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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Buletin Kedokteran dan Kesehatan Prima
Theresia, Yohani
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Syntax Literate: Jurnal Ilmiah Indonesia

 1 
Efek Pemberian Ekstrak Kulit Buah Mangga Arum Manis (Mangifera Indica) Terhadap Gambaran Histopatologi Tikus Wistar Jantan Obesitas Yang Diinduksi High Lipid Diet Dan Aloksan Khoven, Kimi; Theresia, Yohani; Anggraini , Tri Lidya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i9.61691

Abstract

Obesity is a global problem that can cause pancreatic damage through increased oxidative stress. Mango peel contains bioactive compounds such as flavonoids, tannins, steroids, terpenoids, alkaloids, saponins, and polyphenols that have antioxidant functions. This study aims to evaluate the effect of giving mango arum manis fruit peel extract on the histopathology of pancreatic tissue and blood sugar levels of obese male Wistar rats induced by high lipid diet and alloxan. This study used a post-test only control group design which was divided into a positive group given pioglitazone 3 mg/kg BW, a group given 30 mg/kg BW extract, 60 mg/kg BW extract, and 120 mg/kg BW sweet mango arum fruit peel extract. The results of histopathological examination of pancreatic tissue showed that in all groups there was pancreatic damage with a score of 3, so it did not show significant differences. However, in the examination of blood sugar levels, there were significant differences before and after the administration of sweet mango arum fruit peel extract, which showed the most significant results were the administration of sweet mango arum fruit peel extract at a dose of 30 mg / kg BW and 120 mg / kg BW.
Pengaruh Pemberian Ekstrak Kulit Mangga Arum Manis (Mangifera Indica) Terhadap Kadar Gula Darah Tikus Wistar Jantan Obesitas yang Diinduksi HFD (High Fat Diet) dan Aloksan Rahmadani, Oktari; Theresia, Yohani; Anggraini, Tri Lidya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62349

Abstract

Obesity is a major risk factor for type 2 diabetes mellitus characterized by insulin resistance and hyperglycemia. Sweet arum mango (Mangifera indica) peel contains bioactive compounds with potential as natural antidiabetic and antioxidant agents. This study aimed to determine the effect of sweet arum mango peel extract on blood glucose levels, body weight, and uric acid levels in obese male Wistar rats induced by HFD (high fat diet) and alloxan. An experimental study with a pretest-posttest control group design used 24 male Wistar rats divided into 4 groups: positive control (Pioglitazone 3 mg) and three treatment groups with mango peel extract at doses of 30, 60, and 120 mg/kgBW. Obesity was induced by high-fat diet administration for 21 days and alloxan 150 mg/kgBW intraperitoneally, followed by extract administration for 14 days. Data were analyzed using ANOVA and post hoc Tukey HSD tests. Phytochemical screening revealed that the extract contained alkaloids, terpenoids, saponins, and steroids. Descriptively, blood glucose levels decreased from 442.05 ± 80.80 mg/dL to 109.50 ± 21.15 mg/dL, but this was not statistically significant between groups (p=0.673). Body weight changes also showed no significant differences (p=0.947). Uric acid levels showed significant differences between treatment groups (p=0.006), with the 120 mg/kgBW dose significantly different from the 30 mg/kgBW (p=0.008) and 60 mg/kgBB doses (p=0.042). Sweet arum mango peel extract demonstrates biological potential in affecting glucose and uric acid metabolism in obese rats, although effects on blood glucose levels and body weight were not statistically significant. Further research with longer duration and optimal dosage is needed to validate the extract's effectiveness.
Co-Authors Anggraini , Tri Lidya Anggraini, Tri Lidya Atika Rimalda Nasution Binarwan Halim Citra Puan Maulidza Fadillah, Qori Khoven, Kimi Lina, Juliana Linda Chiuman Rahmadani, Oktari Reh Malem br Karo