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All Journal Jurnal Pengabdian Masyarakat AbdiMas Berkala Ilmiah Mahasiswa Farmasi PharmaCine : Journal of Pharmacy, Medical and Health Science
Istiqomah, Aulia Nurfazri
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Aktivitas Ekstrak Daun Keji Beling (Strobilanthes crispus Blume.) Pada Model Hewan Resistensi Insulin yang Diinduksi Pakan Tinggi Lemak dan Fruktosa Istiqomah, Aulia Nurfazri
Berkala Ilmiah Mahasiswa Farmasi Indonesia Vol. 10 No. 2 (2023): Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI)
Publisher : Ikatan Senat Mahasiswa Farmasi Seluruh Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48177/bimfi.v10i2.114

Abstract

Introduction: Various herbal plants are known to have activity towards increasing insulin sensitivity so that they have the potential to be used for the treatment of diabetes. One of the medicinal plants with this activity is the keji beling leaves (Strobilanthes crispus Blume). Several previous studies have used animal models of insulin resistance due to consumption of high- fat and fructose foods. Therefore, the purpose of this study was to determine the activity of ethanol extract of keji beling leaves on increasing insulin sensitivity in animal models of insulin resistance induced by high-fat and fructose diets. Methods: The method used to create insulin resistance animal models is by giving a high-fat and fructose diet 1800 mg/kgBB preventively for 42 days. The test animals were grouped into 6 groups, namely the negative control group, positive control, metformin 45mg/kgBW, Keji Beling Leaf Ethanol Extract 75mg/kgBB, 150mg/kgBW and 300mg/kgBW. The parameters observed were the value of fasting blood glucose levels on days 0 and 42 and the constant value of the insulin tolerance test (KTTI) on days 0, 21 and 42. Result: Ethanol extract of keji beling leaves had activity towards increasing insulin sensitivity, namely the dose of 75 mg/kgBW with an average reduction value of 12.57, a dose of 150 mg/kg BW with a value of 14.88 and a dose of 300 mg/kg BW with a value of 17.66. Conclusion: The ethanol extract of keji beling leaves has activity in increasing insulin sensitivity with the most effective dose being 150 mg/kgBW.
DAUR ULANG MINYAK JELANTAH : EDUKASI DAN PEMANFAATAN LIMBAH MENJADI PRODUK RAMAH LINGKUNGAN Istiqomah, Aulia Nurfazri; Pratama, Reza
Jurnal Pengabdian Masyarakat AbdiMas Vol 11, No 03 (2025): Jurnal Pengabdian Masyarakat Abdimas
Publisher : Universitas Esa Unggul

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47007/abd.v11i03.8783

Abstract

Minyak jelantah, yang sering dianggap sebagai limbah rumah tangga, dapat memberikan dampak buruk terhadap lingkungan jika tidak dikelola dengan baik. Namun, limbah ini memiliki potensi untuk didaur ulang menjadi produk bermanfaat seperti sabun. Tim dosen Fakultas Farmasi Universitas Bhakti Kencana melaksanakan edukasi dan pelatihan di Desa Majasetra, Kecamatan Majalaya, Kabupaten Bandung, untuk meningkatkan kesadaran masyarakat terkait pengelolaan minyak jelantah. Kegiatan ini melibatkan pengumpulan bahan pada 15 November 2024 dan pelaksanaan edukasi serta pelatihan pada 21 November 2024. Hasil kuisioner menunjukkan adanya peningkatan signifikan pada pemahaman warga mengenai risiko penggunaan minyak jelantah berulang dan cara pengolahannya menjadi sabun. Pendekatan ini tidak hanya mengedukasi warga tentang pentingnya pengelolaan limbah rumah tangga, tetapi juga membekali mereka dengan keterampilan praktis untuk menghasilkan produk ramah lingkungan yang bernilai ekonomis. Edukasi ini diharapkan dapat berkontribusi pada keberlanjutan lingkungan dan pemberdayaan masyarakat.
Uji Toksisitas Subkronik Ekstrak Etanol Daun Sidaguri (Sida Rhombifolia L.) Terhadap Fungsi Hati dan Ginjal Pada Tikus: Subchronic Toxicity of Ethanol Extract of Sidaguri Leaves (Sida Rhombifolia L.) on Liver and Kidney Function in Rats Lestari, Kharina Septi; Istiqomah, Aulia Nurfazri; Pratama, Reza; Simamora, Boy Ignatius; Oktriyani, Anissa Nadya
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 6 No. 2 (2025): PharmaCine: Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v6i2.13177

Abstract

Sidaguri leaves (Sida rhombifolia L.) have been widely used in traditional medicine due to their anti-inflammatory, diuretic, and analgesic properties. To ensure their safety, a subchronic toxicity study was conducted using ethanolic extracts of Sida rhombifolia leaves. The study involved male and female Wistar rats administered a dose of 14 mg/kg body weight (BW) daily for 90 days. Toxic symptoms were observed throughout the study period, followed by organ weight assessment, blood biochemical analysis (SGOT, SGPT, creatinine, and urea), and histological examination of heart and kidney tissues. The results showed no toxic symptoms or mortality in the test animals. Levels of SGOT, SGPT, creatinine, and urea remained within normal limits, with no statistically significant differences (p>0.05) between the control and treatment groups. Histological analysis revealed no signs of necrosis in heart and kidney tissues. In conclusion, the ethanolic extract of Sida rhombifolia leaves at a dose of 14 mg/Kg BW is non-toxic and considered safe for daily consumption. Keywords: Sidaguri leaves; Subchronic toxicity;  Histologic;  Liver;  Kidney.
Co-Authors Lestari, Kharina Septi Oktriyani, Anissa Nadya Pratama, Reza Simamora, Boy Ignatius