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All Journal Proceedings of the International Conference on Applied Science and Health Global Health Management Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Tunas Medika Jurnal Kedokteran & Kesehatan The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Ahmad Fariz Malvi Z Zein
Fakultas Kedokteran Universitas Swadaya Gunung Jati
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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HUBUNGAN USIA, JENIS KELAMIN, RIWAYAT KELUARGA, OBESITAS DAN AKTIVITAS FISIK DENGAN HIPERTENSI DI PUSKESMAS KALITANJUNG KOTA CIREBON Ahmad Fariz Malvi Z Zein; Hendy Ekananda Saputra
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 2, No 4 (2015): Tunas Medika Jurnal Kedokteran & Kesehatan
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Hipertensi atau yang lebih dikenal dengan nama penyakit darah tinggi adalah suatu keadaan di mana terjadipeningkatan tekanan darah di atas ambang batas normal yaitu 120/80mmhg. Hipertensi adalah faktor risikoutama penyakit-penyakit kardiovaskular yang merupakan penyebab kematian tertinggi di Indonesia. Datapenelitian Departemen Kesehatan RI menunjukkan hipertensi dan penyakit kardiovaskular masih cukup tinggidan bahkan cenderung meningkat seiring dengan gaya hidup yang semakin kurang sehat. Insidensi hipertensimeningkat seiring dengan pertambahan umur dan usia lanjut, faktor gender, dan aktivitas. Tujuan penelitian iniuntuk mengidentifikasi hubungan usia, jenis kelamin, riwayat keluarga, obesitas dan aktivitas fisik denganhipertensi di Puskesmas Kalitanjung Kota Cirebon. Jenis penelitian yang digunakan adalah penelitian observasidengan desain Cross sectional yaitu suatu penelitian untuk mempelajari dinamika korelasi antara faktor-faktorrisiko dengan efek, dengan cara pendekatan, observasi atau pengumpulan data sekaligus pada satu waktu. Besarsampel sebanyak 40 pasien. Analisis data menggunakan uji korelasi rank spearman. Hasil penelitianmenunjukan bahwa semua variabel bebas yaitu usia, jenis kelamin, riwayat keluarga, obesitas dan aktivitas fisikmempunyai hubungan yang bermakna dengan hipertensiKata Kunci : Hipertensi, Usia, Jenis Kelamin, Riwayat Keluarga, Obesitas, Aktivitas FisikABSTRACTHypertension, or better known as high blood pressure is a condition where an increase of blood pressure abovethe normal threshold of 120 / 80mmHg. Hypertension is a major risk factor for cardiovascular disease which isthe leading cause of death in Indonesia. Ministry of Health research data indicate hypertension andcardiovascular disease is still quite high and even tends to increase with lifestyles less healthy.The incidence ofhypertension increases with age and old age, gender factors, and activity. The aim of research To identify therelationship of age, gender, family history, obesity and physical activity with hypertension in the Public HealthCenters Kalitanjung Cirebon.This type of research is observational research with cross sectional design of astudy to study the dynamics of the correlation between risk factors with effects, the approach, observation ordata collection at once at a time, with samples taken 40. Analyzing data use rank spearman test. From allindependent variables were taken, it was found the presence of all meaningful relationships with hypertension.This means that all independent variables (age, gender, family history, obesity and physical activity) associatedwith hypertensionKeywords: Hypertension, Age, Gender, Family History, Obesity, Physical Activity
THE IMPLEMENTATION OF INTEGRATED-APPROACH ON GERD (I-AGE) PROJECT IN FISHERMEN AS A MODEL OF INTERRELATION OF RESEARCH-BASED HEALTHCARE AND TEACHING Ahmad Fariz Malvi Zamzam Zein
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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THE IMPLEMENTATION OF INTEGRATED-APPROACH ON GERD (IAGE) PROJECT IN FISHERMEN AS A MODEL OF INTERRELATION OF RESEARCH-BASED HEALTHCARE AND TEACHING Ahmad Fariz Malvi Zamzam Zein
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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THE COMPARISON OF DIARRHEA INCIDENCE BETWEEN 0-6 MONTHS OLD INFANTS WHO WERE EXCLUSIVELY BREASTFED, NON-EXCLUSIVELY BREASTFED AND GIVEN MILK FORMULA IN CIREBON CITY, INDONESIA Dewi Sukmawati; Witri Pratiwi; Ahmad Fariz Malvi
