Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal ad-Dawaa : Journal of Pharmaceutical Sciences PharmaCine : Journal of Pharmacy, Medical and Health Science
Lestari, Kharina Septi
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Recent Updates on the Potential of Medicinal Plants from Indonesia as Anti-Atherosclerotic Agents Prasesti, Gayuk Kalih; Narsa, Angga Cipta; Rijai, Akhmad Jaizzur; Lestari, Kharina Septi; Zulkaida, Zulkaida
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52261

Abstract

Atherosclerosis is one of the causes of problems in the cardiovascular system. This condition can be prevented by using natural products, one of which is medicinal plants. This review collects data on medicinal plants that are easily found in Indonesia that can reduce or improve atherosclerosis conditions. There are 10 plants reviewed that have a high level of safety and potential to be developed as medicine. The plant parts used are fruit and leaves. Some are commonly used as cooking spices such as turmeric and garlic which are found to be useful for improving atherosclerosis conditions. In the context of modern drug development, Indonesia holds significant potential for exploring these plants as sources of active compounds for pharmaceutical applications. Scientific studies of these natural materials are crucial for identifying bioactive components and understanding their mechanisms of action. With the right approach, Indonesia's natural resources could form the basis for developing new, safer, and more effective drugs. Additionally, Indonesia has a considerable opportunity in the global market for natural health products, including nutraceuticals and dietary supplements, as global interest in natural health solutions continues to grow.
Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Pratama, Reza; Simamora, Boy Ignatius; Oktriyani, Anissa Nadya
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Co-Authors Angga Cipta Narsa Istiqomah, Aulia Nurfazri Oktriyani, Anissa Nadya Prasesti, Gayuk Kalih Pratama, Reza Rijai, Akhmad Jaizzur Simamora, Boy Ignatius Zulkaida, Zulkaida