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All Journal Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Ilmiah Pharmacy ADMA: Jurnal Pengabdian dan Pemberdayaan Masyarakat Jurnal Kolaboratif Sains BIOCITY: Journal of Pharmacy Bioscience and Clinical Community Jurnal Pengabdian kepada Masyarakat IPTEKS
Ayudia Cipta Khairani
Universitas Setia Budi
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Antihyperglycemic Activity of Red Fruit Oil (Pandanus conoideus Lam) on Improving Kidney Function in STZ- NA-Induced Nephropathy Rats Ayudia Cipta Khairani; Tri Wijayanti; Gunawan Pamudji Widodo
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 2 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i22023.173-183

Abstract

Background: Type 2 diabetes mellitus can cause complications, one of which is diabetic nephropathy. Parameters that indicate damage to the kidneys are the increase in creatinine and albumin levels. One of the traditional medicines used in the treatment of DM is  red fruit (Pandanus conoideus Lam). Objective: The purpose of this study was to determine the antihyperglycemic activity and the effect of red fruit oil administration on creatinine levels, microalbumin, and renal histopathology in STZ-NA-induced rats. Methods: This study used 30 male Wistar rats conditioned with type 2 DM with STZ-NA induction. The rats have grouped into 6 groups: group I, the normal control, group II, the negative control, group III, the positive control (pioglitazone 15 mg/kg BW), and groups IV, V, and VI, the red fruit oil respectively 1.35 mL/kg BW,2.7 mL/kg BW, and 5.4 mL/kg BW. Red fruit oil is made in traditional way and prepared for 2 days. Parameters tested in the study include blood glucose levels, creatinine, microalbumin, and kidney histopathology. Data analysis used the ANOVA method followed by Tukey's post hoc test. Results: The results showed that a red fruit oil dose of 5.4 mL/kg BW was an effective dose in reducing blood glucose levels, microalbuminuria, and serum creatinine, and repairing damage to the kidneys of rats. The percent activity of a red fruit oil dose of 5.4 mL/kgBW for blood glucose levels, microalbuminuria and serum creatinine were 84.69%, 76.30%, and 92.20% respectively. Conclusion: Red fruit oil can reduce blood glucose levels, creatinine levels, microalbumin and can repair kidney damage.
Identifikasi Kandungan Senyawa Fitokimia Minyak Buah Merah (Pandanus conoideus Lam.) : Identification Of Phytochemical Compound Content of Red Fruit Oil (Pandanus conoideus Lam.) Ayudia Cipta Khairani; Nurul Indriani
Jurnal Kolaboratif Sains Vol. 7 No. 12: Desember 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v7i12.6335

Abstract

Minyak buah merah (Pandanus conoideus Lam.) memiliki kandungan fitokimia yang bermanfaat sebagai pengobatan penyakit degeneratif. Secara umum, masyarakat lokal belum mengetahui kandungan senyawa yang berperan dalam pengobatan menggunakan minyak buah merah. Kandungan fitokimia minyak buah merah dilakukan secara skrining fitokimia. Minyak buah merah didapatkan dengan cara ekstraksi secara tradisional di Papua Barat. Senyawa fitokimia yang diujikan terdiri dari flavonoid, terpenoid, steroid, dan alkaloid. Hasil pengujian menunjukkan bahwa minyak buah merah mengandung flavonoid, terpenoid, steroid, dan alkaloid.
Penyuluhan Pentingnya Cuci Tangan Yang Baik dan Benar Dalam Upaya Pencegahan Infeksi Cacing di SDN 15 Cakranegara Mia Ariasti; Lalu Busyairi Muhsin; Salsabila Yunita Kurniawan; Sri Winarni Sofya; Ayudia Cipta khaerani; Novitarini
Jurnal Pengabdian kepada Masyarakat IPTEKS Vol. 2 No. 1 (2024)
Publisher : Rajawali Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract: Worm infestation is a parasitic infection that can affect the health, nutrition, intelligence and productivity of patients, especially in primary school-aged children. The disease often occurs due to unsanitary lifestyles and poor sanitation, with a high prevalence in Indonesia, especially in West Nusa Tenggara Province. Children aged 5-14 years, especially in areas with low economic levels, are particularly vulnerable to worms due to a lack of knowledge about clean and healthy living behaviors (PHBS). One solution that can be implemented is to provide counseling to children on how to wash their hands properly to prevent worm infections. This counseling activity was conducted at SDN 15 Cakranegara using a participatory approach, in collaboration with the school and local community. The results of this activity show that counseling can increase children's understanding of the importance of washing hands with soap and running water, which is expected to prevent the spread of worm infections and other related diseases. The success of this counseling is an important step in efforts to increase health awareness among children and communities.
Evaluation of Drug Management Before and During the COVID-19 Pandemic In The Pharmaceutical Installation of NTB Provincial Hospital Wisnu, M. Ari; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32374

