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All Journal Jurnal Biologi Tropis Jurnal Abdi Insani
Rohmaniah, Salis Alyatur
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Toxicity and Apoptosis Test of 96% Ethanol Extract of Agelas Cavernosa on Vero Cells Mahbub, Khafid; Rusmalina, Siska; Indriono, Anik; Mahfur, Mahfur; Julian, Rixzal Azis; Maulidya, Dina Achada; Dika, Ika Vina; Rohmaniah, Salis Alyatur
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8262

Abstract

Agelas cavernosa sponge is a sponge from the Demospongiae class which includes 90% of all types of sponges. Agelas cavernosa sponge is known to have antibacterial activity. Research data on the toxicity and apoptosis test of Agelas cavernosa sponge on vero cells as far as researchers know has not been tested. The purpose of this study was to determine the toxicity and apoptosis of Agelas cavernosa ethanol extract. The research method was carried out using the MTT Assay method for toxicity testing and the flowsitometry method for apoptosis testing. Alkaloids, flavonoids, saponins, terpenoids, and polyphenols were all detected in the Agelas cavernosa ethanol extract, according to the results of phytochemical screening. The apoptosis test yielded vero cell viability of 82.2%, whereas the toxicity test yielded an LC50 value for vero cells of 197.84 ppm.
OBAT TRADISIONAL SEBAGAI ADJUVAN UNTUK MENINGKATKAN KUALITAS HIDUP DAN PRODUKTIVITAS WARGA DESA KARANGANYAR PENDERITA DIABETES MELITUS Mahfur, Mahfur; Khasanah, Nunung; Nahdliyyah, Ade Irma; Arni, Aneke Desvita; Rohmaniah, Salis Alyatur
Jurnal Abdi Insani Vol 12 No 11 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i11.3153

Abstract

Karanganyar Village, Batang District, has great potential for utilizing traditional medicinal plants to improve community health. Cases of diabetes mellitus in the area have increased due to unhealthy lifestyles and excessive sugar consumption. Local plants such as bay leaves (Syzygium polyanthum), bitter leaf (Andrographis paniculata), cinnamon (Cinnamomum verum), and turmeric (Curcuma xanthorrhiza) possess proven antihyperglycemic effects and are safe for use as adjuvant therapy. This community service program aimed to educate and empower the community to independently utilize local resources. The activity, held at the Karanganyar Village Hall with 30 PKK women participants, employed pre-tests, material presentations, interactive discussions, and post-tests to assess knowledge improvement. Results showed that participants initially lacked understanding of adjuvant concepts and medicinal plant utilization. However, after the sessions, all participants demonstrated significantly better comprehension and confidence in applying traditional medicine to support diabetes management. The high engagement level indicated that the materials were relevant and beneficial to the community’s needs. This program effectively enhanced public knowledge of traditional medicine as an adjuvant for diabetes mellitus and has the potential for independent application in local health practices.  
Co-Authors Ade Irma Nahdliyyah Anik Indriono Arni, Aneke Desvita Dika, Ika Vina Julian, Rixzal Azis Khasanah, Nunung mahbub, khafid Mahfur, Mahfur Maulidya, Dina Achada Siska Rusmalina