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All Journal Pharmasipha Pharmed: Journal of Pharmaceutical Science and Medical Research SCIENTIA JOURNAL Jambura Journal of Health Sciences and Research Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Prima Medika Sains Jurnal Kesehatan Tambusai PRIMER (Prima Medical Journal) Buletin Kedokteran dan Kesehatan Prima Jurnal Pengmas Kestra (JPK)
Reh Malem br Karo
Program Studi Farmasi Klinis, Fakultas Kedokteran, Kedokteran Gigi Dan Ilmu Kesehatan Universitas Prima Indonesia Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Perbandingan Efektivitas Antibakteri Terhadap Salmonella Typhii Dari Ekstrak Etanol Buah Mahkota Dewa (Phaleria macrocarpa), Daun Pepaya (Carica papaya) Dan Buah Pare (Momordia charantina) Karor, Reh Malem br; Duha, Kristin Berlianta; Natali, Oliviti; Nasution, Sri Wahyuni; Nasution, Sri Lestari Ramadhani; Nasution, Ali Napiah
SCIENTIA JOURNAL Vol 7 No 2 (2018): SCIENTIA JOURNAL
Publisher : Universitasdiwangsa Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (698.671 KB)

Abstract

Salmonella adalah bakteri gram negative dan terdiri dari Famili Enterobacteriaceace. Salmonella merupakan bakteri patogen enterik yang menjadi penyebab utama penyakit bawaan dari makanan (foodborne disease). Tujuan dari penelitian ini adalah untuk membandingkan dan mengetahui efetivitas ektrak etanol buah mahkota dewa (Phaleria Macrocarpa), daun Pepaya (Carica Papaya), dan buah Pare (Momordia charantina) dalam menghambat pertumbuhan bakteri Salmonella typhii. Metode penelitian yang digunakan dalam penelitian ini adalah metode difusi cakram untuk melihat efektivitas sampel yang diuji dengan model Posttest Only Control Group Design. Semua data hasil penelitian dianalisa menggunakan program SPSS 25 dengan Uji One Way Anova. Dari hasil skrining fitokimia didapati ekstrak etanol Buah mahkota dewa memiliki kandungan fitokimia berupa Alkaloid, Saponin, Flavonoid, Tanin, dan Polifenol, sedangkan ekstrak etanol daun papaya memiliki kandungan fitokimia berupa alkaloid, Steroid dan Triterpenoid, Saponin, serta Polifenol dalam jumlah yang lebih sedikit, di sisi lain ekstrak buah Pare memiliki kandungan alkaloid, steroid dan triterpenoid, flavonoid, dan tannin dalam jumlah yang sedikit serta memiliki kandungan saponin dan polifenol yang cukup tinggi. Sedangkan dari hasil uji efektivitas, terdapat perbedaan yang secara statistik bermakna antara masing-masing konsentrasi ekstrak etanol buah Mahkota Dewa (Phaleria macrocarpa), daun Pepaya (Carica papaya), dan Buah Pare (Momordia charantina) (Nilai P < 0.05), sementara, dari hasil perbandingan ketiga jenis ekstrak tersebut dijumpai adanya perbedaan yang secara statistik bermakna dari ketiga sampel dari masing-masing konsentrasi dengan Nilai P < 0.05. Kesimpulan dari penelitian ini ketiga sampel penelitian tersebut efektif dalam menghambat pertumbuhan Salmonella Thypii dengan buah Pare (Momordia charantina) yang paling efektif pada konsetrasi yang tinggi dan daun Papaya (Carica papaya) pada konsentrasi yang lebih rendah.
Penentuan Kandungan Radionuklida Alam dan Unsur Logam pada Tanah Pertanian Desa Tiga Panah, Kab. Karo, Sumatera Utara Dengan Menggunakan Metode XRF Reh Malem br Karo
PRIMER (Prima Medical Journal) Vol. 5 No. 1 (2020): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v3i1.1112

