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All Journal EDUNursing Borobudur Nursing Review Innovation in Health for Society Calvaria Medical Journal
Wardhani, Mira Kusuma
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Impact of Mozart music exposure on neuronal apoptosis in newborn Rattus norvegicus: a comparative study between light and dark conditions Maulana, Eka Nasrur; Wardhani, Mira Kusuma
Innovation in Health for Society Vol 5 No 1 (2025): January - June
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ihs.12884

Abstract

Emerging evidence suggests that Mozart music can positively impact neurodevelopment, but whether the timing of exposure during light or dark periods affects its efficacy remains unexplored. This experimental study aimed to identify the optimal timing for Mozart music exposure—either 1 hour during the dark or 1 hour during the light period—starting from the 10th day of gestation in Rattus norvegicus, and its effect on neuronal apoptosis in newborn brain cells. Using a randomized post-test only control group design, Rattus norvegicus was employed as the model for Mozart music stimulation. A total of 24 pregnant rats were randomly divided into three groups: a control group (no music exposure), treatment group 1 (1 hour of Mozart music during the dark period), and treatment group 2 (1 hour of Mozart music during the light period), with 8 mother rats per group. After birth, the two heaviest female pups from each litter were selected, resulting in 15 pups per group. These pups were sacrificed, and their brain tissues were analyzed using the TUNEL assay under 1000x magnification to determine the neuronal apoptosis index. The study reported no miscarriages or maternal deaths across all groups. The mean apoptosis index was significantly lower in treatment group 1 (24.87 ± 3.45) and treatment group 2 (23.82 ± 3.89) compared to the control group (55.98 ± 4.12) (p = 0.002 and p = 0.009, respectively). However, no significant difference was observed between treatment group 1 and treatment group 2 (p = 0.836). The findings suggest that exposure to Mozart music significantly reduces neuronal apoptosis in the brains of newborn Rattus norvegicus, regardless of whether it is played during light or dark periods. This indicates that Mozart music can be utilized flexibly, offering potential implications for neurodevelopmental interventions. Keywords: Biomedical innovation, brain cells, fundamental study, Mozart music, neurodevelopment
Duration of diabetes, glycemic control, and risk of neuropathy among diabetes population in Indonesia Al Aska, Andra Agnez; Wardhani, Mira Kusuma
Innovation in Health for Society Vol 5 No 2 (2025): July - December
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ihs.13073

Abstract

Diabetic neuropathy is a serious and common complication for individuals with Type 2 Diabetes (T2D). However, there's a scarcity of studies investigating how the duration of diabetes and glycemic control impact the development of neuropathy. This study aimed to examine the effect of diabetes duration and blood glucose levels on the risk of neuropathy in patients with T2D in Surabaya. This was an observational study utilizing a cross-sectional data collection method. Data were gathered from 150 patients between May and July 2023. Patients were categorized based on their diabetes duration (less than 5 years, 5–10 years, and greater than 10 years) and their blood glucose levels (HbA1c less than 7%, 7–10%, and greater than 10%). Neuropathy was assessed using the 10g monofilament test and the Neuropathy Disability Score (NDS). Statistical analysis involved descriptive statistics and logistic regression, with a significance level set at 0.05 for hypothesis testing. The results revealed a significantly higher risk of neuropathy in patients with T2D for more than 10 years (90%) compared to those with T2D for less than 5 years (40%). Similarly, patients with poor blood glucose control (HbA1c greater than 10%) had an 85% chance of developing neuropathy. Whereas only 30% of those with well-controlled blood glucose (HbA1c less than 7%) developed the condition. Logistic regression analysis further confirmed that both a longer diabetes duration and elevated blood glucose levels significantly increase the risk of neuropathy (p<0.05). These findings underscore the critical importance of effective blood glucose management and early neuropathy detection to prevent severe diabetic complications. Furthermore, this study highlights the urgent need for enhanced diabetes education, early screening programs, and improved healthcare strategies across Indonesia to mitigate the burden of diabetic neuropathy. Keywords: Duration of diabetes, endocrinology, glycemic control, innovation in health, type 2 diabetes
Dampak terapeutik Peperomia Pellucida terhadap kerusakan histologis ginjal akibat paparan asap rokok pada tikus Wardhani, Mira Kusuma; Idrus, Muhamad Firmansyah
Borobudur Nursing Review Vol 5 No 1 (2025): Borobudur Nursing Review Vol 5 No 1 (January-June 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bnur.13556

