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Manafe, Carolina Janicca Winda
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Necrotizing Enterocolitis: Synbiotics, Probiotics, and Prebiotics Prevention Aziri, Zirly Vera; Manafe, Carolina Janicca Winda
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7490

Abstract

Necrotizing Enterocolitis (NEC) or intestinal inflammation is a gastrointestinal disease that is the leading cause of death among infants. NEC is often diagnosed late due to its non-specific signs and symptoms, resulting in increased mortality and morbidity. The purpose of this paper is to explain the mechanisms of how synbiotics, probiotics, and prebiotics contribute to the prevention of NEC. Several randomized trials and observational studies have identified various factors associated with NEC. However, the causality of many of these factors remains unclear and may involve different etiological mechanisms. Prevention of NEC can be achieved through the administration of synbiotics, probiotics, and prebiotics. According to previous research, the administration of synbiotics, probiotics, and prebiotics has significant potential and benefits in preventing NEC. The data sources were obtained by conducting an online search through library databases, including PubMed, ProQuest, ScienceDirect, MDPI, and Google Scholar. According to previous research, the administration of synbiotics, probiotics, and prebiotics has significant potential and benefits in preventing NEC. This paper summarizes the current  etiology, risk factors and synbiotics, probiotics, and prebiotics Prevention of Necrotizing Enterocolitis.
Necrotizing Enterocolitis: Stem Cell as Future Potential Therapy Syafitri, Bq. Annisa Salmaadani; Manafe, Carolina Janicca Winda; Hulfifa, Lale Nandita; Aziri, Zirly Vera; Afifah, Fiza; Wahyudi, Syahla Marsellita; Musyarof, Disa Fadil
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7529

Abstract

Necrotizing enterocolitis (NEC) is an inflammatory bowel condition in infants and considered as one of the leading causes of death in infants, especially premature infants. The high mortality rate due to NEC in recent decades has become a problem because there is no current therapy that can optimally treat NEC. Currently, NEC is treated using Bell's Staging as a guide and surgery is a common procedure, especially if necrosis has occurred. However, complications arising from surgery not only reduce the patient's quality of life but can also result in death. Therefore, it is necessary to find new therapy in order to treat NEC effectively and minimize the possibility of side effects in NEC patients. Stem cells are known for their regenerative abilities which is potential to overcome tissue damage due to excessive inflammation in NEC. Previous studies also show that stem cells have become new therapy to treat other intestinal diseases which have similar features with NEC. This study aims to explain mainly on stem cells’s promising mechanism of action in treating NEC. The method used for this study is a literature review design by selecting and reviewing relevant previous literature using databases such as Google Scholar, PubMed and Science Direct. This paper summarizes pathophysiology, clinical manifestation, current therapy and mechanism of action of stem cells and their derivatives as future potential therapy for NEC. Based on evidence found, stem cells and their derivatives are potential to be used as NEC therapy in the future. However, the data obtained is not sufficient to support its use in humans. Given the urgency in finding an effective NEC management and the potency of stem cells, further research is needed to support the use of stem cells as NEC therapy.
Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review Syalsabila, Dara Pitra; Manafe, Carolina Janicca Winda
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7950

Abstract

This article reviews the potential of combining Epigallocatechin-3-Gallate (EGCG) from green tea and 5-Fluorouracil (5-Fu) to enhance the effectiveness of colorectal cancer therapy. Colorectal cancer is a common type of cancer with a high mortality rate, particularly due to resistance to standard therapies like 5-Fu. The article aims to explore the potential of EGCG as a combination therapy to overcome resistance and reduce the side effects of chemotherapy. The method used is a narrative literature review, collecting studies from PubMed, google scholar and proquest databases. The review findings show that EGCG can induce apoptosis, inhibit cancer cell growth, and increase cell sensitivity to 5-Fu. The combination of EGCG and 5-Fu has proven effective in suppressing cancer cell proliferation and reducing resistance to 5-Fu, especially in drug-resistant colorectal cancer cells. In conclusion, the EGCG and 5-Fu combination has the potential to become a more effective and safer colorectal cancer therapy with a lower risk of side effects, offering a promising prospect for future cancer therapy development.
Co-Authors Afifah, Fiza Aziri, Zirly Vera Hulfifa, Lale Nandita Musyarof, Disa Fadil Syafitri, Bq. Annisa Salmaadani Syalsabila, Dara Pitra Wahyudi, Syahla Marsellita