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Infant diarrhea is one of the major health issues in Indonesia due to its high incidence and mortality. In 2015, the mortality rate of diarrhea and gastroenteritis in infants under one year in hospitals in Cirebon was 21%. Inappropriate infant feeding practice is one of the risk factors of diarrhea in infants. WHO recommends that every infant should get exclusive breastfeeding during the first 6 months of life and continued breastfeeding until 24 months of age. The aim of this study is to findout the difference in diarrhea incidence between 0-6 months old infants who were exclusively breastfed, non-exclusively breastfed, and given infant milk formula. Methods: This was an observational study with cross-sectional design. A total of 89 infants aged 0-6 months old were recruited by purposive sampling. The primary data were obtained using questionnaires that were filled by the mother or caregiver of the infants. The data were analyzed using the Chi-Square test and Prevalence Ratio was calculated. Results: The Chi-Square test showed a significant difference in diarrhea incidence between 0-6 months old infants who were exclusively breastfed, non-exclusively breastfed and infant milk formula (p=0,028). Infants who were not breastfed have 4 times higher risk of diarrhea (PR=4.145; CI95%= 1.198-14.400) compared to infants who were breastfed. Infants who were not exclusively breastfed has 3 times higher risk of diarrhea incidence compared to the infants receiving exclusive breastfeeding(RP=3.286; CI95%=1.144-9.434) Conclusion: Proper breastfeeding practice can decrease diarrhea incidence in infants aged 0-6 months. Mothers should be encouraged to exclusively breastfeed her baby during the first 6 months of life. Keywords: Diarrhea, breastfeeding, infant milk formula, infant feeding practice
EFFECTIVENESS OF ORALLY USE TILAPIA (Oreochromis niloticus) ON WOUND LENGTH AND FIBROBLAST DENSITY ON INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sayyidah Vina Syauqia; A. Fariz Malvi Zamzam Zein; Tiar M. Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The incidence of a wound in Indonesia has increased from 7.5 percent in 2007 to 8.2 percent in 2013 according to Riskesdas. Wound care that widely used is povidone-iodine, but in case, it has a toxic effect on healthy cells around the wound. The albumin, amino acids, and fatty acids in Tilapia (Oreochromis niloticus) are the potential substances to accelerate the wound healing process. This study aims to investigate the efficacy of Tilapia (Oreochromis niloticus) on wound length and fibroblast density on the incision wound of Wistar rat (Rattus norvegicus). Methods: The study was conducted in the Food and Nutrition PAU Laboratory and Pathology Anatomy Laboratory of Universitas Gadjah Mada, Yogyakarta. This post-test only control group design experimental study used 30 male white rats that randomly divided into five groups, i.e. control group K, and treatment group P1, P2, P3 and P4 that were each given Tilapia with a dose of 12.5 mg/200gBW, 25 mg/200gBW, 37.5 mg/200gBW dan 50 mg/200gBW. The length of the wound was measured by a ruler each day. The rats were terminated on the 10th day to obtain wound tissue for H&E stained histopathological sections to observe fibroblast density. One Way ANOVA, Tamhane, Kruskal-Wallis and Mann Whitney tests were used to compare the wound length and fibroblasts density. Results: Incision wounds in this study showed the best wound healing on the 10th day. Based on the theory, on the 10th day, a proliferation and remodeling phase occurs. There is an effect of giving Tilapia (Oreochromis niloticus) orally at a different dose. Tilapia at dose 37.5mg/200gBW is more effective compared with the dose of 12.5mg/200gBW, 25mg/200gBW, and 50mg/200gBW to accelerate wound healing for wound length and fibroblast density in Wistar rat (Rattus norvegicus). Conclusion: Consuming Tilapia (Oreochromis niloticus) could be a new alternative for wound healing treatment. The antimicrobial ability of Tilapia should be analyzed. Keywords: wound healing, wound length, fibroblast density, Tilapia, Oreochromis niloticus
The Association Between the Pattern of Electronic Cigarette Smoking and Gastroesophageal Reflux Ahmad Fariz Malvi Zamzam Zein; Donny Nauphar; Uswatun Khasanah; Tiar M Pratamawati; Rama S Brajawikalpa; Eka Ayuningtyas; Alif Hamzah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 1 (2021): VOLUME 22, NUMBER 1, April 2021
