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Effectiveness and physical quality test of Ashitaba leaf extract facial wash in an effort to reduce the growth of Staphylococcus aureus Bacteria that cause acne Putri, Luluk Aniqoh Meliana; Devientasari, Chinthia
Riset Informasi Kesehatan Vol 14 No 1 (2025): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v14i1.914

Effect Test of Analgesics (Paracetamol, Ibuprofen, and Antalgin) in Local Strain Male Mice with Acetic Acid Induction Using the Writhing Test Method Chinthia Devientasaria; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 5 No. 1 (2023): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i1.88

Analgesic or pain blocking drugs are compounds that reduce or eliminate pain without causing loss of consciousness. NSAID (non-steroidal anti-inflammatory drugs) are heterogeneous compounds due to the different chemical structures of NSAID compounds, which are used to reduce mild to moderate pain, such as paracetamol, mefenamic acid, and ibuprofen. Paracetamol is used to reduce body heat caused by infection or something else. In addition, this drug also relieves pain at a mild to moderate level, this analgesic works directly on the body’s heat regulating center in the hypothalamus. The method use is writing test with acetic acid induction. The result of this study indicates that testing the effectiveness of the paracetamol, ibuprofen, and antalgin analgesic drugs in mice study showed that the analgesic power of antalgin was the best compared to paracetamol and ibuprofen.

Antibacterial Test Of Telang Flower Extract (Clitorea Ternatea L.) Against Pseudomonas Aeruginosa Luluk Aniqoh Meliana Putri; Chinthia Devientasaria
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.96

The butterfly pea flower is a shrub that can grow and live for years (perennial), can reach a height of 5 meters, has fine hair, and is woody at the base, the flower color is bright blue with a yellowish white color in the middle. Butterfly pea flower (Clitoria ternatea L.) is a plant that has long been used in medicine and has been proven to contain alkaloid and flavonoid secondary metabolite compounds which have antibacterial potential. Antibacterials are substances that can interfere with the growth or even kill bacteria by interfering with the metabolism of harmful microbes. The aim of this research was to determine the inhibitory power of telang flower simplicia extract (Clitoria ternatea L.) on the growth of Pseudomonas aeruginosa bacteria. This research aims to test the activity of butterfly pea flowers, namely by maceration using 70% ethanol solvent. For antibacterial testing using the disk diffusion method. Extracts are made in various concentrations of 10%, 20%, 30%. The positive control used was Chloramphenicol. The results of this research were that the average zone of inhibition of butterfly pea flower extract against Pseudomonas aeruginosa bacteria was 1.48 mm at 10% concentration, 2.41 mm at 20% concentration, and 5.70 mm at 30% concentration. These results show that butterfly pea flower extract has antibacterial activity against Pseudomonas aeruginosa bacteria, although the resulting inhibitory power is not strong. At a concentration of 30% butterfly pea flower extract, it has the greatest inhibitory effect on the growth of Pseudomonas aeruginosa bacteria than concentrations of 10% and 20%.

Description Of The Usage Of Antiretroviral Medicine With Atc/Ddd Method In The Primary Health Care Centers Of Kediri 2021 Dandi Fathor Rozy Pradana Saputra; Chinthia Devientasari
Strada Journal of Pharmacy Vol. 6 No. 1 (2024): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i1.109

AIDS (Acquired Immune Deficiency Syndrome) is a collection of symptoms and infections caused by damage to the human immune system, HIV (Human Immunodeficiency Virus ), a virus that can weaken human immunity. PLWHA patients must undergo antiretroviral virus (ARV) drug therapy, one of the drug use analysis classification systems is using the ATC/DDD system which is a means of researching drug use in an effort to improve the quality of drug use, one of these components is the presentation and comparison of drug consumption levels. international. The aim of this research is to determine the use of antiretroviral drug consumption in primary health care center in the Kediri City area for the 2021 period using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) method. The design of this research is quantitative descriptive, namely describing a particular event systematically and accurately and the treatment of this research is the process of collecting data and evaluating the use of antiretroviral drugs as well as verifying Primary health care center data by interviewing primary health care center pharmacists in the Kediri city area in 2021. Consumption of antiretroviral drugs (ARVs). ) is highest in the Campurejo primary health care center, namely Lamivudine (3TC) as much as 31.71%, Balowerti in primary health care center with Zidovudine (AZT) as much as 29.02% and Pesantren 1 primary health care center with the drug Nevirapine (NVP) as much as 32.62%, while the use of ARV drugs is low. At the Campurejo primary health care center, it was 0.0002% of the drug Dolutegravir (DTG), and at the Balowerti primary health care center, it was 0.0012% of the drug Dolutegravir (DTG), then at Pesantren 1 primary health care center , it was 0.0015% of the drug Dolutegravir (DTG). The incidence of HIV is still high in Indonesia, especially in the city of Kediri.

