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All Journal Indonesian Journal of Dental Medicine Bhakta Dental Journal
Hanif, Hilmy Irsyadi
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Curcumin induces tumor suppression in ameloblastoma by promoting apoptotic mechanism via MiR-9 expression: A narrative review Hanif, Hilmy Irsyadi; Hardiyani, Reisca Tiara; Septiani, Intan Dzahabiyah; Susilowati, Heni
Indonesian Journal of Dental Medicine Vol. 7 No. 2 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i2.2024.87-93

Abstract

Background: Ameloblastoma is a neoplastic odontogenic tumor that has a local invasive characteristic. The current treatment for ameloblastoma requires a precise surgical resection and chemotherapy. It requires a different approach to diminish the therapy drawbacks. Curcumin, as one of the most common well-described compounds, remarkably has a potential antitumor agent. Method: Our findings and opinions are based on a comprehensive search through scientific resources and correspondingly relating all the keywords using the Boolean technique and Medical Subject Headings (MeSH) term search to find the interest study. Review: By understanding curcumin and its target genes, curcumin itself can induce regulation of tumor suppression and oncogenic microRNA. MiR-9 has proven to be expressed for modulating the mutation genes causing tumorogenesis in ameloblastoma. Curcumin also upregulates miR-9, causing cytotoxic activity against cancers in many proven studies. Conclusion: The highly expressed miR-9 curcumin-mediated ameloblastoma inhibition will be the new insight and adjunct cancer therapy.
Mdm2 Gene as Transcriptional Protein Antagonist of P53 in OSCC with Mir-218 Expression Hanif, Hilmy Irsyadi; Zafar, Anis Fatimah; Puteri, Astari; Wati, Sisca Meida; Rahayu, Retno Pudji
Bhakta Dental Journal Vol 2 No 02 (2024): Desember
Publisher : Fakultas Kedokteran Gigi IIK Bhakti Wiyata, Kediri.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56710/bhaktadent.v2i02.47

Abstract

Background: Murine double minute-2 (Mdm-2) gene expressed overly to the various type of human cancers. Murine double minute-2 associates with p53 affecting negatively with its gene products for activation of its transcriptional function. These genes mainly expressed in oral squamous cell carcinomas with p53 mutation condition. MicroRNAs nowadays becoming a promising diagnostic and prognostic biomarkers for malignancy through the expression and regulating the transcriptional function. It is reported that mir-218 expression may indicate the occurrence of OSCC. Purpose: The literature describes the putative pathway and function of mdm2 gene as transcriptional antagonist function of p53 in OSCC of mir-218 expression. Review(s): The relationship of mdm2 with mir-218 expression in OSCC may indicate the alternative mechanism of p53 dysfunction condition. Downregulated mir-218 will tend less binding to promoter of p53 causing the mutant state. The overexpression of mdm-2 may constitute inactivation of p53. Conclusion: The study findings may suggest mdm2 protein causing in OSCC due alternative mechanism of p53 as downregulated expression of mir-218.
Co-Authors Hardiyani, Reisca Tiara Heni Susilowati Puteri, Astari Retno Pudji Rahayu Septiani, Intan Dzahabiyah Sisca Meida Wati Zafar, Anis Fatimah