Abstract

The aim of this study to monitoring radionuclide and elemental composition of agricultural soils from sub district Tiga Panah, Karo Regency, North Sumatera, Indonesia. This study using XRF spectrometric method. The natural radionuclides found in four types of soil samples (soil of chili (Capsicum annum L) code B1, soil of Corn (Zea Mays) ) code B2, soil of Broccoli (Brassica oleracea  L.)) ) code B3 and soil control (code B4) were Thorium and Uranium. The concentration of Th  were 27,5 mg/kg; 19,8mg/kg, 22,6 mg/kg; 24,7 mg/kg, respectively and the concentration of Uranium were 3,1mg/Kg;<0,4 mg/kg;4,9 mg/kg;3,1mg/kg, respectively. Some mean concentrations of these radionuclides are comparable to values from other locations around the world and the others higher. The XRF analysis revealed some elements in agricultural soil sub district Tiga Panah, Karo namely K, P, Ca, Cr, Mn, Fe, Co,Al, Na, Mg, Si, Cu and Zn. The concentration of Aluminium, Silicate and Phospor were found higher than the other elements Keywords: Radionuclide, XRF,  Agricultural Soil, Metal
Identifikasi Asam Lemak dari Minyak Biji Alpukat (Persea americana Mill.) dan Uji Antibakteri terhadap Staphylococcus aureus Wardah Fitria Tanjung; Reh Malem br Karo; Windi Wildani; Afri Abdiansyah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 1 (2022): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i1.7384

Abstract

The cause of infectious diseases that often occur in humans can be caused by pathogenic bacteria such as Staphylococcus aureus. The high rate of resistance caused by Staphylococcus aureus makes scientists continue to try to find secondary metabolites for safe medicinal ingredients. This study aims to identify fatty acids and determine the potential of avocado seed oil (BA) against Staphylococcus aureus. This type of research is a laboratory experimental research. The identification of fatty acids that make up BA oil is carried out by gas chromatography (GC) analysis, resulting in several free fatty acids (ALB) in the identified BA oil, such as saturated fatty acids and unsaturated fatty acids. The highest percent of three ALB components of BA oil were found in linoleic acid (26.182%), oleic acid (17.05%), and palmitic acid (12.21%). While the antibacterial activity test was carried out using the disc diffusion method, the variations in the concentration of BA oil used were 25%, 50%, 75%, and 100% with dimethyl sufoxide as K(-) and ciprofloxacin as K(+). Based on the antibacterial activity test, it is known that BA oil can inhibit the growth of Staphylococcus aureus bacteria with a weak category of <10 mm.
Skrining Fitokimia dan Aktivitas Antibakteri Fraksi N-Heksan Ekstrak Metanol Daun Kerai Payung (Filicium decipiens) terhadap Staphylococcus epidermidis Windi Wildani; Reh Malem br Karo; Wardah Fitria Tanjung; Afri Abdiansyah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 1 (2022): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i1.7382

Abstract

Kerai Payung (Filicium decipiens) belongs to the Sapindaceae family, which contains several active compounds that can be used as antibacterial. This study aims to determine secondary metabolites contained in the parasol leaf and the antibacterial activity of n-hexane fraction of the parasol leaf against Staphylococcus epidermidis bacteria. Identification of compound components in the n-hexane fraction of Kerai Payung leaves was carried out qualitatively by TLC using a solvent ratio of n-hexane: ethyl acetate (9:1), (8:2) and (7:3). The best separation result was using nhexane:ethyl acetate (7:3) solvent to produce 7 spots visible at 366 nm UV. The antibacterial activity was tested using the disc diffusion method (Kirby and Bauer diffusion). The concentration variations of the n-hexane fraction were 25%, 50%, 75%, 100%, control (+) cifroploxacin and control (-) DMSO (Dimethyl sulfoxide). The results of the antibacterial test against Staphylococcus epidermidis showed that the average value of the largest inhibition zone diameter was obtained at a concentration of 75%, which was 12.77 mm. The concentration groups of 25%, 50%, and 100% were 9.77 mm, 11.42 mm, 10.75 mm, respectively. Meanwhile, the K(+) group, namely Cifrofloxacin, was 31.95 mm.
Penentuan Kadar Flavonoid Total Daun Saputangan (Maniltoa Grandiflora (A.Gray) Scheff) dan Kemampuannya sebagai Antioksidan Jhon Patar Sinurat; Reh Malem Br Karo
Jurnal Dunia Farmasi Vol 6, No 2 (2022): Edisi April
Publisher : Program Studi Farmasi, Fakultas Farmasi dan Kesehatan, Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v6i2.5143

