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Dika, Ika Vina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Anti-Inflammatory Activity Assay of Ethanol Extract of Agelas cavernosa Sponge using Protein Denaturation Method Walid, Muhammad; Nila Oktaviani; Julian, Rixzal Aziz; Rohmah, Salis Alyatur; Achada, Dina; Dika, Ika Vina; Mahfur, Mahfur
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7661

Abstract

Inflammation is a tissue response to cell damage, and alternative medicine is needed to treat this like a sponge. Indonesia is a country that has a lot of biodiversity originating from the sea. Agelas cavernosa is a sponge of the Demospongiae class, this class is the largest class that includes 90% of all types of sponges. Agelas Cavernosa sponge is known to contain triterpenoids and has antibacterial activity. Data on research on the activity of Agelas cavernosa sponge as an anti-inflammatory as far as researchers know has not been carried out. The aim of this study was to determine the anti-inflammatory activity of the ethanol extract of the Agelas cavernosa sponge. The research method was carried out using the protein denaturation method. The Agelas cavernosa sponge extracted with etanol 96%. The assay of anti-inflammatory with protein denaturation using spectrophotometry at wavelengths 660 nm. The results showed that the inhibition ability of 20% protein denaturation of ethanol extract of Agelas cavernosa was obtained at a concentration of 150 ppm. The results of the study showed that the IC50 of the ethanol extract obtained was 455.96 pppm, significantly different from the positive control of sodium diclofenac, which was 36.51 ppm. Based on the data obtained from the research results, it shows that the ethanol extract of Agelas cavernosa sponge does not have the potential as an anti-inflammatory.
Toxicity and Apoptosis Test of 96% Ethanol Extract of Agelas Cavernosa on Vero Cells Mahbub, Khafid; Rusmalina, Siska; Indriono, Anik; Mahfur, Mahfur; Julian, Rixzal Azis; Maulidya, Dina Achada; Dika, Ika Vina; Rohmaniah, Salis Alyatur
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8262

Abstract

Agelas cavernosa sponge is a sponge from the Demospongiae class which includes 90% of all types of sponges. Agelas cavernosa sponge is known to have antibacterial activity. Research data on the toxicity and apoptosis test of Agelas cavernosa sponge on vero cells as far as researchers know has not been tested. The purpose of this study was to determine the toxicity and apoptosis of Agelas cavernosa ethanol extract. The research method was carried out using the MTT Assay method for toxicity testing and the flowsitometry method for apoptosis testing. Alkaloids, flavonoids, saponins, terpenoids, and polyphenols were all detected in the Agelas cavernosa ethanol extract, according to the results of phytochemical screening. The apoptosis test yielded vero cell viability of 82.2%, whereas the toxicity test yielded an LC50 value for vero cells of 197.84 ppm.
Co-Authors Achada, Dina Anik Indriono Julian, Rixzal Azis Julian, Rixzal Aziz mahbub, khafid Mahfur, Mahfur Maulidya, Dina Achada Muhammad Walid Nila Oktaviani Rohmah, Salis Alyatur Rohmaniah, Salis Alyatur Siska Rusmalina