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All Journal ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan PharmaCine : Journal of Pharmacy, Medical and Health Science
Lestari, Kharina Septi
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Recent Updates on the Potential of Medicinal Plants from Indonesia as Anti-Atherosclerotic Agents Prasesti, Gayuk Kalih; Narsa, Angga Cipta; Rijai, Akhmad Jaizzur; Lestari, Kharina Septi; Zulkaida, Zulkaida
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52261

Abstract

Atherosclerosis is one of the causes of problems in the cardiovascular system. This condition can be prevented by using natural products, one of which is medicinal plants. This review collects data on medicinal plants that are easily found in Indonesia that can reduce or improve atherosclerosis conditions. There are 10 plants reviewed that have a high level of safety and potential to be developed as medicine. The plant parts used are fruit and leaves. Some are commonly used as cooking spices such as turmeric and garlic which are found to be useful for improving atherosclerosis conditions. In the context of modern drug development, Indonesia holds significant potential for exploring these plants as sources of active compounds for pharmaceutical applications. Scientific studies of these natural materials are crucial for identifying bioactive components and understanding their mechanisms of action. With the right approach, Indonesia's natural resources could form the basis for developing new, safer, and more effective drugs. Additionally, Indonesia has a considerable opportunity in the global market for natural health products, including nutraceuticals and dietary supplements, as global interest in natural health solutions continues to grow.
Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Pratama, Reza; Simamora, Boy Ignatius; Oktriyani, Anissa Nadya
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
POTENSI ANTIATEROGENIK KOMBINASI EKSTRAK ETANOL RIMPANG KUNYIT DAN DAUN PEGAGAN DALAM MENURUNKAN RISIKO PENYAKIT KARDIOVASKULAR PADA MODEL HEWAN TIKUS OBES Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Farihah, Ai Siti; Ramadhan, Dika Azhar; Kaniawati, Marita; Sulaeman, Agus
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2882

Abstract

Obesity is a major risk factor for atherosclerosis and cardiovascular disease, characterized by dyslipidemia and oxidative stress. This study aimed to evaluate the anti-atherogenic effects of a combination of ethanol extracts of turmeric rhizome (Curcuma longa) and gotu kola leaves (Centella asiatica) in obese–hyperlipidemic rats.  Male rats were divided into seven groups: normal, induction, comparator (orlistat 10.8 mg/kgBW), and treatment groups receiving single and combined extracts (ERK, EDP, ERKDP 200:100, ERKDP 100:200 mg/kgBW). Obesity and hyperlipidemia were induced using a high-fat and fructose diet for 60 days. Parameters measured included body weight, lipid profile (TG, HDL, LDL, total cholesterol), Atherogenic Index of Plasma (AIP), and aortic histology. The induction group showed significant increases in body weight, triglycerides, LDL, and AIP (P<0.05). All treatment groups significantly improved lipid profiles and reduced AIP compared to the induction group. The ERKDP 100:200 mg/kgBW combination showed the most optimal effect, with a 51.83% reduction in LDL, a 54.60% decrease in AIP, and a 146% increase in HDL. Histological analysis also demonstrated reduced foam cell formation and improved aortic structure in this group. In conclusion, the combination of turmeric and gotu kola extracts, particularly at a dose of 100:200 mg/kgBW, exhibits significant anti-atherogenic potential through lipid profile improvement, AIP reduction, and vascular protection.
Inovasi Pengolahan Tanaman TOGA Jahe menjadi Minuman Granul Fungsional Bernilai Kesehatan dan Ekonomi Lestari, Kharina Septi; Asnawi, Aiyi; Purwaniati, Purwaniati; Pahlevi, Muhamad Reza; Aligita, Widhya; Kosasih, Kosasih
Jurnal Abdimas Kartika Wijayakusuma Vol 7 No 1 (2026): Jurnal Abdimas Kartika Wijayakusuma (in Progress)
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v7i1.1240

Abstract

RW 09 Cipadung Kidul Panyileukan dalam kegiatan pengabdian kepada masyarakat ini merupakan kelompok warga yang telah memiliki Taman Tanaman Obat Keluarga (TOGA), namun pemanfaatannya masih terbatas untuk kebutuhan konsumsi rumah tangga. Jahe sebagai komoditas utama TOGA belum dikembangkan menjadi produk bernilai tambah karena keterbatasan pengetahuan, keterampilan teknis, serta pemahaman mengenai aspek higienitas, pengemasan, dan potensi ekonomi produk herbal. Program ini bertujuan untuk mengoptimalkan pemanfaatan TOGA melalui pengolahan jahe menjadi minuman granul fungsional yang praktis dan memiliki nilai jual. Metode pelaksanaan mencakup edukasi mengenai manfaat jahe dan keamanan pangan, pelatihan teknis pembuatan minuman granul jahe secara higienis, serta pendampingan dalam proses pengemasan dan penyimpanan produk. Evaluasi kegiatan dilakukan melalui pre-test, post-test, dan observasi langsung terhadap peserta. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan dan keterampilan masyarakat dalam memproduksi minuman granul jahe, tersedianya produk contoh siap saji, serta tersusunnya modul panduan pembuatan produk. Selain itu, kegiatan ini juga dipublikasikan melalui berbagai media dan difasilitasi pendaftaran Hak Kekayaan Intelektual (HKI) sebagai bentuk perlindungan terhadap inovasi yang dihasilkan. Melalui program ini, diharapkan kesehatan masyarakat dapat meningkat sekaligus membuka peluang usaha berbasis potensi lokal secara berkelanjutan.
Co-Authors Agus Sulaeman Aiyi Asnawi Aligita, Widhya Angga Cipta Narsa Farihah, Ai Siti Istiqomah, Aulia Nurfazri KOSASIH KOSASIH, KOSASIH Marita Kaniawati Oktriyani, Anissa Nadya Pahlevi, Muhamad Reza Prasesti, Gayuk Kalih Pratama, Reza Purwaniati, Purwaniati Ramadhan, Dika Azhar Rijai, Akhmad Jaizzur Simamora, Boy Ignatius Zulkaida, Zulkaida