Abstract

Pendahuluan: Tumbuhan Saputangan biasanya hanya dimanfaatkan sebagai tanaman hias. Kenyataannya, daun saputangan mengandung senyawa flavonoid berdasarkan hasil skrining fitokimia yang dilakukan. Senyawa flavonoid memiliki aktivitas antioksidan yang dapat melindungi tubuh dari serangan radikal bebas dan dapat memperlambat munculnya penyakit kronis. Maka diperlukan untuk menentukan kadar senyawa flavonoid total di dalam daun saputangan dan mengukur aktivitas antioksidannya. Tujuan: Penentuan kadar flavonoid total menggunakan metode Spektrofotometri UV-Visibel dan mengukur IC50 sebagai antioksidan daun saputangan menggunakan metode DPPH (Diphenyl Picryl Hidrazil). Metode: Skrining menggunakan FeCl3, NH3, Alkali dan Pb(CH3COO)2. Proses maserasi dilakukan menggunakan etanol dan direndam dalam maserator selama lebih dari 24 jam. Pengukuran kadar flavonoid total menggunakan spektrofotometer UV-Visibel pada panjang gelombang kuersetin maksimum yaitu 442 nm. Hasil: Persamaan regresi linier untuk kurva kalibrasi quercetin yang dihasilkan adalah persamaan y = 0,0155x + 0,0387 dengan nilai korelasi (R2) sebesar 0,9943. Regresi linier antioksidan daun saputangan terhadap persentase hambatan adalah y = 0.6899x + 1.5616 dengan korelasi (R2) sebesar 0.9895. Daun Saputangan mengandung senyawa flavonoid yang terbukti berdasarkan hasil skrining. Sedangkan berat ekstrak setelah dipartisi menggunakan etil asetat dan n-heksana adalah 50 gr. Kadar flavonoid total pada daun saputangan adalah 33,87 mg QE/g ekstrak atau 33,87%. Nilai IC50 sebesar 70,2108 ppm yang dikategorikan sebagai antioksidan pada tingkat sedang. Kesimpulan: Kandungan flavonoid total adalah 3,87 mg QE/g ekstrak atau 33,87% dan dikategorikan sebagai antioksidan pada tingkat sedang.
THE EFFECT OF DRUG COUNSELING ON HYPERTENSION PATIENT'S COMPLIANCE IN A HOSPITAL IN MEDAN CITY etha tesalonika tamba; Reh Malem Br Karo; Razoki Razoki; Elfia Neswita; Erida Novriani
Jambura Journal of Health Sciences and Research Vol 4, No 3 (2022): OKTOBER: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v4i3.15100

Abstract

Pemahaman pasien terhadap pengobatan merupakan faktor kunci untuk terjadinya kepatuhan dalam pengobatan sehingga didapatkan terapi yang optimal dan efektif. Namun kenyataannya masih banyaknya pasien yang tidak patuh dalam pengobatan terutama pada penyakit hipertensi. Hipertensi dapat memicu penyakit lainnya / komplikasi sehingga dapat merusak organ-organ vital dan mengancam kualitas hidup seseorang. Untuk mencegah hal tersebut maka dibutuhkan kepatuhan pasien hipertensi dalam meminum obat dimana konseling menjadi sektor penerapan konsep asuhan kefarmasian dengan tujuan menambah ilmu perihal obat, penyakit serta harapannya mampu memahamkan penderita perihal peran obat untuk kesembuhan penyakit. Kebaruan penelitian ini karena meneliti tentang pengaruh konseling obat terhadap kepatuhan pasien  hipertensi di salah satu rumah sakit. Tujuan penelitian ini adalah untuk mengetahui apakah ada pengaruh konseling obat terhadap kepatuhan pasien hipertensi rawat jalan di salah satu rumah sakit di Kota Medan. Metode Penelitian dilakukan secara eksperimental dengan menggunakan pra- eksperimental (Pre-Experimental) dan rancangan The One Group Pretest – Posttest Design. Penelitian ini dilakukan di salah satu rumah sakit kota medan selama bulan April 2022. Populasi adalah Pasien di salah satu rumah sakit di Kota Medan yang memenuhi kriteria inklusi dan ekslusi. Sebanyak 39 pasien yang memenuhi kriteria diberikan kueisioner MMAS-8 lalu dilakukan analisa data menggunakan Uji Normalitas, Paired T-Test, Regresi Linear Sederhana dan Pengujian Hipotesis Parsial. Hasil penelitian ini didapatkan nilai Uji Normalitas, paired T-Test, Regresi linear dan pengujian hipotesis parsial secara berturut-turt adalah 0,05; 0,05; 0,01 dan 0,00. probability 0.05. Kesimpulan ada pengaruh konseling obat terhadap kepatuhan pasien hipertensi rawat jalan di salah satu rumah sakit di Kota Medan.Kata kunci: Konseling Obat; Kepatuhan; Hipertensi AbstractPatient understanding of treatment is a key factor for adherence to treatment so that optimal and effective therapy is obtained. However, in reality there are still many patients who do not comply with treatment, especially in hypertension. Hypertension is also a trigger for complications that can damage vital organs and threaten a person's quality of life. Therefore, patient compliance is needed in taking hypertension medication. Counseling is a sector of applying the concept of pharmaceutical care with the aim of increasing knowledge about drugs, diseases and the hope of being able to understand patients about the role of drugs for healing disease. The novelty of this study is because it examines the effect of drug counseling on the adherence of hypertensive patients in one of the hospitals. The purpose of this study was to determine whether there is an effect of drug counseling on the adherence of outpatient hypertension patients at a hospital in Medan City. Methods The research was conducted experimentally using a pre- experimental (Pre-Experimental) and The One Group Pretest – Posttest Design. This research was conducted at one Medan city hospital for 1 month in April 2022. The population was patients at one Medan city hospital who met the inclusion and exclusion criteria. A total of 39 patients who met the criteria were given a MMAS-8 questionnaire and then analyzed the data using the Normality Test, Paired T-Test, Simple Linear Regression and Partial Hypothesis Testing. The results of this study obtained a significant value of 0.000. The conclusion is that there is an effect of drug counseling on the compliance of outpatient hypertension patients in a hospital in Medan City.Keywords: Drug Counseling; Adherance; Hypertension
Skrinning fitokimia komponen bioaktif Parem Karo Sembiring, Novitaria Br.; Lubis, Asyrun Alkhairi; Karo, Reh Malem Br; Hidayat, Andri
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 2 (2023): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i2.4798