Abstract

The COVID-19 pandemic that occurred from 2019 to 2023 and has spread to nearly 190 countries in the world has caused a shortage of drug supply. The need for public medicines that must be available for health services makes hospitals must try to fulfill and currently, the COVID-19 pandemic situation is continuing so hospitals must be ready to provide health services to patients. This study aims to evaluate drug management in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 and during the COVID-19 pandemic in 2020. This study used a descriptive-evaluative method. The main data was collected through documents containing specific data on drug management history. Supporting data was collected through interviews with the pharmaceutical installation. The results of the suitability of drug management in the Pharmacy Installation of the NTB Provincial Hospital before the COVID-19 pandemic in 2019 obtained 5 indicators that did not meet the standards and 6 indicators that met the standards while during the COVID-19 pandemic in 2020 there were 7 indicators that did not meet the standards and 4 indicators that met the standards.
Antidiabetes Activity of Ethanol Extract of Pandan Leaves (Pandanus amaryllifolius Roxb) in Male White Mice (Mus musculus) Jehan, Nabilah Nauli; Hidayah, Harismayanti; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32378

Abstract

Diabetes Mellitus is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion. This study aims to evaluate the antidiabetic effect of ethanol extract of fragrant pandan leaves (Pandanus ammarillyfolius Roxb) on aloxane-induced male white mice (Mus musculus). After alloxane induction, all test animals reached hyperglycemic conditions with blood glucose levels of ≥126 mgdL. The method used was the Paired Sample T-Test to analyze the difference in blood glucose levels before and after the treatment. The normality of the data was tested by the Shapiro-Wilk test, while the homogeneity was tested by the Leven test. The results showed that the most effective ethanol extract of fragrant pandan leaves reduced blood glucose levels at a dose of 600mgkgBB by 26%, a dose of 400mgkgBB by 21%, a dose of 200mgkgBB by 18%, a positive control using glibenclamide 0.65mgkgBB as much as 10% and a negative control using CMC-Na by 3%.
Molecular Docking: Analysis of Mahogany Plant Compounds (Swietenia macrophylla King) against the ACE2 Enzyme of SARS-CoV-2 Amrulloh, Lalu Sanik Wahyu Fadil; Khairani, Ayudia Cipta
Journal of Islamic Pharmacy Vol 10, No 1 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i1.32426

Abstract

Various treatment approaches have been attempted to tackle severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)  infection. One approach to develop new drugs is through the utilization of medicinal plants. Mahogany (Swietenia macrophylla King) is one of the plants that is thought to have potential as an inhibitor of SARS-CoV-2. This study aims to determine the anti-SARS-CoV-2 potential of compounds in mahogany plants that have good interactions and interaction patterns with angiotensin-converting enzime 2 (ACE2) receptors. A total of ten mahogany plant compounds were tested for drug-likeness based on Lipinski screening which will then be docked to the ACE2 molecular target, using the molecular docking method. The parameters observed were binding energy values and amino acid residues. The results of molecular docking showed that the compounds predicted to have the highest binding affinity and have similar interaction patterns with natural ligands to the ACE2 molecular target were secomahoganin and stigmasterol. The secomahoganin and stigmasterol compounds are predicted to have good interactions with the ACE2 receptor.
Penyuluhan Hipertensi dan Pemeriksaan Tekanan Darah pada Warga Desa Kabul Khairani, Ayudia Cipta; Ariasti, Mia; Sofya, Sri Winarni; Muhsin, Lalu Busyairi; Anisah, Anisah
ADMA : Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 6 No. 1 (2025): ADMA: Jurnal Pengabdian dan Pemberdayaan Mayarakat
Publisher : LPPM Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/adma.v6i1.4951