Publisher : The Indonesian Society for Digestive Endoscopy

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Abstract

Background: This study was aimed to investigate the proportion of gastroesophageal reflux (GER) among electronic cigarette (e-cig) smokers and its association with the pattern of e-cig smoking.Method: This cross-sectional study underwent among e-cig smokers community in Cirebon City, Jawa Barat, ranged from March to August 2020. Subjects were enrolled through consecutive sampling method. The data collection used survey containing the pattern of e-cig smoking and GER. The pattern of e-cig smoking included the duration of e-cig smoking and the amount of e-cig smoking. Gastroesophageal reflux consisted of GER-related symptoms (heartburn, regurgitation, and nocturnal symptom) and gastroesophageal reflux disease (GERD). GERD was defined as GERD questionnaire score cut-off 8. Data analysis used chi square test. This study has been approved by The Medical Research Ethics Committee, Faculty of Medicine, Universitas Swadaya Gunung Jati.Results: There were 273 respondents in this study. The proportion of heartburn was 6.6%, 10.3% for regurgitation, 3.7% for nocturnal symptom, and 5.5% for GERD. There was no association between duration of e-cig smoking and heartburn (p 0.681), regurgitation (p 0.568), nocturnal symptom (p 0.764), and GERD (p 0.113). There was no association between amount of e-cig smoking and heartburn (p 0.062), regurgitation (p 0.770), nocturnal symptom (p 0.985), and GERD (p 0.605).Conclusion: There was relatively low proportion of GER among e-cig smokers. There was no association between the pattern of e-cig smoking and GER in this study.
The prevalence and habit-associated risk factors of gastroesophageal reflux disease among fishermen in Indonesia Ahmad Fariz Malvi Zamzam Zein; Catur Setiya Sulistiyana; Tissa Octavira Permatasari; Uswatun Khasanah; Tiar Masykuroh Pratamawati; Ismayanti Ismayanti; Dwi Listiany Corneli; Eni Suhaeni
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 3 (2021): VOLUME 22, NUMBER 3, December 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2597.373 KB) | DOI: 10.24871/2232021174-179

Abstract

Background. This study was aimed to investigate the prevalence and habit-associated risk factors of gastroesophageal reflux disease (GERD) among fishermen.Methods. A cross-sectional study was conducted among 168 adult fishermen in Cirebon Regency, West Java, Indonesia. A self-administered questionnaire was given. The questionnaire consisted of demographic characteristics and validated GERD questionnaire (GERDQ) in Indonesian language. Data were analyzed using descriptive statistics and chi-square test. The study has been approved by the Medical Research Ethic Comiittee.Results. The medan age of the participants was 39.0 (24-86) years old. They were predominanty (60.7%) female. The prevalence of GERD was 22.6%. According to bivariate analysis, there was association between smoking (PR 1.181; 95%CI 1.013-1.377;p 0.041), high-salt intake (PR 2.419;95%CI 1.079-5.424; p 0.029), herb consumption (PR 3.068; 95%CI 1.307-7.200; p 0.008), poor hand hygiene (PR 3.202; 95%ci 1.445-7.095; p 0.003), and non-steroidal anti-inflammatory drug (NSAID) consumption (PR 3.062; 95%CI 1.446-6.488; p 0.00) with GERD. Tea consumption, coffee consumption, and raw vegetable eating were not associated with GERD.Conclusions This population-based study showed that the prevalence of GERD among fishermen in Indonesia is high. Habits associated with GERD in this study were smoking, high-salt intake, herb consumption poor, hand hygiene,
Hubungan Polimorfisme M235T Gen AGT dengan Inflamasi Pembuluh Darah pada Pasien Hipertensi Esensial Apriliani Nur Puspita Sari; Tiar Masykuroh Pratamawati; Ahmad Fariz Malvi Zamzam Zein
