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All Journal Journal of Tropical Biodiversity Riset Informasi Kesehatan
Fahira, Adinda Putri Awalia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The effectiveness of sickle cell anemia treatment using CRISPR Fahira, Adinda Putri Awalia; Widowati, Retno; Fajri, Hidayatul
Riset Informasi Kesehatan Vol 14 No 1 (2025): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v14i1.879

Abstract

The rapid advancement of medical biotechnology plays a crucial role in healthcare practices, particularly in genetic engineering for sickle cell anemia. Currently, there is no definitive cure for sickle cell anemia, but in recent years, gene therapy has been extensively researched as an alternative solution. Gene therapy trials on sickle cell anemia patients have been conducted using CRISPR technology, and its effectiveness is still under investigation. The principle involves manipulating the abnormal hemoglobin gene in erythrocytes, which causes sickle cell disease, by extracting stem cells from the patient’s bone marrow and replacing the faulty gene with a normal one using CRISPR (Clustered Regulatory Interspaced Short Palindromic Repeats). The critical components required are Cas9, an endonuclease restriction enzyme, and gRNA, which guides Cas9 to the target gene for manipulation. Once the target gene is successfully cut by Cas9, DNA polymerase naturally initiates a gene repair mechanism through the HDR (Homologue-directed repair) pathway, a process of repairing damaged DNA sequences in CRISPR. Based on tests conducted on 44 patients, 28 patients showed promising results, with their bone marrow producing functional, normal erythrocytes.
Exploration of Bird Diversity Potential for Birdwatching Ecotourism in Bangbayang Village, Sumedang, West Java Ramadani, Annisa; Assalam, Muhammad Hudan; Putra, Indeka Dharma; Agustin, Dini; Fahira, Adinda Putri Awalia; Friscila, Sulastri; Qotrunnada, Ananda
Journal of Tropical Biodiversity Vol 5 No 1 (2024): December 2024
Publisher : Universitas Nasional Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59689/bio.v5i1.244

Abstract

Sumedang was one of the districts in West Java Province that consisted of 26 sub-districts, 7 neighborhoods, and 270 villages. Bangbayang Village, located in the Situraja neighborhood, was one of the villages with ecotourism potential that had not been fully developed. The topography of the village, characterized by hills, had its own charm, and its biodiversity had not been widely explored. One aspect of this biodiversity that had potential for ecotourism was the diversity of bird species found there. Therefore, the research aimed to explore the potential and diversity of birds in Bangbayang Village, Sumedang, in the context of developing birdwatching science and ecotourism. The research was conducted in January 2023. Birds were observed using the point count method, and the data were analyzed for conservation status, the Shannon-Wiener species diversity index, the Margalef richness index, bird species evenness, and the Simpson dominance index. The results identified 35 species of birds from 20 families, 12 of which were endemic to Indonesia. Among them, two species were classified as NT (Near Threatened), two as EN (Endangered), six were included in the CITES Appendix II category, and eight species were protected under Ministerial Regulation P.106 of 2018. The diversity index, species richness index, and evenness index values were high, recorded at 3.343, 7.575, and 0.940, respectively, while no bird species dominated, with a dominance index value of 0.043. Based on their status, nine species were identified as having potential for ecotourism attraction: the black eagle, javan hawk-eagle, crested serpent-eagle, oriental honey-buzzard, flame-fronted barbet, black-banded barbet, bar-winged prinia, black-thighed falconet, and java sparrow.
Co-Authors AGUSTIN, DINI Assalam, Muhammad Hudan Friscila, Sulastri Hidayatul Fajri Putra, Indeka Dharma Qotrunnada, Ananda Ramadani, Annisa Retno Widowati