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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Buletin Kedokteran dan Kesehatan Prima
Theresia, Yohani
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Squamous cell carcinoma of the kidney: A case report Lina, Juliana; Karo, Reh Malem br; Theresia, Yohani; Fadillah, Qori
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6544

Abstract

Primary renal squamous cell carcinoma (SCC) is a rare neoplasm strongly associated with a history of nephrolithiasis. Renal SCC is reported to have high morbidity and mortality rates, especially in the elderly population. Clinical manifestations of renal SCC are generally characterized by hematuria, flank pain, and a palpable mass in the retroperitoneal area. Histopathological examination reveals the infiltration of squamous cell nests that destroy the stroma. These cells show nuclear pleomorphism, an increased nuclear/cytoplasmic ratio, irregular nuclear membranes, coarse chromatin, prominent and dense basophilic nucleoli, and eosinophilic cytoplasm. These histopathological findings confirm the diagnosis of squamous cell carcinoma. The uniqueness of this case lies in the diagnosis of renal SCC in a relatively young age group, making it a distinct clinical concern. Further immunohistochemical examination, including CK5/6, p63, p40, and CK14 panels, is needed to determine the prognosis and appropriate treatment strategy. This case report emphasizes the importance of understanding kidney stone disease as a preventive measure against the development of renal SCC.
Efek Pemberian Ekstrak Kulit Buah Mangga Arum Manis (Mangifera Indica) Terhadap Gambaran Histopatologi Tikus Wistar Jantan Obesitas Yang Diinduksi High Lipid Diet Dan Aloksan Khoven, Kimi; Theresia, Yohani; Anggraini , Tri Lidya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i9.61691

Abstract

Obesity is a global problem that can cause pancreatic damage through increased oxidative stress. Mango peel contains bioactive compounds such as flavonoids, tannins, steroids, terpenoids, alkaloids, saponins, and polyphenols that have antioxidant functions. This study aims to evaluate the effect of giving mango arum manis fruit peel extract on the histopathology of pancreatic tissue and blood sugar levels of obese male Wistar rats induced by high lipid diet and alloxan. This study used a post-test only control group design which was divided into a positive group given pioglitazone 3 mg/kg BW, a group given 30 mg/kg BW extract, 60 mg/kg BW extract, and 120 mg/kg BW sweet mango arum fruit peel extract. The results of histopathological examination of pancreatic tissue showed that in all groups there was pancreatic damage with a score of 3, so it did not show significant differences. However, in the examination of blood sugar levels, there were significant differences before and after the administration of sweet mango arum fruit peel extract, which showed the most significant results were the administration of sweet mango arum fruit peel extract at a dose of 30 mg / kg BW and 120 mg / kg BW.
Squamous cell carcinoma of the kidney: A case report Lina, Juliana; Karo, Reh Malem br; Theresia, Yohani; Fadillah, Qori
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6544

Abstract

Primary renal squamous cell carcinoma (SCC) is a rare neoplasm strongly associated with a history of nephrolithiasis. Renal SCC is reported to have high morbidity and mortality rates, especially in the elderly population. Clinical manifestations of renal SCC are generally characterized by hematuria, flank pain, and a palpable mass in the retroperitoneal area. Histopathological examination reveals the infiltration of squamous cell nests that destroy the stroma. These cells show nuclear pleomorphism, an increased nuclear/cytoplasmic ratio, irregular nuclear membranes, coarse chromatin, prominent and dense basophilic nucleoli, and eosinophilic cytoplasm. These histopathological findings confirm the diagnosis of squamous cell carcinoma. The uniqueness of this case lies in the diagnosis of renal SCC in a relatively young age group, making it a distinct clinical concern. Further immunohistochemical examination, including CK5/6, p63, p40, and CK14 panels, is needed to determine the prognosis and appropriate treatment strategy. This case report emphasizes the importance of understanding kidney stone disease as a preventive measure against the development of renal SCC.
Pengaruh Pemberian Ekstrak Kulit Mangga Arum Manis (Mangifera Indica) Terhadap Kadar Gula Darah Tikus Wistar Jantan Obesitas yang Diinduksi HFD (High Fat Diet) dan Aloksan Rahmadani, Oktari; Theresia, Yohani; Anggraini, Tri Lidya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62349

Abstract

Obesity is a major risk factor for type 2 diabetes mellitus characterized by insulin resistance and hyperglycemia. Sweet arum mango (Mangifera indica) peel contains bioactive compounds with potential as natural antidiabetic and antioxidant agents. This study aimed to determine the effect of sweet arum mango peel extract on blood glucose levels, body weight, and uric acid levels in obese male Wistar rats induced by HFD (high fat diet) and alloxan. An experimental study with a pretest-posttest control group design used 24 male Wistar rats divided into 4 groups: positive control (Pioglitazone 3 mg) and three treatment groups with mango peel extract at doses of 30, 60, and 120 mg/kgBW. Obesity was induced by high-fat diet administration for 21 days and alloxan 150 mg/kgBW intraperitoneally, followed by extract administration for 14 days. Data were analyzed using ANOVA and post hoc Tukey HSD tests. Phytochemical screening revealed that the extract contained alkaloids, terpenoids, saponins, and steroids. Descriptively, blood glucose levels decreased from 442.05 ± 80.80 mg/dL to 109.50 ± 21.15 mg/dL, but this was not statistically significant between groups (p=0.673). Body weight changes also showed no significant differences (p=0.947). Uric acid levels showed significant differences between treatment groups (p=0.006), with the 120 mg/kgBW dose significantly different from the 30 mg/kgBW (p=0.008) and 60 mg/kgBB doses (p=0.042). Sweet arum mango peel extract demonstrates biological potential in affecting glucose and uric acid metabolism in obese rats, although effects on blood glucose levels and body weight were not statistically significant. Further research with longer duration and optimal dosage is needed to validate the extract's effectiveness.
The Effect of Andaliman Fruit Extract (Zanthoxylum acanthopodium DC) on α-Synuclein Levels in Rotenon-Induced Wistar Rats Maulidza, Citra Puan; Halim, Binarwan; Chiuman, Linda; Nasution, Atika Rimalda; Theresia, Yohani
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.10362

Abstract

Parkinson's disease is a neurodegenerative disorder characterized by loss of dopamine and formation of α-synuclein aggregates in the substantia nigra pars compacta (SNpc). This study aims to evaluate α-synuclein levels in the plasma of rotenone-induced Wistar rats as a model of Parkinson's disease and the therapeutic effect of Andaliman fruit extract. The design of this study was experimental with 25 male Wistar rats divided into five groups, negative control group (K-, only given distilled water), positive control (K+, induced rotenone 3 mg/kgBB/day for two weeks), and three treatment groups (P1, P2, P3) induced rotenone and given Andaliman extract orally at a dose of 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB respectively for 14 days. Measurement of levels was performed using ELISA on day 14 after induction and day 28 after therapy. The results of one-way ANOVA analysis showed that Andaliman extract significantly reduced α-synuclein levels at all doses compared to the positive control (p=0.000). The decrease in α-synuclein levels indicates the potential of Andaliman fruit extract in reducing Parkinson's disease-related pathology in mouse models.
Co-Authors Anggraini , Tri Lidya Anggraini, Tri Lidya Binarwan Halim Chiuman, Linda Fadillah, Qori Khoven, Kimi Lina, Juliana Maulidza, Citra Puan Nasution, Atika Rimalda Rahmadani, Oktari Reh Malem br Karo