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 8, No 2 (2022): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Latar Belakang: Hipertensi menyebabkan 7,5 juta kematian per tahun dan menyumbang sekitar 12,8% dari total seluruh kematian di dunia. Salah satu patogenesis dari penyakit ini adalah gangguan regulasi sistem renin-angiotensin-aldosteron (RAAS) yang diduga diperantarai salah satunya oleh polimorfisme M235T di daerah promoter gen angiotensinogen (AGT). Beberapa penelitian juga menunjukkan bahwa peningkatan tekanan darah dapat terjadi melalui mekanisme inflamasi yang menyebabkan ketidakseimbangan vasokonstriktor dan vasodilator, trombogenesis, dan aktivasi trombosit. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan polimorfisme M235T gen AGT dengan inflamasi pembuluh darah pada pasien hipertensi esensial. Metode: Penelitian observasional analitik dengan desain potong lintang yang dilakukan di Puskesmas Plumbon dan melibatkan 50 orang. Data diperoleh dengan cara pemeriksaan menggunakan PCR-RFLP dan pemeriksaan hitung darah lengkap. Analisis data dilakukan dengan metode koefisien kontingensi dan perhitungan rasio prevalensi. Hasil: Mayoritas subjek penelitian ini memiliki polimorfisme M235T (94%) dan mengalami inflamasi pembuluh darah (66%). Hasil analisis menunjukkan bahwa secara statistik hubungan antara polimorfisme M235T gen AGT dengan inflamasi pembuluh darah tidak bermakna (p = 0,218), tetapi hasil perhitungan rasio prevalensi menunjukkan penderita hipertensi esensial dengan polimorfisme M235T gen AGT berisiko untuk mengalami inflamasi pembuluh darah. (PR = 2,06). Kesimpulan: Tidak didapatkan hasil yang bermakna pada hubungan polimorfisme M235T gen AGT dengan inflamasi pembuluh darah pada pasien hipertensi esensial. Kata Kunci: polimorfisme M235T gen AGT; inflamasi vaskular; PLR, hipertensi. ABSTRACT Background: Hypertension causes 7.5 million deaths per year and accounts for around 12.8% of all world deaths. One of the pathogenesis of this disease is the disruption of the regulation of the renin-angiotensin-aldosterone system (RAAS) which is thought to be mediated one of them by the M235T polymorphism in the angiotensinogen gene promoter (AGT) region. Some studies also show that increased blood pressure can occur through inflammatory mechanisms that cause vasoconstrictor and vasodilator imbalances, thrombogenesis, and platelet activation. Aim: This study aims to determine the relationship of M235T polymorphism of AGT gene with vascular inflammation in patients with essential hypertension. Methods: An analytic observational study with cross sectional design conducted at Puskesmas Plumbon and involved 50 people. Data obtained by PCR-RFLP and complete blood count. Data analysis was performed using the contingency coefficient method and prevalence ratio calculations. Results: The majority of study subjects had M235T polymorphisms (94%) and had vascular inflammation (66%). The analysis showed that statistically, the relationship between M235T polymorphism of AGT gene with vascular inflammation was not significant (p = 0.218) but the prevalence ratio showed that patients with essential hypertension with M235T polymorphism of AGT gene have  a risk of vascular inflammation (PR = 2,06). Conclusion: There is no relationship between M235T polymorphism of AGT gene with vascular inflammation. Keywords: M235T polymorphism of AGT gene; vascular inflammation; PLR; hypertension.
PROFIL STATUS NUTRISI PADA PASIEN KANKER PAYUDARA STADIUM LANJUT PASCA KEMOTERAPI DI RSUD WALED Risa Rafana; Ahmad Fariz Malvi Zamzam Zein; Dini Sapardini Warsodoedi
Tunas Medika Jurnal Kedokteran & Kesehatan Vol 8, No 2 (2022): TUNAS MEDIKA JURNAL KEDOKTERAN & KESEHATAN
Publisher : Tunas Medika Jurnal Kedokteran & Kesehatan

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Kanker adalah suatu penyakit yang disebabkan oleh pertumbuhan sel-sel jaringan tubuh dengan cepat, tidak terkendali, dan akan terus membelah diri, selanjutnya menyusup ke jaringan sekitarnya (invasive) dan menyebar melalui jaringan ikat, darah, dan menyerang organ-organ lainnya, seperti paru, hepar, saraf, dan tulang belakang. Efek samping yang sering timbul pada pasien kemoterapi adalah mual, muntah dan anoreksia. Untuk mengetahui gambaran Indeks Massa Tubuh dan karakteristik  pada pasien kanker payudara stadium lanjut pasca kemoterapi di RSUD Waled. Metode deskriptif menggunakan teknik total sampling. Jumlah sampel yang didapatkan yaitu 18 pasien. Data primer didapatkan dari tinggi badan dan berat badan yang diukur pada pasien dan kuesioner yang diisi oleh pasien yang didapatkan dari RSUD Waled. Berdasarkan Uji Tabulasi Silang menunjukkan bahwa mayoritas subjek penelitian ini termasuk dalam kelompok usia middle age, patuh mengikuti kemoterapi, memiliki nutrisi yang baik, dan memiliki IMT tidak underweight. Pasien kanker