Abstract

Hipertensi menjadi salah satu penyakit yang sangat banyak diderita oleh masyarakat Indonesia. Rendahnya kesadaran masyarakat akan pentingnya pemeriksaan tekanan darah rutin menjadi salah satu penyebab kejadian penyakit hipertensi terus meningkat. Perlu dilakukan upaya dalam menurunkan kasus hipertensi. Pengabdian ini bertujuan untuk memberikan penyuluhan kesehatan kepada masyarkat tentang penyakit hipertensi. Metode pengabdian ini terdiri dari 3 tahap yaitu observasi dengan melihat kondisi dan situasi lokasi pengabdian, persiapan dengan mempersiapkan bahan dan alat pengabdian, dan pelaksanaan dengan memberikan materi penyuluhan yang disertai dengan pretest dan postest serta dilakukan pemeriksaan tekanan darah. Hasil pengabdian menunjukkan bahwa kegiatan ini memberikan wawasan baru kepada peserta tentang hipertensi dan pencegahannya dilihat dari hasil pretest dan postest. Hasil pengukuran tekanan darah peserta menunjukkan bahwa 10 orang dengan tekanan darah kategori hipertensi, 3 orang kategori normal tinggi, 3 orang kategori normal, dan 9 orang kategori optimal. Penyuluhan kesehatan yang telah dilakukan berhasil meningkatkan pengetahuan peserta mengenai penyakit hipertensi dilihat dari nilai postest yang meningkat dibandingkan nilai pretest.
EFEK JUS TOMAT (Lycopersicum esculentum)TERHADAP JUMLAH ERITROSITTIKUS PUTIH (Rattus norvegicus)YANG TERPAPAR ASAP OBAT NYAMUK BAKAR Kresnapati, Bagus Aji; Afriani, Iis Rizka; Khairani, Ayudia Cipta; Ariasti, Mia; Kurniawan, Salsabila Yunita
Jurnal Ilmiah Pharmacy Vol 12, No 2 (2025)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v12i2.717

Abstract

Asap obat nyamuk bakar mengandung radikal bebas yang dapat memicu terjadinya stress oksidatif sehingga merusak sel tubuh. Radikal bebas yang berlebih di dalam tubuh dapat mempengaruhi jumlah eritrosit. Jus tomat mengandung likopen yang berperan sebagai antioksidan untuk mencegah efek negatif dari radikal bebas. Penelitian ini bertujuan untuk mengetahui efek pemberian jus tomat terhadap jumlah eritrosit tikus putih terpapar asap obat nyamuk bakar. Penelitian ini merupakan penelitian eksperimental laboratorium dengan Rancangan Acak Lengkap. Hewan uji yang digunakan pada penelitian adalah Rattus norvegicus yang dipilih secara acak dan dibagi menjadi 4 kelompok. Kelompok kontrol negatif (K-) tanpa perlakuan,  kelompok kontrol positif (K+) dipaparkan asap obat nyamuk bakar selama 8 jam/hari dan kelompok perlakuan (P1) dipaparkan asap obat nyamuk bakar selama 8 jam/hari dan jus tomat 3,76 gr/200gr BB dan kelompok perlakuan 2 (P2) dipaparkan asap obat nyamuk bakar selama 8 jam/hari dan jus tomat 7,52 gr/200gr BB. Pada hari ke-37 dilakukan pengambilan sampel darah dan dilakukan pemeriksaan jumlah eritrosit. Analisis deskriptif didapatkan nilai rataan jumlah eritrosit pada kelompok kontrol positif cenderung lebih tinggi. Hasil uji ANOVA menunjukkan adanya perbedaan signifikan antara kelompok kontrol negatif, kelompok kontrol positif dan kelompok perlakuan (p<0,05). Paparan asap obat nyamuk bakar cenderung meningkatkan jumlah eritrosit. Sedangkan pemberian jus tomat cenderung menurunkan jumlah eritrosit mendekati nilai kontrol negatif.
Uji Kualitatif Kandungan Senyawa Sianida pada Tanaman dengan Metode Pikrat Khairani, Ayudia Cipta; Ariasti, Mia; Muhsin, Lalu Busyairi; Amrulloh, Lalu Sanik Wahyu Fadil; Martayuni, Ruprika Dwi
Biocity Journal of Pharmacy Bioscience and Clinical Community Vol 4 No 1 (2025): Biocity: Journal of Pharmacy Bioscience and Clinical Community
Publisher : Department of Pharmacy, Bumigora University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/biocity.v4i1.5047

