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REVIEW ARTIKEL: GEN SITOKROM YANG MEMPENGARUHI EFEKTIVITAS OBAT KONTRASEPSI DAN BERHUBUNGAN DENGAN VENOUS THROMBOEMBOLISM (VTE) Tamara, Aulia; Fibe Yulinda Cesa; Christina Agustin
JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Vol. 3 No. 1 (2025): Februari : JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL
Publisher : CV. ALIM'SPUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/jikas.v3i1.1118

Abstract

One cardiovascular condition known as venous thromboembolism (VTE) is believed to be brought on by hormonal medications like oral contraceptives. Women taking oral contraceptives are more likely to develop VTE over the age of 40 due to a genetic predisposition that can trigger the risk from the cytochrome gene. One of the genes associated with VTE and contraception is the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Methods: A quality assessment of the method and risk was conducted using The Joanna Briggs Institute (JBI) Instrument after a number of articles collected from Scopus, Crossref, Ebsco, Pubmed, Science Direct, and Google Scholar were selected by the inclusion criteria. Results:Articles or journals on the JBI instrument showed good quality in the number of 10 research particles. From the results of the journal analysis, several cytochrome genes were obtained, namely the CYP2C19, CYP3A4, CYP1A2, and CYP345 genes. Conclusion: Several types of cytochrome genes that affect oral use as well as VTE. The cytochrome CYP2C19 gene may decrease the effects of clopidogrel. The use of CYP3A4 gene-inducing drugs should be considered at the same time as contraception and it is advisable to use other drug alternatives. Concomitant use of CYP1A2 gene-inducing drugs with contraception should be avoided because they may decrease the contraceptive effect. The use of cyclosporine drugs needs to be monitored because cyclosporine can increase estrogen levels in the liver.
PERMAINAN EDUKATIF UNTUK MENINGKATKAN PENGETAHUAN TENTANG KEBERSIHAN KUKU DI TK DHARMA WANITA PERSATUAN I SUMBERSEKAR Yulinda Cesa, Fibe; Yuliati, Leny; Setya Dhini, Ellyvina; Tamara, Aulia; Cinta Sari, Yunda; B. Maharani, Novia
Jurnal Bakti untuk Negeri Vol 5 No 1 (2025): Jurnal Bakti Untuk Negeri
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/j3g2fv44

Abstract

Personal hygiene, especially nail hygiene, is a basic need that should be cultivated from an early age. Neglecting this can lead to a decline in awareness of personal hygiene and increase the risk of infectious diseases later in life. Kindergarten students, aged 4-5 years, are not fully aware of this. The methods employed include socialization; initial discussion and situational analysis; material preparation; questionnaire validity and reliability testing; socialization of the activity plan; activity implementation; monitoring and evaluation, and discussion. In this case, the educational module includes instructional materials, educational games as visual aids, and mini experiments. The counseling activity was conducted by providing instructional materials on proper handwashing followed by a mini handwashing experiment. After this activity, it continued with an educational material on nail cutting and its experiment. Based on the average student scores before and after the counseling, there was an increase in the average student score from 66 to 80 (p-value = 0.002*). Thus, this counseling has a significant impact on increasing students' knowledge and average scores.