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All Journal Jurnal Biologi Tropis
Anggraeni, Baiq Annisa Ulfi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Hepatic Cirrhosis: A Literature Review Dewi, Komang Puspa; Abida, Aisya Nur; Aswandani, Alifa; Anggraeni, Baiq Annisa Ulfi; Shofa, Dhiya Atsila; Aunurrahman, Muhammad Rezky Audia; Husna, Najla Firyal
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7801

Abstract

Hepatic cirrhosis is a chronic liver disease characterized by fibrosis and regeneration of nodules in the liver, which if it occurs for a long time, hepatocyte cells will be damaged so that they cannot function again, potentially threatening life. The prevalence of incidence and mortality depends on the progression of hepatic cirrhosis, which is influenced by the patient's etiology and treatment. The purpose of writing this article is to provide new insight into the importance of understanding the risk factor and causes of hepatic cirrhosis. This study uses a literature review approach by collecting data from online databases including Google Scholar, ProQuest, MDPI, and PubMed to search for articles discussing “Hepatic Cirrhosis”. Early detection based on clinical manifestations and appropriate treatment can reduce mortality and prevent complications that may worsen the patients condition.
Antibacterial Activity of Ethyl Acetate Fraction of Centella asiatica by Soxhletation Extraction Against Pseudomonas aeruginosa Anggraeni, Baiq Annisa Ulfi; Mukhlishah, Neneng Rachmalia Izzatul; Rosyunita, Rosyunita
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8075

Abstract

Treatment of P. aeruginosa infection often involves antibiotics but these bacteria can develop resistance. An alternative strategy is developing drugs from natural ingredients such as gotu kola herb (Centella asiatica) which contains potential antibacterial secondary metabolites. This study aims to test the antibacterial activity of the ethyl acetate fraction of C. asiatica extracted by the soxhletation method against clinical isolates of P. aeruginosa and identify the secondary metabolites. The research used laboratory experiment using the disc diffusion method (Kirby-Bauer) in vitro. It includes 3 treatment groups with concentrations of 5.000 ppm, 7.500 ppm, and 10.000 ppm and 2 control groups: positive (colistin) and negative (DMSO 10%). The diameter of the inhibition zone served as an indicator of activity, and each group was reproduced five times. The biggest inhibitory zone diameter, with an average of 3 mm, was formed by the C. asiatica ethyl acetate fraction at a concentration of 7.500 ppm, according to the results. Secondary metabolites such triterpenoids, flavonoids, and phenolics were detected by phytochemical analyses. The ethyl acetate fraction of C. asiatica exhibited antibacterial activity against clinical isolate P. aeruginosa, as demonstrated by the significant difference between all concentration series with the positive control in the Mann-Whitney post-hoc test results.
Co-Authors Abida, Aisya Nur Aswandani, Alifa Aunurrahman, Muhammad Rezky Audia Dewi, Komang Puspa Husna, Najla Firyal Mukhlishah, Neneng Rachmalia Izzatul Rosyunita, Rosyunita Shofa, Dhiya Atsila