 3 (2024): Volume 6 Nomor 3 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i3.12939

ABSTRACT Indonesia has produced many new herbal medicines made from natural ingredients. One of them is the Mango (Mangifera indica L.) gedong gincu variety which has unique phytochemical content including high levels of vitamin C, flavonoids and antioxidants. Flavonoids are known to inhibit xanthine oxidase so they can be used as an alternative treatment for gout. To analyze the effect of administering gedong gincu variety mango (Mangifera indica L.) extract on the uric acid levels of white rats that cause hyperuricemia. This is experimental study with pre and post test research design and control group. using 25 male white rats (Rattus norvegicus) Sprague Dawley strain divided into 5 groups, as normal control group (KK1), positive control (KK2), control and 3 experimental groups (KP) received gedong gincu mango pulp extract with doses of 75, 150, and 300 mg/200grBW rats. The data was tested using a One way ANOVA and Post Hoc. There was a statistical difference between before and after being given gedong gincu mango extract from KP 1, KP 2, and KP 3 (p<0.05) and a decrease in uric acid levels (p<0.05) of 3.83, 4.084, and 4.248 mg/dl. Conclusion: There was a significant difference in the uric acid levels of the treatment groups, where gedong gincu mango peel extract at a dose of 300mg/200grBB had the most effective results compared to other doses. Keywords: Hyperuricemia, Mangifera Indica L, Extract of Gedong Gincu Mango Flesh ABSTRAK Indonesia banyak melahirkan obat-obat herbal baru yang berbahan dasar dari alam. Salah satunya adalah Mangga (Mangifera indica L.) varietas gedong gincu yang memiliki kandungan fitokimia yang khas diantaranya, kandungan vitamin C, flavonoid dan antioksidan yang tinggi tinggi. Flavonoid diketahui dapat menghambat xantin oksidase sehingga dapat dijadikan sebagai alternatif pengobatan pada penyakit asam urat. Menganalisis pengaruh pemberian ekstrak buah mangga (Mangifera indica L.) varietas gedong gincu terhadap kadar asam urat tikus putih yang dibuat hiperurisemia. Penelitian ini bersifat eksperimental dengan rancangan penelitian pre and post test with control group design dengan menggunakan 25 tikus Putih (Rattus norvegicus) jantan galur Sprague dawley yang dibagi menjadi 5 kelompok, yaitu kelompok kontrol normal (KK1), kontrol positif (KK2), dan 3 kelompok perlakuan (KP) yang mendapat ekstrak daging buah mangga gedong gincu dengan dosis bertingkat 75, 150, dan 300 mg/200grBB tikus. Data diuji menggunakan uji one-way ANOVA dan post hoc. Terdapat perbedaan antara sebelum dan sesudah diberikan ekstrak buah mangga gedong gincu dari KP 1, KP 2, dan KP 3 secara statistik (p<0,05) dan penurunan kadar asam urat (p<0,05) sebesar 3,83, 4,084, dan 4,248 mg/dl. Terdapat perbedaan bermakna dari kadar asam urat kelompok perlakuan, dimana ekstrak kulit buah mangga gedong gincu dosis 300mg/200grBB memiliki hasil yang paling efektif dibandingkan dengan dosis lainnya. Kata Kunci: Hiperurisemia, Mangifera Indica L, Ekstrak Daging Buah Mangga Gedong Gincu

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