Analysis Of Compliance In Taking Anti-Tuberculosis Drug (Oat) On The Success Of Therapy In Drug-Sensitive Tuberculosis Patients At Muhammadiyah Ahmad Dahlan Hospital, Kediri City Gading Nurantika; Chintia Devientasari; Hanik Maria Dewi; Hanie Kusuma Wardani
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.146

Tuberculosis, also known as "tubercle bacilli" (TB), is a directly transmissible disease caused by the Mycobacterium tuberculosis bacteria. Tuberculosis is a leading infectious disease that causes death worldwide. The WHO also identified the importance of achieving a high level of patient compliance in TB treatment to control the spread of this disease. This study aims to measure the extent to which tuberculosis patients at Muhammadiyah Ahmad Dahlan Hospital in Kediri City adhere to their treatment, thus achieving the success of OAT (Anti-Tuberculosis Drugs) therapy. The results of this study are expected to provide insights into the relationship between medication adherence and treatment success in drug-sensitive TB patients, as well as offer recommendations for improving patient compliance in TB treatment. The design of this study is quantitative, utilizing a retrospective cohort research design. The study population consists of all pulmonary tuberculosis (TB) patients who have undergone TB treatment for six months at Muhammadiyah Ahmad Dahlan Hospital in Kediri City, totaling 42 individuals. The sample was taken using a total population sampling method. Data analysis was conducted using cross-tabulation analysis with a chi-square test. The results of the study revealed that 18 patients (43%) had high adherence, 19 patients (45%) had moderate adherence, and 5 patients (12%) had low adherence. The majority of patients, 41 individuals (98%), were cured, while 1 patient (2%) was not cured. The chi-square test results showed a p-value of 0.023<0.005. The conclusion of this study is that there is a correlation between adherence to anti-tuberculosis (OAT) medication and the success of therapy. It is recommended that the hospital pays closer attention and provides motivation for patients to continue their treatment until full recovery.

Evaluation Of Fulfillment Of Pharmacy Service Standards In Clinical Pharmacy Services For Analgesic Drugs At Wijaya Pharmacy Health Of Kediri District Titis Surya A; Fidi Setyawan; Adi Wibisono; Chinthia Devientasari
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.161

Pharmaceutical services are services related to pharmaceutical preparations such as drugs recommended for the treatment of improving the quality of life of patients. The government has made efforts to improve health services, including the construction of various health facilities such as pharmacies. In accordance with PMK Number 73 of 2016 concerning Standards of Clinical Pharmacy Services in Pharmacies, this study was conducted with the aim of determining the fulfillment of pharmaceutical service standards in clinical pharmacy services for analgesic drugs at the Wijaya Sehat Pharmacy, Kediri Regency, including clinical pharmacy services such as PIS, Counseling, DTM, and MDSE, along with the Attitudes and Behavior of pharmacists during service through patient or respondent perceptions. The research method uses a quantitative method with a cross-sectional research design, the tool used to conduct this study is a questionnaire using a Likert scale 1-4 (strongly agree, agree, disagree, strongly disagree). Sampling using accidental sampling technique of 120 respondents who purchased analgesic drugs. Instrument testing was conducted for validity and reliability in different places before conducting the study. The results obtained were that pharmaceutical services at Wijaya Sehat Pharmacy still carried out 2 services, namely PIS and Counseling, while DTM and MDSE had not been implemented due to limited human resources, there were no complaints related to Side Effects of Drugs (SED), there were no diseases that required DTM, and patients had a comfortable perception during service because pharmacists were polite and

Analysis of Salicylic Acid in Biological Fluids (Serosal) Using Uv-Vis Spectrophotometry Chintia D; Resca S.S.; Anggra I.N.A
Strada Journal of Pharmacy Vol. 6 No. 1 (2024): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i1.163

