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Formulasi dan Evaluasi Sediaan Gel Hand Sanitizer Ekstrak Tangkai Sirih Merah (Piper crocatum) Putra, Gilang Pratama; Amrulloh, Lalu Sanik Wahyu Fadil; Wahyuni, Ika; Wisnu, M. Ari
Medika: Jurnal Ilmiah Kesehatan Vol 4 No 2 (2024): Medika: Jurnal Ilmiah Kesehatan
Publisher : Universitas Nahdlatul Ulama Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69503/medika.v4i2.979

Abstract

Tangkai sirih merah (Piper crocatum) mengandung beberapa senyawa seperti flavonoid, alkaloid, dan tanin yang berpotensi sebagai antimikroba. Ekstrak tangkai sirih merah (Piper crocatum) dibuat dengan metode maserasi menggunakan pelarut etanol 70%. Sediaan gel diformulasikan menggunakan kombinasi bahan seperti carbopol 940, gliserin, metil paraben, dan trietanolamin. Setelah dilakukan pembuatan formulasi gel, dilanjutkan evaluasi sediaan diantaranya uji organoleptik, homogenitas, pH (keasaman), daya sebar, viskositas (kekentalan), dan daya lekat. Berdasarkan hasil penelitian diperoleh sediaan gel hand sanitizer yang stabil secara fisik. Formulasi gel yang dihasilkan memiliki viskositas yang sesuai sehingga mudah diaplikasikan, dan memberikan sensasi lembut pada kulit.
Molecular Docking: Analysis of Mahogany Plant Compounds (Swietenia macrophylla King) against the ACE2 Enzyme of SARS-CoV-2 Amrulloh, Lalu Sanik Wahyu Fadil; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32426

Abstract

Various treatment approaches have been attempted to tackle severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)  infection. One approach to develop new drugs is through the utilization of medicinal plants. Mahogany (Swietenia macrophylla King) is one of the plants that is thought to have potential as an inhibitor of SARS-CoV-2. This study aims to determine the anti-SARS-CoV-2 potential of compounds in mahogany plants that have good interactions and interaction patterns with angiotensin-converting enzime 2 (ACE2) receptors. A total of ten mahogany plant compounds were tested for drug-likeness based on Lipinski screening which will then be docked to the ACE2 molecular target, using the molecular docking method. The parameters observed were binding energy values and amino acid residues. The results of molecular docking showed that the compounds predicted to have the highest binding affinity and have similar interaction patterns with natural ligands to the ACE2 molecular target were secomahoganin and stigmasterol. The secomahoganin and stigmasterol compounds are predicted to have good interactions with the ACE2 receptor.
Uji Kualitatif Kandungan Senyawa Sianida pada Tanaman dengan Metode Pikrat Khairani, Ayudia Cipta; Ariasti, Mia; Muhsin, Lalu Busyairi; Amrulloh, Lalu Sanik Wahyu Fadil; Martayuni, Ruprika Dwi
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol 4 No 1 (2025): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v4i1.5047

Abstract

Indonesian people have traditionally utilized various local plants as alternative food sources. These plants are widely available and have considerable nutritional value; however, some of them are known to contain toxic compounds such as cyanide (HCN), which can be harmful to human health if not properly processed. Therefore, this study aimed to examine the presence of cyanide compounds in several of these commonly consumed plants. The research was conducted using a qualitative test based on the picrate method. The samples tested included cassava, cassava leaves, bamboo shoots, gadung tubers, and taro tubers. The findings indicated that all tested samples showed positive results for the presence of cyanide, as evidenced by the observed color change from yellow to reddish-brown. In conclusion, all five types of plant samples tested contained cyanide, emphasizing the importance of proper processing techniques to reduce toxicity levels before consumption by the public.