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All Journal JURNAL KESEHATAN YAMASI MAKASSAR Journal of Pharmaceutical Science and Herbal Technology Jurnal Kesehatan Qamarul Huda
Muhammad Asri SR
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL TUNAS REBUNG (Bambusa SP) PADA KAKI TIKUS WISTAR JANTAN YANG DIINDUKSI KARAGENAN Muhammad Asri SR; Winarni; Nielma Auliah; Nurjannah Bachri
Journal of Pharmaceutical Science and Herbal Technology Vol. 8 No. 2 (2023): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35892/jpsht.v1i1.1455

Abstract

Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol tunas rubung (Bambusa SP) memiliki aktivitas sebagai antiinflamasi pada tikus Jantan galur wistar dan berapa konsentrasi yang paling efektif dari ekstrak etanol tunas rebung (Bambusa SP) yang memberikan aktivitas antiinflamasi yang dilihat dari dari parameter penurunan edema pada kaki tikus. Metode penelitian secara eksperimental dengan cara tikus putih Jantan galur wistar sebanyak 15 ekor diinduksi dengan karagenan yang dibagi menjadi 5 kelompok, masing-masing kelompok terdiri dari 3 ekor. Kelompok control negatif diberikan Na-CMC dan control positif diberikan natrium diklofenak. Kelompok I diberikan ekstrak dengan konsentrasi 2%, kelompok II diberikan ekstrak dengan konsentrasi 4% dan untuk kelompok III diberikan ekstrak dengan konsentrasi 6%. Hasil penelitian menunjukkan bahwa : 1. Efek antiinflamasi dari ekstrak tunas rebung sangat kuat 2. Pemberian ekstrak etanol tunas rebung (Bambusa SP) berpengaruh terhadap penurunan edema pada kaki tikus Jantan galur wistar 2. Ada perbedaan pengaruh pemberiaan dosis terhadap penurunan edema pada kaki tikus Jantan galur wistar.
UJI AKTIVITAS FRAKSI N-HEKSAN, ETIL ASETAT, ETANOL DAUN PARE (Momordica charantia L.) TERHADAP Staphylococcus epidermidis DAN Salmonella thypi Muhammad Asri SR; Suryanita; Kasim, Rezky Amaliah
Jurnal Kesehatan Yamasi Makassar Vol 9 No 2 (2025): Jurnal Kesehatan
Publisher : Akademi Farmasi Yamasi Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59060/jurkes.v9i2.380

Abstract

Bitter melon leaves (Momordica charantia L.) contain compounds such as flavonoids, saponins, triterpenoids, glycosides and alkaloids. This study aims to determine the difference in antibacterial activity of the N-hexane, Ethyl acetate and Ethanol 96% fractions fram bitter melon leaves (Momordica charantia L.) against the bacteria Staphylococcus epidermidis and Salmonella thypi. The research method is an experimental study to see the antibacterial activity of the N-hexane, ethyl acetate and etanol 96% fractions at concentrations of 5%, 10% and 15% using the disc diffusion method. The results of the research showed that Staphylococcus epidermidis bacteria obtained an inhibitory power of 5% (5,95 mm), 10% (12,23 mm), 15% (14,05 mm) for the N-hexane fraction. Ethyl acetate fraction 5% (6,08 mm), 10% (7,37 mm), 15% (10,93 mm). Ethanol fraction of 5% (6,37 mm), 10% (12,8 mm), 15% (13,98 mm). Salmonella thypi bacteria against the N-hexane fraction obtained an inhibitory power of 5% (7,83 mm), 10% (12,47 mm), 15% (13,88 mm). The ethyl acetate fraction is 5% (5,43 mm), 10% (10,85 mm), 15% (13,88 mm). Ethanol fraction of 5% (7,77 mm), 10% (10,27 mm), 15% (15,5 mm). It can be concluded that the N-hexane, ethyl acetate and ethanol 96% fractions have antibacterial activity.
Aktivitas Imunodulator Fraksi Etil Asetat Daun Jamblang (Syzgium cumini L) Pada Tikus Putih Jantan (Rattus norvegicus L) Yang Telah Diinfeksi Staphylococcus aureus Muhammad Asri SR; Rudia Tamaria; Suryanita
Jurnal Kesehatan Qamarul Huda Vol. 12 No. 2 (2024): Desember 2024
Publisher : Universitas Qamarul Huda Badaruddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37824/jkqh.v12i2.2024.672

Abstract

The immune system functions to protect the body from foreign substances such as microorganisms, bacteria, viruses and parasites. The immune system can be enhanced by administering immunomodulators. This study aims to determine the immunomodulatory activity of the jamblang leaf fraction (Syzgium cumini L) in male white rats (Rattus norvegicus L) that have been infected with Staphylococcus aureus. The extract was prepared by fractionation using ethyl acetate, ethanol, and n-hexane as solvents. Testing of immunomodulatory activity was carried out by calculating the phagocytic activity value of peritoneal macrophage cells using the Giemsa staining method with 100X magnification on a microscope. Fifteen rats tested were divided into five treatment groups, namely negative control (Na-CMC), positive control (Stimuno® 50 mg), and the extract dose group of 140 mg/kg BW, 210 mg/kg BW, 280 mg/kg BW. The treatment was given orally for 7 consecutive days and intraperitoneal injection of Staphylococcus aureus bacteria was given on day 8 for each group. The results of peritoneal fluid smear studies are used to determine the activity of macrophage cells. Data were analyzed by one way ANOVA test and followed by the HSD post hoc test. Immunomodulatory activity test showed that doses of 140 mg/kg BW, 210 mg/kg BW and 280 mg/kg BW had immunomodulatory activity by showing significant differences with the negative control and positive control groups (p<0.05). Based on the results of the study, it was shown that the immunomodulatory activity test at a dose of 280 mg/kg BW had greater immunomodulatory activity due to the greater number of activated macrophage cells.
Co-Authors Kasim, Rezky Amaliah Nielma Auliah Nurjannah Bachri Rudia Tamaria Suryanita Winarni