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All Journal Jurnal Biologi Tropis Promotor: Jurnal Mahasiswa Kesehatan Masyarakat
Syalsabila, Dara Pitra
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health Other

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Management and Complications of Cerebral Malaria Putra, Rifky Sandya Rakadi; Retnaningsih, Ekawaty; Kadarisma, Shofia; Sesariana, Mayumi Agestia; Syalsabila, Dara Pitra; Karlina, Fairuz
PROMOTOR Vol. 8 No. 4 (2025): AGUSTUS
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v8i4.1287

Abstract

Malaria remains a major public health issue in Indonesia, particularly in regions with high endemicity such as Papua and East Nusa Tenggara. According to the 2010 Basic Health Research (Riskesdas), the national malaria prevalence was 0.6%, with the highest rates recorded in West Papua (10.6%), Papua (10.1%), and East Nusa Tenggara (4.4%). In 2023, Papua continued to be identified as a region with high endemicity, while West Nusa Tenggara was classified as having low endemicity. Severe malaria, including cerebral malaria, is a serious complication characterized by central nervous system dysfunction, such as decline consciousness, seizures, and neurocognitive impairment, as well as systemic complications such as anemia, hypoglycemia, metabolic acidosis, and hepatosplenomegaly. Management of severe malaria requires the administration of antimalarial injections, such as intravenous artesunate as the first line therapy or quinine drip if artesunate is unavailable, performed in healthcare facilities equipped with inpatient care and intensive monitoring. This procedure involves close monitoring of blood pressure, temperature, blood glucose levels, and organ function to prevent further complications. The prognosis of cerebral malaria patients depends on the timeliness of diagnosis and proper management, while comprehensive care can improve recovery rates and reduce long-term risks. Preventive efforts through strengthening healthcare facilities in endemic areas and increasing public awareness is crucial to reduce the incidence of severe malaria and its adverse effects.
Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review Syalsabila, Dara Pitra; Manafe, Carolina Janicca Winda
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7950

Abstract

This article reviews the potential of combining Epigallocatechin-3-Gallate (EGCG) from green tea and 5-Fluorouracil (5-Fu) to enhance the effectiveness of colorectal cancer therapy. Colorectal cancer is a common type of cancer with a high mortality rate, particularly due to resistance to standard therapies like 5-Fu. The article aims to explore the potential of EGCG as a combination therapy to overcome resistance and reduce the side effects of chemotherapy. The method used is a narrative literature review, collecting studies from PubMed, google scholar and proquest databases. The review findings show that EGCG can induce apoptosis, inhibit cancer cell growth, and increase cell sensitivity to 5-Fu. The combination of EGCG and 5-Fu has proven effective in suppressing cancer cell proliferation and reducing resistance to 5-Fu, especially in drug-resistant colorectal cancer cells. In conclusion, the EGCG and 5-Fu combination has the potential to become a more effective and safer colorectal cancer therapy with a lower risk of side effects, offering a promising prospect for future cancer therapy development.
Co-Authors Kadarisma, Shofia Karlina, Fairuz Manafe, Carolina Janicca Winda Putra, Rifky Sandya Rakadi Retnaningsih, Ekawaty Sesariana, Mayumi Agestia