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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Yassa, I Wayan Radityakara Wirasena
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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PROTECTIVE ROLE OF HUMAN BREAST MILK AGAINST NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS Putri, Dyah Arista; Patandianan, Firdaus Kamma; Latifa, Nindy Citra; Ramadhania, Yasmin Najla; Rofilah, Alita Khainur; Maharani, Baiq Syarifaturrayyan; Yassa, I Wayan Radityakara Wirasena; Arigi, Lalu Ahmad Gamal
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17753

Abstract

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disease that predominantly affects preterm infants, with high rates of morbidity and mortality. Human breast milk (HBM) has long been recognized as the most effective nutritional intervention for preventing NEC due to its unique bioactive components such as immunoglobulins, lactoferrin, glutamine, vitamins, and human milk oligosaccharides (HMOs), which act through mechanisms including strengthening the intestinal barrier, modulating immune responses, and regulating the gut microbiota. This narrative review aims to synthesize recent evidence on the protective role of HBM against NEC, with particular emphasis on the function of HMOs, probiotics, and complementary nutritional interventions designed to replicate or enhance HBM’s bioactivity. The methods applied in this review followed a narrative literature search in PubMed, Scopus, and Google Scholar for studies published between 2015 and 2025 on the effects of breastfeeding on NEC risk in preterm infants, using predefined eligibility criteria. The findings indicate that HBM significantly reduces NEC incidence, while supplemental interventions such as prebiotics and probiotics may serve as complementary strategies, particularly when the availability of mother’s own milk is limited. Overall, HBM remains the primary protective factor against NEC, and optimizing its provision in neonatal care is critical for improving outcomes among preterm infants.
Effect of Formaldeyde Induction of Histopathological Features of The Lungs of Wistar Rats (Rattus Norvegicus) Yassa, I Wayan Radityakara Wirasena; Anak Agung Ayu Niti Wedayani; Restuningdyah, Novia Andansari Putri; Linda Silvana Sari; Eka Arie Yuliyani
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8173

Abstract

Formaldehyde, a known carcinogen prevalent in everyday environments, poses significant health risks, particularly through inhalation exposure. This study investigates the histopathological changes in the lungs of Wistar rats induced by formaldehyde at doses of 20, 30, and 40 parts per million (ppm) over a three-month period. The research aims to elucidate the onset of dysplasia, a cellular defense mechanism characterized by abnormal epithelial proliferation, as a response to carcinogenic exposure. Utilizing a post-test only control group experimental design, we observed that increased formaldehyde exposure correlates with a heightened severity of dysplasia, with a statistically significant result (p = 0.002). Our findings indicate that varying doses of formaldehyde lead to differential degrees of dysplasia, underscoring the importance of dose-response relationships in assessing the carcinogenic effects of formaldehyde on lung tissue.
Co-Authors Anak Agung Ayu Niti Wedayani Arigi, Lalu Ahmad Gamal Eka Arie Yuliyani Latifa, Nindy Citra Linda Silvana Sari Maharani, Baiq Syarifaturrayyan Patandianan, Firdaus Kamma Putri, Dyah Arista Ramadhania, Yasmin Najla Restuningdyah, Novia Andansari Putri Rofilah, Alita Khainur