Pharmacokinetics is an aspect of pharmacology that covers the fate of drugs in the body, namely absorption, distribution, metabolism, and excretion (ADME). Overall, bioavailability shows the kinetics and comparison of the levels of active substances that reach the bloodstream to the amount of drug given. Method validation is carried out to determine that the analytical method used is accurate, specific, reproducible, and resistant to the analyte to be analyzed. An analysis model must be validated to verify that its performance parameters are sufficient to overcome the analysis problem. The research method used is included in observational experimental research. Observational experimental research is research conducted by analyzing a compound and testing it. The results of this study obtained a standard curve value of Y = 0.006x + 3.401, r2 = 0.334 with λmax 329 nm. Recovery (% recovery) in the study, the average recovery value of the concentration was 200μg/mL (118.8%); 150 μg/mL (72.1%); 100 μg/mL (131.5%). Systemic error of series concentration 200 μg/mL (-18.8%); 150 μg/mL (278%); 100 μg/mL (-31.5%). Based on the study, validation testing of the method with further precision and accuracy is needed.

Analysis of the Application WWHAM Method in Self-Medication Services to Patient Satisfaction at the Healthy Star Pharmacy in Blitar District Rohim, Abdul; Hanie Kusuma Wardani; Chinthia Devientasari; Hanik Maria Dewi
Strada Journal of Pharmacy Vol. 7 No. 2 (2025): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i2.233

Self-medication is the practice of self-medication without a doctor's prescription to treat minor complaints without a doctor's prescription. This study aims to analyse the effect of applying the WWHAM (Who, What, How Long, Action, Medication) method on patient satisfaction in self-medication services at Bintang Sehat Pharmacy in Blitar Regency. The research method used a quantitative approach with a cross-sectional design, this study involved 360 respondents. Data were collected through observations and questionnaires based on the SERVQUAL dimension, and analysed using the Spearman Rank correlation test. The results showed a significant relationship between the implementation of WWHAM and patient satisfaction (r: 0.272, p: 0.000). Tangible, responsiveness, and assurance dimensions obtained the highest level of satisfaction. The conclusion of the study is that there is a correlation between quality and satisfaction. This shows that the more complete and precise the application of the WWHAM method by pharmacists, the level of patient satisfaction with self-medication services will also increase.

Analysis of Clinical Success in HIV/AIDS Patients with First-Line Antiretroviral Therapy Devientasari, Chinthia; Putri, Luluk Aniqoh Meliana
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.108

Background: Clinical success in HIV/AIDS patients undergoing antiretroviral therapy (ART) is influenced by various factors, including treatment adherence, regular follow-up visits, and monitoring of clinical outcomes such as weight gain and the absence of opportunistic infections (OIs). Opportunistic infections are considered a key indicator of ART failure and are strongly associated with advanced disease stages and low CD4 counts. This study aimed to analyze the demographic and clinical characteristics of HIV/AIDS patients and evaluate the relationship between body weight and the incidence of opportunistic infections in patients receiving ART.Methods: This cross-sectional study used retrospective data from 95 HIV/AIDS patients collected through consecutive sampling. Data included demographic variables (gender, age, marital status, education, occupation), clinical stage (WHO), CD4 count, body weight, ART regimen, and opportunistic infections. Data were analyzed using the Chi-square test, with a p-value ≤0.05 considered statistically significant.Results: Most patients were male (52.6%) and in the productive age range of 25–46 years (74.7%). The majority were married (54.7%), had low educational attainment, and were employed (76.8%). Clinically, 88.4% were at WHO stage III, and 80% had CD4 counts <350 cells/mm³. Low body weight (<60 kg) was found in 93.7% of patients. Opportunistic infections occurred in 26.3% of patients. A statistically significant association was found between body weight and opportunistic infections (p = 0.041). However, the OR of 1.086 (95% CI: 0.479–2.464) indicated no clinically significant difference in the risk of opportunistic infections between patients with body weight <60 kg and those >60 kg.Conclusion: Although low body weight was statistically associated with opportunistic infections, it did not present a significantly increased clinical risk. Nonetheless, opportunistic infections among patients highlights the importance of early intervention, nutritional support, and timely initiation of ART to improve treatment outcomes in HIV/AIDS management.

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