Abstract

Indonesian people have traditionally utilized various local plants as alternative food sources. These plants are widely available and have considerable nutritional value; however, some of them are known to contain toxic compounds such as cyanide (HCN), which can be harmful to human health if not properly processed. Therefore, this study aimed to examine the presence of cyanide compounds in several of these commonly consumed plants. The research was conducted using a qualitative test based on the picrate method. The samples tested included cassava, cassava leaves, bamboo shoots, gadung tubers, and taro tubers. The findings indicated that all tested samples showed positive results for the presence of cyanide, as evidenced by the observed color change from yellow to reddish-brown. In conclusion, all five types of plant samples tested contained cyanide, emphasizing the importance of proper processing techniques to reduce toxicity levels before consumption by the public.
Peningkatan pengetahuan dan kesadaran masyarakat Dusun Sape tentang hipertensi melalui edukasi dan skrining tekanan darah Ariasti, Mia; Khairani, Ayudia Cipta; Ariani, Farida; Sofya, Sri Winarni; Indriani, Nurul; Mileniaputri, Ni Putu Rainita
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 6 (2025): November (In Progress)
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i6.35291

Abstract

Abstrak Hipertensi merupakan salah satu penyakit tidak menular dengan prevalensi tinggi di Indonesia yang kerap tidak disadari oleh penderita sehingga menimbulkan risiko komplikasi serius. Upaya promotif dan preventif melalui edukasi serta deteksi dini sangat diperlukan, terutama di wilayah pedesaan. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan dan kesadaran warga Dusun Sape mengenai hipertensi melalui penyuluhan kesehatan dan skrining tekanan darah. Mitra sasaran adalah masyarakat Dusun Sape dengan jumlah peserta sebanyak 31 orang yang terdiri dari kelompok usia dewasa hingga lanjut usia. Metode pelaksanaan meliputi penyuluhan interaktif mengenai definisi, faktor risiko, pencegahan, dan komplikasi hipertensi, dilanjutkan dengan pemeriksaan tekanan darah menggunakan sphygmomanometer digital. Hasil kegiatan menunjukkan adanya peningkatan signifikan pengetahuan peserta, di mana 85% mampu menjawab benar pertanyaan pascaedukasi dibandingkan hanya 42% sebelum edukasi. Hasil skrining menemukan 28% peserta memiliki tekanan darah ≥140/90 mmHg dan dianjurkan untuk melakukan pemeriksaan lanjutan di fasilitas kesehatan. Secara kualitatif, peserta menyatakan kegiatan ini bermanfaat dalam meningkatkan pemahaman serta kesadaran pentingnya kontrol tekanan darah. Program ini memberikan dampak positif terhadap peningkatan pengetahuan dan kesadaran masyarakat mengenai hipertensi serta pentingnya deteksi dini. Diharapkan kegiatan serupa dapat dilaksanakan secara berkelanjutan guna mendukung pencegahan penyakit kardiovaskular di tingkat komunitas. Kata kunci: edukasi kesehatan; hipertensi; masyarakat desa; tekanan darah; skrining. Abstract Hypertension is one of the most prevalent non-communicable diseases in Indonesia and is often undetected, leading to serious complications if not properly managed . Preventive and promotive efforts through education and early detection are crucial, particularly in rural areas. This community service activity aimed to improve the knowledge and awareness of Sape Hamlet residents about hypertension through health education and blood pressure screening. The target group consisted of 31 participants, ranging from adults to the elderly. The method included interactive health education covering the definition, risk factors, prevention, and complications of hypertension, followed by blood pressure measurement using a digital sphygmomanometer. The results showed a significant increase in participants’ knowledge, with 85% correctly answering post-education questions compared to only 42% before the intervention. Screening findings indicated that 28% of participants had blood pressure ≥140/90 mmHg and were advised to undergo further examination at health facilities. Qualitatively, participants reported that the program was beneficial in increasing their understanding and awareness of the importance of blood pressure control. This activity had a positive impact on enhancing community knowledge and awareness regarding hypertension and the importance of early detection. Similar programs are recommended to be carried out continuously to support cardiovascular disease prevention at the community level. Keywords: hypertension; health education; screening; blood pressure; rural community.
Co-Authors Afriani, Iis Rizka Amrulloh, Lalu Sanik Wahyu Fadil Anisah Ariasti, Mia Farida Ariani Gunawan Pamudji Widodo Hidayah, Harismayanti Kresnapati, Bagus Aji Martayuni, Ruprika Dwi Mia Ariasti Mileniaputri, Ni Putu Rainita Muhsin, Lalu Busyairi Nabilah Nauli Jehan Novitarini Nurul Indriani Salsabila Yunita Kurniawan Sofya, Sri Winarni Sri Winarni Sofya Tri Wijayanti Wisnu, M. Ari