Abstract

Param Karo atau disebut juga Kuning Bergeh, memiliki khasiat untuk menurunkan suhu tubuh ketika demam. Berdasarkan wawancara dengan pembuat param Karo, di Kelurahan Pekan Bahorok, Sumatera Utara, sediaan ini terbuat dari buah pala (Piperis Nigri Fructus), jahe (Zingiberis Officinalis Rhizoma), bangle (Zingiber purpureum), lempuyang (Zingiber cassumunar), kencur (Kaemferia galanga), temulawak (Curcuma xanthoriza), temu kunci (Boesenbergia pandurata), dan tepung beras (Oryza Sativa) yang dihaluskan, kemudian dibentuk bulat-bulat ukuran kecil. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder Param Karo yang belum pernah diteliti. Metode penelitian ini eksperimental dengan menguji metabolit sekunder param Karo menggunakan reagen-reagen skrinning fitokimia. Hasil pengujian skrinning fitokimia param Karo positive mengandung alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Sehingga dapat disimpulkan param Karo mengandung metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Meskipun, bahan-bahan dalam pembuatan param Karo sudah melewati proses pemanasan, komponen senyawa bioaktif khususnya metabolit sekunder tidak rusak dan dapat dipertahankan.
UTILIZATION OF ORGANIC WASTE AS LIQUID ORGANIC FERTILIZER: UTILIZATION OF ORGANIC WASTE AS LIQUID ORGANIC FERTILIZER Sinurat, Jhon Patar; Br Karo, Reh Malem
JURNAL PENGMAS KESTRA (JPK) Vol. 2 No. 2 (2022): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.712 KB) | DOI: 10.35451/jpk.v2i2.1480

Abstract

Garbage accumulation is still a problem that pollutes the environment. There is still a lot of waste or organic waste that has not been managed properly because people think that organic waste can decompose naturally. If left unchecked, this will cause an unpleasant odor and disturb the environment. One way of processing organic waste is to make it into Liquid Organic Fertilizers (LOF). LOF is a liquid resulting from the fermentation of organic waste. LOF contains nutrients such as phosphorus, nitrogen, potassium, and others that are beneficial to plants and soil. The method used in carrying out community service activities is through lecture and demonstration methods. The material is presented through lectures using an LCD and direct demonstrations of making LOF from organic waste. Increased understanding of participants will be measured through pre-test and post-test. This community Service activity was carried out at the Grandmed Lubuk Pakam Hospital for 10 participants who acted as cleaners. The result obtained is Liquid Organic Fertilizer (LOF) which is brownish-yellow in color and gives off a rotten aroma after being fermented for 1 week. In addition, all 10 participants experienced an increase in post-test scores compared to pre-test scores after participating in this activity, where the average score increased by 31.5. This value can be interpreted as seminar participants having experienced increased understanding and being able to participate in this community service activity properly.
Socialization of The Abuse and Danger of Formaline as A Preservative in Food Materials at Lubuk Pakam District Sinurat, Jhon Patar; Br Karo, Reh Malem; Syarifuddin, Shofian
JURNAL PENGMAS KESTRA (JPK) Vol. 3 No. 1 (2023): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v3i1.1767