Abstract

Chronic Kidney Disease (CKD) is a growing health problem in many countries. One of the main causes of CKD is cigarette smoke, which contains harmful chemicals like cadmium and nicotine. These substances can damage kidney tissue and increase the risk of kidney failure. Peperomia pellucida, a small herbal plant commonly found in tropical countries, has antioxidant and anti-inflammatory properties. It has been used in traditional medicine to treat various illnesses, including kidney problems. This study aimed to find out if Peperomia pellucida extract could help heal kidney damage caused by cigarette smoke. Twenty male rats were divided into three groups: a control group, a smoke-exposed group without treatment, and a smoke-exposed group treated with Peperomia pellucida extract. The rats were exposed to cigarette smoke for four weeks. Then, the treated group received the plant extract for another four weeks. The results showed that rats treated with the extract had less damage in their kidney tissues. The improvement was measured using the EGTI scoring method (Endothelial, Glomerular, Tubular, and Interstitial). This suggests that Peperomia pellucida may be useful as a natural and affordable treatment to protect the kidneys from damage caused by cigarette smoke, especially for people exposed to secondhand smoke
Tingkat Pengetahuan dan Kesadaran Masyarakat Akan Deteksi Kanker Serviks di Lingkungan RW 12 Pondok Wage Indah 2 Sidoarjo Hernanda, Pratika; Wardhani, Mira Kusuma; Rahmawati, Febtarini; Agusaputra, Harman
Calvaria Medical Journal Vol 1 No 2 (2023): Edisi Desember 2023
Publisher : Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/cmj.v1i2.22

Abstract

Introduction: Cervical cancer is a malignant tumor that attacks the surface layer of the cervix, called squamous epithelial cells, which are located between the uterus and the vagina. It is important for women to know what factors can cause cervical cancer and have knowledge about preventing cervical cancer because the incidence of cervical cancer is still high in Indonesia, and there are still many women who lack knowledge. Method: A descriptive research design with a sample size of 33 people used total sampling of respondents who underwent pap smear examinations during Early Detection of Cervical Cancer event in RW 12 - Pondok Wage Indah 2 Sidoarjo. The data will be analyzed with a quantity test using SPSS software. Results: This research shows that the average age of respondents iss 48 years, as many as 47.2% of respondents have high education (minimum D3), the majority are housewives (IRT) as many as 25 people (69.4%), and the majority 23 people (63.9%) had good knowledge of cervical cancer risk factors, 9 people (25%) had sufficient/moderate knowledge and 1 person (2.8%) had poor knowledge. Conclusion: Respondents who underwent pap smear examinations mostly had a good level of knowledge about cervical cancer.
CONTRIBUTING FACTORS AND INTERVENTION EFFORTS FOR DIABETES MELLITUS AMONG ADOLESCENTS: A LITERATURE REVIEW Wardhani, Mira Kusuma
Jurnal EDUNursing Vol 9 No 1 (2025): April - Agustus 2025
Publisher : Universitas Pesantren Tinggi Darul Ulum

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26594/edunursing.v9i1.5662

Abstract

The rising prevalence of Type 2 Diabetes Mellitus (T2DM) among adolescents has become a significant global public health concern, including in Indonesia. This literature review aims to explore the key contributing factors and effective countermeasures in addressing adolescent diabetes. Drawing upon 35 peer-reviewed studies published between 2018 and 2024, the review identifies obesity, physical inactivity, unhealthy dietary habits, and genetic predisposition as the most prominent risk factors. Additionally, emerging contributors such as psychosocial stress and sleep disturbances are gaining attention in recent studies. The review also examines various preventive and control efforts, including school-based health programs, family involvement, digital health interventions, and national policies such as GERMAS. While many intervention strategies show promise, implementation gaps and lack of culturally adapted models remain challenges, particularly in low- and middle-income countries. Compared to previous studies, this review highlights a shift toward more holistic and biopsychosocial approaches to T2DM prevention in youth. It concludes that multifaceted interventions tailored to adolescents' specific sociocultural contexts are essential for effective and sustainable outcomes. Further research is needed to expand local evidence and evaluate long-term impacts of ongoing health programs.
Co-Authors Andra Agnez Al Aska Febtarini Rahmawati HARMAN AGUSAPUTRA Hernanda, Pratika Idrus, Muhamad Firmansyah Maulana, Eka Nasrur