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Squamous cell carcinoma of the kidney: A case report Lina, Juliana; Karo, Reh Malem br; Theresia, Yohani; Fadillah, Qori
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6544

Primary renal squamous cell carcinoma (SCC) is a rare neoplasm strongly associated with a history of nephrolithiasis. Renal SCC is reported to have high morbidity and mortality rates, especially in the elderly population. Clinical manifestations of renal SCC are generally characterized by hematuria, flank pain, and a palpable mass in the retroperitoneal area. Histopathological examination reveals the infiltration of squamous cell nests that destroy the stroma. These cells show nuclear pleomorphism, an increased nuclear/cytoplasmic ratio, irregular nuclear membranes, coarse chromatin, prominent and dense basophilic nucleoli, and eosinophilic cytoplasm. These histopathological findings confirm the diagnosis of squamous cell carcinoma. The uniqueness of this case lies in the diagnosis of renal SCC in a relatively young age group, making it a distinct clinical concern. Further immunohistochemical examination, including CK5/6, p63, p40, and CK14 panels, is needed to determine the prognosis and appropriate treatment strategy. This case report emphasizes the importance of understanding kidney stone disease as a preventive measure against the development of renal SCC.

Efek Pemberian Ekstrak Kulit Buah Mangga Arum Manis (Mangifera Indica) Terhadap Gambaran Histopatologi Tikus Wistar Jantan Obesitas Yang Diinduksi High Lipid Diet Dan Aloksan Khoven, Kimi; Theresia, Yohani; Anggraini , Tri Lidya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i9.61691

Obesity is a global problem that can cause pancreatic damage through increased oxidative stress. Mango peel contains bioactive compounds such as flavonoids, tannins, steroids, terpenoids, alkaloids, saponins, and polyphenols that have antioxidant functions. This study aims to evaluate the effect of giving mango arum manis fruit peel extract on the histopathology of pancreatic tissue and blood sugar levels of obese male Wistar rats induced by high lipid diet and alloxan. This study used a post-test only control group design which was divided into a positive group given pioglitazone 3 mg/kg BW, a group given 30 mg/kg BW extract, 60 mg/kg BW extract, and 120 mg/kg BW sweet mango arum fruit peel extract. The results of histopathological examination of pancreatic tissue showed that in all groups there was pancreatic damage with a score of 3, so it did not show significant differences. However, in the examination of blood sugar levels, there were significant differences before and after the administration of sweet mango arum fruit peel extract, which showed the most significant results were the administration of sweet mango arum fruit peel extract at a dose of 30 mg / kg BW and 120 mg / kg BW.

Squamous cell carcinoma of the kidney: A case report Lina, Juliana; Karo, Reh Malem br; Theresia, Yohani; Fadillah, Qori
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6544

Primary renal squamous cell carcinoma (SCC) is a rare neoplasm strongly associated with a history of nephrolithiasis. Renal SCC is reported to have high morbidity and mortality rates, especially in the elderly population. Clinical manifestations of renal SCC are generally characterized by hematuria, flank pain, and a palpable mass in the retroperitoneal area. Histopathological examination reveals the infiltration of squamous cell nests that destroy the stroma. These cells show nuclear pleomorphism, an increased nuclear/cytoplasmic ratio, irregular nuclear membranes, coarse chromatin, prominent and dense basophilic nucleoli, and eosinophilic cytoplasm. These histopathological findings confirm the diagnosis of squamous cell carcinoma. The uniqueness of this case lies in the diagnosis of renal SCC in a relatively young age group, making it a distinct clinical concern. Further immunohistochemical examination, including CK5/6, p63, p40, and CK14 panels, is needed to determine the prognosis and appropriate treatment strategy. This case report emphasizes the importance of understanding kidney stone disease as a preventive measure against the development of renal SCC.

Pengaruh Pemberian Ekstrak Kulit Mangga Arum Manis (Mangifera Indica) Terhadap Kadar Gula Darah Tikus Wistar Jantan Obesitas yang Diinduksi HFD (High Fat Diet) dan Aloksan Rahmadani, Oktari; Theresia, Yohani; Anggraini, Tri Lidya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62349

Obesity is a major risk factor for type 2 diabetes mellitus characterized by insulin resistance and hyperglycemia. Sweet arum mango (Mangifera indica) peel contains bioactive compounds with potential as natural antidiabetic and antioxidant agents. This study aimed to determine the effect of sweet arum mango peel extract on blood glucose levels, body weight, and uric acid levels in obese male Wistar rats induced by HFD (high fat diet) and alloxan. An experimental study with a pretest-posttest control group design used 24 male Wistar rats divided into 4 groups: positive control (Pioglitazone 3 mg) and three treatment groups with mango peel extract at doses of 30, 60, and 120 mg/kgBW. Obesity was induced by high-fat diet administration for 21 days and alloxan 150 mg/kgBW intraperitoneally, followed by extract administration for 14 days. Data were analyzed using ANOVA and post hoc Tukey HSD tests. Phytochemical screening revealed that the extract contained alkaloids, terpenoids, saponins, and steroids. Descriptively, blood glucose levels decreased from 442.05 ± 80.80 mg/dL to 109.50 ± 21.15 mg/dL, but this was not statistically significant between groups (p=0.673). Body weight changes also showed no significant differences (p=0.947). Uric acid levels showed significant differences between treatment groups (p=0.006), with the 120 mg/kgBW dose significantly different from the 30 mg/kgBW (p=0.008) and 60 mg/kgBB doses (p=0.042). Sweet arum mango peel extract demonstrates biological potential in affecting glucose and uric acid metabolism in obese rats, although effects on blood glucose levels and body weight were not statistically significant. Further research with longer duration and optimal dosage is needed to validate the extract's effectiveness.

