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All Journal Hydrogen: Jurnal Kependidikan Kimia Journal of Indonesia Laboratory Students (JILTS)
Fihiruddin
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology

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Pengaruh Jenis Sampel Urine Terhadap Pemeriksaan HCG (Human Chorionic Gonadotropin) Untuk Deteksi Kehamilan Dini Metode Immunokromatografi Wardani, Yuliana; Erlin Yustin Tatontos; Fihiruddin; Yunan Jiwintarum
Journal of Indonesia Laboratory Students (JILTS) Vol. 3 No. 2 (2024): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v3i2.129

Abstract

Latar Belakang : Kehamilan merupakan suatu proses yang akan dialami oleh hampir semua wanita. disaat sel telur bertemu dengan sperma dan terjadi pembuahan dapat menyebabkan kehamilan. Human Chorionic Gonadotropin (HCG) adalah hormone yang diproduksi oleh trophoblast pada awal kehamilan yang dikeluarkan melalui urine. Adanya hormone HCG dalam urine dapat digunakan untuk deteksi kehamilan dini. Urine pagi baik untuk pemeriksaan kehamilan atau deteksi HCG karena, urine pagi merupakan urine satu malam yang mencerminkan periode tanpa asupan cairan yang lama, sehingga urine pagi lebih pekat daripada urin sewaktu yang konsentrasinya lebih encer sehingga sulit untuk mendeteksi hormone HCG. Tujuan Penelitian : Mengetahui pengaruh jenis sampel urine terhadap pemeriksaan Human Chorionic Gonadotropin (HCG) dalam deteksi kehamilan dini metode immunokromatografi. Metode Penelitian : Penelitian ini merupakan penelitian dengan metode observasional analitik dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah wanita yang terlambat menstruasi 1-3 minggu (hamil) pada wilayah kecamatan selong dengan jumlah sampel sebanyak 24 sampel. Analisa data menggunakan Analisa deskriptif. Pada penelitian ini menggunakan metode Immunokromatografi (Testpack). Hasil Penelitian : Didapatkan hasil positif (+) pada 12 sampel urine pagi hari dan didapatkan hasil positif (+) pada 12 sampel urine sewaktu wanita yang terlambat menstruasi 1-3 minggu. Kesimpulan : Tidak terdapat pengaruh jenis sampel urine dalam deteksi HCG menggunakan sampel urine pagi hari dan urine sewaktu pada wanita yang terlambat menstruasi 1-3 minggu.
Hubungan antara Lama Terinfeksi Virus Penderita Hepatitis B dengan Indeks Eritrosit (MCV,MCH,MCHC) Septiani, Erna; Maruni Wiwin Diarti; Erlin Yustin Tatontos; Fihiruddin
Journal of Indonesia Laboratory Students (JILTS) Vol. 3 No. 2 (2024): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v3i2.166

Abstract

Background: Hepatitis B is an infectious disease that attacks the liver caused by the Hepatitis B virus. Hepatitis B virus infection is very infectious and is the main cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B can cause liver cirrhosis, where there is a change in the structure of the liver parenchyma resulting in a decrease in erythrocyte index levels. Objective: To determine the relationship between the duration of viral infection in hepatitis sufferers and the erythrocyte index (MCV, MCH, MCHC) Method: This research is an analytical observational study with a cross sectional approach and accidental sampling technique Results: Based on the results of the Kruskall Wallis test, the relationship between the duration of infection with the hepatitis B virus and the erythrocyte index (MCV, MCH, MCHV) resulted in MCV 75.50, MCH 17.97, MCHC 43.03 with a p value = 0.000 < 0.05. so it can be concluded that there is a relationship between the duration of infection with the hepatitis B virus and the erythrocyte index (MCV, MCH, MCHV) Conclusion: From the results of the analysis carried out, there is a relationship between the duration of infection with the hepatitis B virus and the erythrocyte index (MCV, MCH, MCHV)
Deteksi Cotinine sebagai Penyebab Green Tobacco Sickness (GTS) pada Petani Tembakau di Desa Marong Metode Rapid Diagnostic Test (RDT) Azharin, Intan; Fihiruddin; Danuarti, Maruni wiwin
Journal of Indonesia Laboratory Students (JILTS) Vol. 4 No. 1 (2025): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v4i1.176