payudara stadium lanjut pasca kemoterapi di RSUD Waled memiliki persentase underweight sebesar 38,9%. Pasien kanker payudara stadium lanjut pasca kemoterapi di RSUD Waled mayoritas yang berusia middle age memiliki IMT tidak underweight. Pasien kanker payudara stadium lanjut pasca kemoterapi di RSUD Waled mengikuti kemoterapi dengan patuh sesuai jadwal. Pasien kanker payudara stadium lanjut pasca kemoterapi di RSUD Waled mayoritas memiliki nutrisi yang baik.Kata kunci : Kanker payudara, asupan nutrisi, umur, kemoterapi, faktor resiko kanker. ABSTRACTCancer is a disease caused by the growth of body tissue cells quickly, uncontrolled, and will continue to divide, then infiltrate into surrounding tissue (invasive) and spread through connective tissue, blood, and attack other organs, such as the lungs, liver, nerves and spine. Side effects that often arise in chemotherapy patients are nausea, vomiting and anorexia. To find out the picture of Body Mass Index and characteristics in post-chemotherapy advanced breast cancer patients at RSUD Waled. Descriptive methods using total sampling techniques. The number of samples obtained was 18 patients. Primary data were obtained from height and weight measured in patients and quetionnaires completed by patients obtained from RSUD Waled. Based on the Cross Tabulation Test, it is shown that the majority of subjects in this study belong to the middle age group, adhere to chemotherapy, have good nutrition, and have a BMI not underweight. Patients with advanced-stage breast cancer after chemotherapy at RSUD Waled had an underweight percentage of 38.9%. Patients with advanced-stage breast cancer after chemotherapy at RSUD Waled the majority of those in middle age have a BMI not underweight. Patients with advanced-stage breast cancer after chemotherapy at RSUD Waled follow chemotherapy in accordance with the schedule. The majority of post-chemotherapy advanced breast cancer patients at RSUD Waled have good nutrition. Keywords: Breast cancer, nutritional intake, age, chemotherapy, cancer risk factors.
The Proportion of Acute Transfusion Reaction at Outpatient Blood Transfusion Unit in Tertiary Hospital in Indonesia Zein, Ahmad Fariz Malvi Zamzam; Sukrisman, Lugyanti
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 2
Publisher : UI Scholars Hub

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Introduction. Acute transfusion reaction (ATR) is an important issue related to patient safety. The prevalence of ATR at tertiary hospital in Indonesia is 0.5%. This study was aimed to determine the proportion of ATR in outpatient blood transfusion unit at tertiary hospital. Method. This retrospective study implemented data from medical records of adult patients who underwent blood transfusion in outpatient blood transfusion unit, Cipto Mangunkusumo Hospital between August – October 2014. The blood components included packed red cells (PRC), thrombocyte concentrate (TC), fresh frozen plasma (FFP), and cryoprecipitate. We recorded the administration of premedication and ATR-related symptoms/signs. The ATR report was based on WHO classification. Results. There were 1,010 blood transfusions during the study period. The distribution of blood components were PRC (n=802, 79.4%), PC (n=74, 7.3%), FFP (n=43, 4.3%), and cryoprecipitate (n=91, 9.0%). The premedication was administered in 21 transfusions (2.1%). There were 11 ATRs with WHO category 1 (1.1%), no other categories were reported. Based on blood component, the ATR occurred predominantly in PRC transfusion (0.6%), followed by FFP (0.3%), cryoprecipitate (0.1%), and TC (0.1%), respectively. Conclusion. The proportion of ATR in outpatients blood transfusion unit at Cipto Mangunkusumo Hospital was 1.1%. All reported ATR were category 1 in this study. The ATR was predominantly in PRC transfusion.
Co-Authors Adi, Galang Prasetyo Alif Hamzah Apriliani Nur Puspita Sari Azahra, Afifah Humaira Catur Setiya Sulistiyana Dewi Sukmawati Dini Sapardini Warsodoedi Donny Nauphar Dwi Listiany Corneli Eka Ayuningtyas Eni Suhaeni Hendy Ekananda Saputra Hermansyah Suwarno Hidayat, Abimanyu Ismayanti Ismayanti Lugyanti Sukrisman Luthfi, Ahmad Ichwan Pratiwi, Lusi Rai Rifda Sukma Fairuz Rama S Brajawikalpa Risa Rafana Sayyidah Vina Syauqia Sedayu, Sedayu Suwarno, Hermansyah Tiar Masykuroh Pratamawati Tissa Octavira Permatasari Uswatun Khasanah Witri Pratiwi