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All Journal Journal Orthopaedi and Traumatology Surabaya (JOINTS) Jurnal Layanan Masyarakat (Journal of Public Service)
Mohammad Hardian Basuki
Department Of Orthopedics And Traumatology, Faculty Of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital
Humanities Decision Sciences, Operations Research & Management Environmental Science Health Professions Medicine & Pharmacology Social Sciences Other

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Growth Factor Comparison in Cortical Demineralized Bone Matrix that Demineralized Using Chloric and Acetic Acid Edward, Mouli; Mahyudin, Ferdiansyah; Basuki, Mohammad Hardian; Suroto, Heri; Perwira, Ferdiansyah Danang
Journal Orthopaedi and Traumatology Surabaya Vol. 12 No. 1 (2023): April 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v12i1.2023.1-9

Abstract

Background: Demineralized bone matrix (DBM) is an alternative biomaterial for which specific acid and immersion time are needed to optimize growth factor preservation. The optimal demineralization protocol for preserving growth factors in DBM remains unclear. This study investigated DBM extraction methods using different acids and immersion times to maintain optimal growth factor preservation.Methods: This in vitro experimental laboratory study used a randomized controlled post-test-only group design. We characterized the Insulin-like growth factor-1 (IGF-1), Bone morphogenetic protein-2 (BMP-2), and Transforming growth factor-β (TGF-β) content of 1 gram of New Zealand White Rabbit cortical bone immersed in 0.6 M hydrochloric acid and 0.5 M acetic acid for 3, 6, and 9 days. We then analyzed the differences in growth factor levels in each acid and performed statistical analysis.Results: IGF-1 levels were higher in DBM demineralized with acetic acid than with hydrochloric acid. BMP-2 and TGF-β levels were higher in DBM demineralized using hydrochloric acid. The concentration of growth factors decreased over time in DBM demineralized using acetic acid. The highest growth factor level was obtained after 6 days of immersion in hydrochloric acid.Conclusion: DBM demineralized with acetic acid yielded higher average IGF-1 levels compared to hydrochloric acid. However, BMP-2 and TGF-β levels were higher with hydrochloric acid. Growth factor levels in hydrochloric acid peaked at 6 days and then decreased. These results suggest that avoiding over-demineralization is important for maintaining growth factor levels. Further research is needed to optimize DBM processing.
ENHANCING KNOWLEDGE AND EDUCATION OF BONE CANCER FOR ADOLESCENT IN INDONESIA Abdul Bari, Yunus; Mahyudin, Ferdiansyah; Edward, Mouli; Basuki, Mohammad Hardian; Martanto, Tri Wahyu; Wardhana, Teddy Heri; Suyono, Rifki Effendi; Purnamasari, Yunita; Permana, Muhammad Dimas Arya Candra; Ardana, Fahrizal Novan
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 9 No. 1 (2025): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v9i1.2025.019-025

Abstract

Despite much-advanced therapy developed for bone cancer, prevention of the disease remains the most favorable and low-cost management approach. Bone cancer prevention and education should be initiated with adolescents.  Adolescents are the right group to receive bone cancer education, as they are in an active learning phase and have the potential to develop risky behaviors that can increase vulnerability to cancer, as they are in a stage of active learning but also face the development of risky and unhealthy behaviors. This study aims to assess the knowledge of bone cancer among adolescents in Indonesia. It is a cross-sectional study that uses a questionnaire to evaluate the participants' knowledge of bone cancer. A total of 39 questions regarding family history and general knowledge of cancer are given to the students in a pre-test and post-test format. Between the tests, a group of orthopedic specialists provided a short lecture to the students about the basic knowledge and prevention of bone cancer. The study involved 564 students from junior and senior high schools in Indonesia, with an overall mean age of 14.79 years. Bone cancer was mentioned in the family history of only 0.4% of the participants, but 21.5% to 23.5% were unsure about their own family cancer status. The study found a significant statistical result, indicating that the short lectures given by the orthopedic specialists were effective in enhancing the students' knowledge about bone cancer. The findings suggest that adolescents in Indonesia are still uncertain about their family cancer status and often misinformed about the symptoms of bone cancer. However, an educational lecture or discussion led by an expert in the field has proven to be an effective way to improve the students' knowledge about bone cancer.
Co-Authors Abdul Bari, Yunus Ardana, Fahrizal Novan Ferdiansyah Mahyudin Heri Suroto Martanto, Tri Wahyu Mouli Edward Muhammad Dimas Arya Candra Permana, Muhammad Dimas Arya Candra Perwira, Ferdiansyah Danang Suyono, Rifki Effendi Wardhana, Teddy Heri Yunita Purnamasari, Yunita