The Effect of Andaliman Fruit Extract (Zanthoxylum acanthopodium DC) on α-Synuclein Levels in Rotenon-Induced Wistar Rats Citra Puan Maulidza; Binarwan Halim; Linda Chiuman; Atika Rimalda Nasution; Yohani Theresia
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.10362

Parkinson's disease is a neurodegenerative disorder characterized by loss of dopamine and formation of α-synuclein aggregates in the substantia nigra pars compacta (SNpc). This study aims to evaluate α-synuclein levels in the plasma of rotenone-induced Wistar rats as a model of Parkinson's disease and the therapeutic effect of Andaliman fruit extract. The design of this study was experimental with 25 male Wistar rats divided into five groups, negative control group (K-, only given distilled water), positive control (K+, induced rotenone 3 mg/kgBB/day for two weeks), and three treatment groups (P1, P2, P3) induced rotenone and given Andaliman extract orally at a dose of 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB respectively for 14 days. Measurement of levels was performed using ELISA on day 14 after induction and day 28 after therapy. The results of one-way ANOVA analysis showed that Andaliman extract significantly reduced α-synuclein levels at all doses compared to the positive control (p=0.000). The decrease in α-synuclein levels indicates the potential of Andaliman fruit extract in reducing Parkinson's disease-related pathology in mouse models.

The Effect of Cep-Cepan (Castanopsis costata) Leaf Extract Ointment on Post-Incision Wound Healing in Wistar Rats Yohani Theresia; Linda Chiuman; Chrismis Novalinda Ginting; Suhartomi Suhartomi
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.491-497

Wound healing remains a challenge in medical practice, as available topical medications are often expensive, less effective, or associated with side effects. This study aimed to evaluate the effect of cep-cepan (Castanopsis costata) leaf extract ointment on post-incision wound healing in Wistar rats using a post-test only control group experimental design. Cep-cepan leaf extract was obtained through maceration method using 96% ethanol, with 22% yield. This extract was then formulated into ointments with concentrations of 15%, 30%, and 45%, subsequently tested for physical stability, phytochemical content, and wound healing effectiveness. The results showed that cep-cepan leaf extract contained alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. In vivo tests on rats showed that ointments containing 30% and 45% extract significantly increased skin tensile strength and collagen density compared to the control group. The effectiveness of the 45% extract ointment was almost equivalent to gentamicin ointment as the standard group. This study indicates the potential of cep-cepan leaves as an alternative agent in wound care, providing clinical benefits at a more affordable cost and minimal side effects.

Leadership Style with Paramedic Work Motivation on General Hospital Performance Natalia Natalia; Edy Fachrial; Suandy Suandy; Yohani Theresia; I Nyoman Ehrich Lister
Proceeding of the International Conference on Health Sciences and Nursing Vol. 2 No. 1 (2025): Proceeding of the International Conference on Health Sciences and Nursing
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/ichsn.v2i1.53

This study examines the influence of leadership style and paramedic work motivation on the performance of general hospitals. The research aims to investigate how leadership approaches and motivation levels among paramedics affect hospital outcomes. Using a quantitative approach, data was collected from paramedics working in several general hospitals. The analysis included statistical methods such as regression analysis and mediation analysis to test the direct and indirect effects of leadership style and work motivation on hospital performance. The results showed that leadership style and work motivation significantly affect hospital performance. Specifically, effective leadership and high work motivation among paramedics contributed to improved hospital performance indicators. This study provides insights into how hospital management can improve performance by focusing on leadership development and motivation enhancement strategies. The findings highlight the importance of fostering a supportive leadership environment and promoting work motivation among paramedics to achieve better hospital performance.