Abstract

The addition of formalin is often misused by making it a food preservative. This happens because the price of formalin is cheaper than natural food preservatives and synthetic food preservatives. Despite realizing that formalin is very dangerous because it is carcinogenic and irritating to the body. Food ingredients containing formaldehyde are commonly found in tofu and meatball products. While meatballs and years are food ingredients that are much liked by the community. Both types of food contain lots of protein and carbohydrates which are good for health. Community service activities are carried out through outreach activities using lectures, discussion, and question-and-answer methods. The number of participants who participated in this PkM activity was 20 people aged in the 25-45 year range who were in the Lubuk Pakam sub-district. This PkM activity uses a system of pre-test and post-test in evaluating the level of increase in participants' knowledge. In addition, the level of satisfaction of participants in PkM activities was measured using a questionnaire. The results of the service show that PkM activities have provided additional knowledge to the community so that they are more careful in choosing food ingredients for consumption so that they will avoid the dangers of misuse of formaldehyde in food. Based on the evaluation carried out on the PkM activities, there was an increase in the average knowledge of the PkM participants by 30% after being given socialization. While the majority of 95% (19 PkM participants) were satisfied with the implementation of this PkM activity.
Counseling of The Danger of Rhodamin-B in Chili Sauce Around of The Traditional Market Tanjung Morawa Sinurat, Jhon Patar; Br Karo, Reh Malem; Sirait, Reni Aprinawaty; Yanti, Dian Anggri
JURNAL PENGMAS KESTRA (JPK) Vol. 3 No. 2 (2023): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v3i2.2003

Abstract

Food products currently compete with each other based on price and physical appearance. Many traders are competing to make food with attractive colors by adding synthetic dyes. However, in order to make big profits, there are some who make food products but are not honest. Such as adding rhodamine-B, which is a textile dye, as a coloring agent in foods such as chili sauce. People often use chili sauce to add a spicy taste to food. If there is rhodamine-B in food, it can cause health problems such as stomach inflammation, skin irritation, respiratory tract and liver cancer and can cause death if it accumulates in large quantities. This community service activity through outreach will increase public knowledge about the dangers of rhodamine-B. Where PkM material will be presented through lecture, discussion and question and answer methods. The number of PkM participants is 20 traders who sell around the Tanjung Morawa traditional market, where PkM participants are determined randomly. The increase in participants' knowledge was measured through pre and post-tests. The service results show that there are several chili sauce products that contain certain levels of rhodamine-B so it is not recommended to use this chili sauce. Apart from that, through this outreach activity, PkM participants experienced an increase in average knowledge about the dangers of rhodamine-B by 26.5. Where the average pre-test score is 52 and post-test is 78.5, which means there is an increase in knowledge after the counseling activities.
Co-Authors Afri Abdiansyah Afri Abdiansyah Andri Hidayat, Andri Ayuningsari, Laras Br Sihite, Rani Marselina Br Turnip, Nur Ulina M. Cahya, Cucu Arum Dwi Christine, Yesina Duha, Kristin Berlianta Elfia Neswita Erida Novriani etha tesalonika tamba Fadillah, Qori Fibrini, Dewi Fioni, Fioni Ginting, Wira Maria Harahap, Rahmat Ali Putra Hoswari, Cindy Natasya Husna, Miftahul Khairunnisa Batubara Lina, Juliana Lubis, Asyrun Alkhairi Manao, Merlianasari Meutia, Rena Nasution, Ali Napiah Nasution, Sri Lestari Ramadhani Natali, Oliviti Neswita, Elfia purba, marina novelly br Razoki Razoki Razoki, Razoki Rizki, Nadya Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Sinurat, Jhon Patar Sirait, Reni Aprinawaty Suci Wulandari Syarifuddin, Aminah Syarifuddin, Shofian Tampubolon, Regina Elianda Tanamal, Claudia Telova, Yurizki Theresia, Yohani Wardah Fitria Tanjung Wardah Fitria Tanjung Windi Wildani Windi Wildani Yanti, Dian Anggri Yudha, M