Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal CHEMPUBLISH JOURNAL Jurnal Farmasi dan Sains Indonesia (JFSI)
Khusna, Mursyidah Lathifatul
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Medicine & Pharmacology Neuroscience

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Variasi Konsentrasi Kombinasi Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) dan Daun Sirih (Piper betle) Menggunakan Metode Hidroekstraksi Seabagai Antibakteri Seara In Vitro Tilarso, Dara Pranidya; Muadifah, Afidatul; Khusna, Mursyidah Lathifatul
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p1-9

Abstract

Infectious diseases caused by bacteria are diseases that often arise in society. Bacteria that cause infection include Staphylococcus aureus and Escherichia coli. Bacterial growth can be inhibited with antibiotics. However, some microbes have become resistant to antibiotics so that the use of antibacterials from natural ingredients has begun to be used. Star fruit (Averrhoa bilimbi L.) contains flavonoids, tannins, saponins which are useful as antibacterials. Betel leaf (Piper betle) contains saponins, tannins, flavonoids and phenolic compounds which have activity in inhibiting bacteria. The purpose of this study was to determine the antibacterial activity of a combination of star fruit and betel leaf extracts. The method used in this study was the hydroextraction method with various concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100%. Antibacterial activity testing using disc diffusion. The results showed that the combination of star fruit and betel leaf extracts had optimum inhibitory activity at a concentration of 100% with an inhibition diameter of 11.05 mm for Staphylococcus aureus which was strong and with a diameter of 9.17 mm for Escherichia coli which was moderate.
Antibacterial Activity of Combination of Betel Leaf Extract and Star Fruit Using Hydroextraction Method Tilarso, Dara Pranidya; Muadifah, Afidatul; Handaru, Windu; Pratiwi, Putri Indah; Khusna, Mursyidah Lathifatul; Tarigan, Indra Lasmana
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.21736

Abstract

Antibacterial compounds are bioactive substances capable of inhibiting bacterial growth by disrupting the metabolism and cellular processes of pathogenic microorganisms. Natural plant-derived compounds have been widely explored for their antibacterial properties, with star fruit (Averrhoa bilimbi L.) and betel leaf (Piper betle) recognized for their potent antimicrobial effects. This study aimed to evaluate the antibacterial activity of a combination of star fruit and betel leaf extracts against Escherichia coli and Staphylococcus aureus, two clinically significant bacterial pathogens. The extraction process was performed using hydro-extraction at different temperatures (40°C, 50°C, 60°C, and 90°C) to determine the optimal conditions for bioactive compound yield. Antibacterial activity was assessed using the disc diffusion method, measuring inhibition zones to indicate bacterial susceptibility. The results demonstrated that the optimal inhibitory effect occurred at 50°C, producing an inhibition zone of 19.75 mm for Staphylococcus aureus and 11.75 mm for Escherichia coli. These findings suggest that temperature plays a critical role in maximizing the antibacterial potential of plant extracts. The study highlights the potential application of star fruit and betel leaf extracts as natural antibacterial agents, particularly against Gram-positive and Gram-negative bacteria. Further research is recommended to explore the mechanism of action, phytochemical composition, and potential synergy of these extracts in antimicrobial formulations.
Co-Authors Handaru, Windu Indra Lasmana Tarigan Muadifah, Afidatul Pratiwi, Putri Indah Tilarso, Dara Pranidya