Analisis Gangguan Visus terhadap Indeks Prestasi Kumulatif pada Mahasiswa Program Studi Sarjana Pendidikan Dokter Universitas Prima Indonesia Gunawan, Louisa Princes; Nasution, Ali Napiah; Theresia, Yohani
Empiricism Journal Vol. 7 No. 3: September 2026
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/ej.v7i3.6844

Gangguan visus sering ditemukan pada mahasiswa yang menjalani aktivitas visual jarak dekat secara intensif dan diperkirakan dapat memengaruhi proses belajar. Penelitian ini bertujuan menganalisis perbedaan Indeks Prestasi Kumulatif (IPK) menurut kategori gangguan visus pada mahasiswa Program Studi Sarjana Pendidikan Dokter Universitas Prima Indonesia. Penelitian observasional analitik dengan rancangan cross sectional dilaksanakan pada Mei 2026. Analisis mencakup 100 mahasiswa angkatan 2023 yang memenuhi kriteria penelitian. Ketajaman penglihatan diperiksa secara monokuler menggunakan Snellen chart pada jarak 6 m. Responden dengan visus kurang dari 6/6 menjalani refraksi subjektif menggunakan trial lens, sedangkan IPK diperoleh dari data akademik. Distribusi IPK tidak normal sehingga perbedaan antarkategori visus dianalisis menggunakan uji Kruskal-Wallis. Sebanyak 74 responden (74,0%) berjenis kelamin perempuan. Kategori visus terdiri atas normal pada 33 mahasiswa (33,0%), gangguan ringan pada 43 mahasiswa (43,0%), sedang pada 21 mahasiswa (21,0%), dan tinggi pada 3 mahasiswa (3,0%). Rerata IPK adalah 3,2281 ± 0,34022 dengan rentang 1,73-4,00; sebanyak 16,0% responden memiliki IPK tinggi, 73,0% sedang, dan 11,0% rendah. Nilai mean rank IPK berturut-turut ialah 43,08 pada kelompok normal, 56,30 pada gangguan ringan, 53,90 pada gangguan sedang, dan 25,17 pada gangguan tinggi. Uji Kruskal-Wallis menghasilkan H=6,574; df=3; p=0,087. Tidak terdapat perbedaan IPK yang bermakna secara statistik menurut kategori gangguan visus. Penggunaan koreksi penglihatan dan faktor akademik maupun psikososial yang tidak diukur dapat memengaruhi hasil penelitian. Analysis of the Impact of Visual Impairment on the Grade Point Average of Undergraduate Medical Students at Universitas Prima Indonesia Abstract Visual impairment is common among students who perform intensive near-vision activities and may interfere with learning. This study examined whether cumulative grade point average (GPA) differed across visual-impairment categories among undergraduate medical students at Universitas Prima Indonesia. An analytical cross-sectional study was conducted in May 2026 and included 100 students from the 2023 cohort who met the eligibility criteria. Monocular distance visual acuity was assessed with a Snellen chart at 6 m. Students whose visual acuity was worse than 6/6 underwent subjective refraction with trial lenses, and GPA was obtained from academic records. Because GPA was not normally distributed, differences across visual categories were tested with the Kruskal-Wallis test. Seventy-four participants (74.0%) were women. Visual status was classified as normal in 33 students (33.0%), mild impairment in 43 (43.0%), moderate impairment in 21 (21.0%), and high impairment in 3 (3.0%). Mean GPA was 3.2281 ± 0.34022 (range, 1.73-4.00); 16.0% of students had a high GPA, 73.0% a moderate GPA, and 11.0% a low GPA. GPA mean ranks were 43.08, 56.30, 53.90, and 25.17 in the normal, mild, moderate, and high visual-impairment groups, respectively. The Kruskal-Wallis test yielded H=6.574, df=3, and p=.087. GPA did not differ significantly across visual-impairment categories. Vision correction and unmeasured academic or psychosocial factors may have influenced the observed association.

Comparison Of The 2D:4D Ratio Between Male And Female Students At Methodist Antiochia Pancurbatu Junior High School Sinaga, Angel Grace Kesya br; Anggraini, Tri Lidya; Theresia, Yohani
Public Health Journal Vol. 3 No. 4 (2026): In Progress
Publisher : Teewan Journal Solutions

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62710/9kqsdn56

The 2D:4D ratio (index to ring finger length) is a non-invasive biomarker of prenatal sex hormone exposure, consistently reported to be lower in males than in females. However, data on this ratio among Indonesian adolescents remain limited. This study analyzed the correlation between the 2D:4D ratio and sex among junior high school students at SMP Methodist Antiokhia Pancurbatu. An observational analytic cross-sectional study used total sampling of 394 respondents (198 males, 196 females). Finger lengths were measured with a millimeter ruler, and the ratio was calculated by dividing 2D length by 4D length. Data were tested for normality with the Kolmogorov-Smirnov test and compared between sexes using the Mann-Whitney U test. Mean index and ring finger lengths were 6.56 ± 0.55 cm and 6.46 ± 0.63 cm, with an overall mean 2D:4D ratio of 1.02 ± 0.10. Absolute finger lengths differed significantly between sexes for both the index finger (U = 12539.00; Z = −6.119; p < 0.001) and ring finger (U = 12978.00; Z = −5.714; p < 0.001), with males having longer fingers. However, the 2D:4D ratio did not differ significantly between males (1.018 ± 0.096) and females (1.025 ± 0.099) (U = 18560.00; Z = −0.749; p = 0.454). These findings suggest that absolute finger dimensions reflect clear postnatal sexual dimorphism, whereas the 2D:4D ratio shows only a very small, statistically undetectable difference in this population, likely influenced by measurement precision and sample characteristics.

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