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All Journal Jurnal Biologi Tropis
Linda Silvana Sari
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Effect of Formaldeyde Induction of Histopathological Features of The Lungs of Wistar Rats (Rattus Norvegicus) Yassa, I Wayan Radityakara Wirasena; Anak Agung Ayu Niti Wedayani; Restuningdyah, Novia Andansari Putri; Linda Silvana Sari; Eka Arie Yuliyani
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8173

Abstract

Formaldehyde, a known carcinogen prevalent in everyday environments, poses significant health risks, particularly through inhalation exposure. This study investigates the histopathological changes in the lungs of Wistar rats induced by formaldehyde at doses of 20, 30, and 40 parts per million (ppm) over a three-month period. The research aims to elucidate the onset of dysplasia, a cellular defense mechanism characterized by abnormal epithelial proliferation, as a response to carcinogenic exposure. Utilizing a post-test only control group experimental design, we observed that increased formaldehyde exposure correlates with a heightened severity of dysplasia, with a statistically significant result (p = 0.002). Our findings indicate that varying doses of formaldehyde lead to differential degrees of dysplasia, underscoring the importance of dose-response relationships in assessing the carcinogenic effects of formaldehyde on lung tissue.
Co-Authors Anak Agung Ayu Niti Wedayani Eka Arie Yuliyani Restuningdyah, Novia Andansari Putri Yassa, I Wayan Radityakara Wirasena