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All Journal Jurnal Biologi Tropis Promotor: Jurnal Mahasiswa Kesehatan Masyarakat
Retnaningsih, Ekawaty
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Nursing Public Health Other

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Management and Complications of Cerebral Malaria Putra, Rifky Sandya Rakadi; Retnaningsih, Ekawaty; Kadarisma, Shofia; Sesariana, Mayumi Agestia; Syalsabila, Dara Pitra; Karlina, Fairuz
PROMOTOR Vol. 8 No. 4 (2025): AGUSTUS
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v8i4.1287

Abstract

Malaria remains a major public health issue in Indonesia, particularly in regions with high endemicity such as Papua and East Nusa Tenggara. According to the 2010 Basic Health Research (Riskesdas), the national malaria prevalence was 0.6%, with the highest rates recorded in West Papua (10.6%), Papua (10.1%), and East Nusa Tenggara (4.4%). In 2023, Papua continued to be identified as a region with high endemicity, while West Nusa Tenggara was classified as having low endemicity. Severe malaria, including cerebral malaria, is a serious complication characterized by central nervous system dysfunction, such as decline consciousness, seizures, and neurocognitive impairment, as well as systemic complications such as anemia, hypoglycemia, metabolic acidosis, and hepatosplenomegaly. Management of severe malaria requires the administration of antimalarial injections, such as intravenous artesunate as the first line therapy or quinine drip if artesunate is unavailable, performed in healthcare facilities equipped with inpatient care and intensive monitoring. This procedure involves close monitoring of blood pressure, temperature, blood glucose levels, and organ function to prevent further complications. The prognosis of cerebral malaria patients depends on the timeliness of diagnosis and proper management, while comprehensive care can improve recovery rates and reduce long-term risks. Preventive efforts through strengthening healthcare facilities in endemic areas and increasing public awareness is crucial to reduce the incidence of severe malaria and its adverse effects.
Resveratrol: A Potential Active Compound for Inflammatory Bowel Disease Saraswati, Ni Wayan Citra Ayu; Nugraha, Gede Rama Hardy; Retnaningsih, Ekawaty; Afifah, Fiza; Firdaus, Silmi; Mutia, Baiq Marceliya Anjani; Mukhlishah, Neneng Rachmalia Izzatul
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7303

Abstract

Inflammatory Bowel Disease (IBD) is a chronic intestinal disorder consisting of Crohn’s Disease (CD) and Ulcerative Colitis (UC). The highest prevalence of IBD is found in Asia and the cases often occur in the 15-35 group of age. Conventional therapy options that are commonly used have some side effects that impact IBD patients. Therefore, it is necessary to look for new strategies in order to treat IBD regarding their effectiveness, affordability and achieving minimum side effects. Resveratrol, a natural non-flavonoid polyphenolic compound, is commonly found in grapes and various types of berries. It is known to potentially overcome inflammation in IBD through various mechanisms including acting as anti-inflammatory, antioxidant, immunomodulatory effects, and its ability to influence the gut microbiota. This study is aiming for explaining and reviewing further mainly on resveratrol’s extraction method and its mechanism of actions to improve IBD. The resources for this study are done by searching through PubMed, ProQuest, ScienceDirect, MDPI, and Google Scholar with keywords (Inflammatory Bowel Disease) AND (Resveratrol), ⁠(Incidence and Prevalence) of Inflammatory Bowel Disease across Asia, (Threat) AND (Therapy) AND (Inflammatory Bowel Disease), (Bioactive) AND (Therapy) AND (Inflammatory Bowel Disease), (Extraction) AND (Method) AND (Resveratrol), and (Pathophysiology) AND (Inflammatory Bowel Disease). Based on evidence found on resveratrol’s benefits, this compound is apparently promising to alternatively treat IBD, but still needs more research to support its effectiveness.
Co-Authors Afifah, Fiza Firdaus, Silmi Kadarisma, Shofia Karlina, Fairuz Mukhlishah, Neneng Rachmalia Izzatul Mutia, Baiq Marceliya Anjani Nugraha, Gede Rama Hardy Putra, Rifky Sandya Rakadi Saraswati, Ni Wayan Citra Ayu Sesariana, Mayumi Agestia Syalsabila, Dara Pitra