Abstract

Latar Belakang: Green Tobacco Sickness (GTS) merupakan keracunan nikotin yang beresiko di alami oleh petani tembakau. Nikotin tersebut berasal dari daun tembakau yang terserap ke permukaan kulit pada saat kontak langsung dengan saat memetik atau mengolah daun tembakau. Nikotin merupakan senyawa alkaloid yang ada di dalam tembakau dengan berat molekul rendah dan kelarutan dalam lemak dan air yang baik sehingga mudah di serap oleh kulit yang mengakibatkan abrasi pada kulit tangan. Cotinine sering digunakan sebagai biomarker dalam pemeriksaan paparan nikotin terhadap petani. Tujuan Penelitian: Untuk mendeteksi cotinine pada petani tembakau sebagai penyebab Green  Tobacco Sickness (GTS) di desa marong metode Rapid Diagnostic Test (RDT). Metode Penelitian: Penelitian ini bersifat observasional deskriptif dengan rancangan cross sectional. Dilaksanakan pada bulan Oktober 2023 – Maret 2024 dengan populasi 354 orang di dusun karang payung, tehnik pengambilan sampel simple random sampling dengan jumlah sampel 24 urin petani tembakau dan selanjutnya di analisis dengan obsevasional deskriptif. Hasil Penelitian: Hasil penelitian menunjukkan deteksi cotinine pada petani tembakau dengan responden 24 menunjukkan hasil positif dengan gejala yang dialami seperti mual, muntah, pusing,kelahan dan kelemahan tubuh yang berlebih,denyut jantung tidak normal, kram perut dan suhu tubuh tidak normal. Kesimpulan: Cotinine terdeteksi pada semua sampel urine petani di Desa Marong menggunakan Rapid Diagnostic Test (RDT).Green Tobacco Sickness (GTS), Nikotin, Tembakau.
Relationship between Cholesterol Levels and Ca 15-3 Tumor Markers in Patients with Carcinoma Mammae Faylori, Adelia Yusnita; Pauzi, Iswari; Fihiruddin
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.17460

Abstract

Breast cancer is the most common malignancy among women worldwide and remains a major cause of cancer-related mortality in Indonesia. Various risk factors, including hormonal, genetic, lifestyle, and metabolic factors, such as elevated cholesterol levels, have been associated with the development and progression of breast cancer. Cholesterol plays a crucial role in cell membrane formation and hormone synthesis, and recent studies have suggested its potential role in tumor growth and metastasis, particularly through the modulation of estrogen receptors and inflammatory pathways. CA 15-3 is a tumor marker widely used for monitoring breast cancer progression and recurrence. However, the correlation between cholesterol levels and CA 15-3 remains underexplored. The research objective is to determine the correlation between total cholesterol levels and the breast cancer tumor marker CA 15-3 in patients diagnosed with breast carcinoma at the Regional General Hospital of West Nusa Tenggara Province (RSUDP NTB). A cross-sectional analytic observational study was conducted using secondary data from the medical records of 33 breast carcinoma patients collected between January to November 2024. Cholesterol and CA 15-3 levels were analyzed using standard laboratory procedures. Data distribution was tested using the Kolmogorov-Smirnov test, and Pearson correlation analysis was applied to evaluate the relationship between cholesterol levels and CA 15-3. Showed that the mean cholesterol level was 214.24 mg/dL, and the mean CA 15-3 level was 41.55 U/mL, both exceeding normal reference values. Pearson correlation analysis demonstrated a very strong and statistically significant positive correlation between total cholesterol and CA 15-3 levels (r = 0.940, p < 0.001), indicating that higher cholesterol levels are associated with increased CA 15-3 concentrations. The study found a significant correlation between cholesterol levels and CA 15-3 in breast carcinoma patients, suggesting that cholesterol may influence tumor activity. Routine monitoring of cholesterol levels may be valuable in the clinical management of breast cancer, especially in assessing disease progression.
Co-Authors Azharin, Intan Danuarti, Maruni wiwin Erlin Yustin Tatontos Faylori, Adelia Yusnita Maruni Wiwin Diarti Pauzi, Iswari Septiani, Erna Yuliana Wardani Yunan Jiwintarum