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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik CHEMPUBLISH JOURNAL Jurnal SOLMA Pharmasipha Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Farmasi dan Sains Indonesia (JFSI) JI-KES (Jurnal Ilmu Kesehatan)
Tilarso, Dara Pranidya
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Uji efektivitas analgetik kombinasi ekstrak daun pepaya dan daun kelor pada mencit galur Swiss Webster dengan metode Hot Plate Putri, Amalia Eka; ‘Alimah, Erlisa Maratul; Tilarso, Dara Pranidya
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol. 7 No. 2 (2023): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v7i2.10488

Abstract

ABSTRACT Analgesic is drug that function to reduce or eliminate pain without reducing consciousness. Analgesic treatment was developed by utilizing herbal plants. Papaya leaves (Carica papaya L.) and moringa leaves (Moringa oleifera L.) contain secondary metabolites of flavonoids which function as analgesics. The mechanism of flavonoids as analgesics is to inhibit the action of the cyclooxygenase enzyme which will reduce the production of prostaglandins by arachidonic acid so as to reduce pain. This study aims to determine the analgesic effectiveness of a combination of papaya and moringa leaf extracts in Swiss Webster male mice using the Hot Plate method. Papaya leaf extracts and Moringa leaves were made in combination with comparative doses were 1:2 (200mg/KgBB : 400mg/KgBB), 2:2 (400mg/KgBB : 400mg/KgBB), dan 2:1 (400mg/KgBB : 200mg/KgBB). The control groups used for comparison were negative controls (1% CMC Na suspension) and positive controls (mefenamic acid suspension). The analgetic test method used was the Hot Plate method and the stretching response was calculated at the 0th, 30th, 60th, 90th and 120th minute. The results showed that the dose combination that had the best percentage of stretch protection and analgesic effectiveness was the 2:2 combination (400mg/KgBB : 400mg/KgBB) of 59% and 103% respectively. The results of the study were analyzed using SPSS, namely using one way ANOVA and then tested with the Post Hoc Tukey test. The results showed a significant value of the positive group > 0.05 with the DPDK group 2:2, which means there was no significant difference and the negative control group showed a significant value of <0.05 with all treatment groups which means that there was a significant difference. Keywords: Papaya leaves, Moringa leaves, analgesics, effective dose, Hot Plate method   ABSTRAK Analgetik merupakan obat yang berfungsi untuk mengurangi atau menghilangkan rasa nyeri tanpa mengurangi kesadaran. Pengobatan analgetik dikembangkan dengan memanfaatkan tumbuhan herbal. Daun pepaya (Carica papaya L.) dan daun kelor (Moringa oleifera L.) mengandung senyawa metabolit sekunder flavonoid yang berfungsi sebagai analgetik. Mekanisme flavonoid sebagai analgetik yaitu menghambat kerja enzim sikooksigenase yang akan mengurangi produksi prostaglandin oleh asam arakidonat sehingga mampu mengurangi rasa nyeri. Penelitian ini bertujuan untuk mengetahui efektivitas analgetik kombinasi ekstrak daun pepaya dan daun kelor pada mencit jantan galur Swiss Webster dengan metode Hot Plate. Ekstrak daun pepaya dan daun kelor dibuat kombinasi dengan dosis perbandingan 1:2 (200mg/KgBB : 400mg/KgBB), 2:2 (400mg/KgBB : 400mg/KgBB), dan 2:1 (400mg/KgBB : 200mg/KgBB). Kelompok kontrol yang digunakan untuk pembanding yaitu kontrol negatif (suspensi CMC Na 1%) dan kontrol positif (suspensi asam mefenamat). Metode uji analgetik yang digunakan yaitu metode Hot Plate dan dihitung respon geliatnya pada menit ke-0, ke-30, ke-60, ke-90, dan ke-120. Hasil menunjukkan bahwa kombinasi dosis yang memiliki persentase proteksi geliat dan efektivitas analgetik yang paling baik yaitu kombinasi 2:2 (400mg/KgBB : 400mg/KgBB) masing-masing sebesar 59% dan 103%. Hasil penelitian dianalisis dengan menggunakan SPSS yaitu menggunakan one way ANOVA kemudian diuji dengan uji Post Hoc Tukey. Hasil penelitian menunjukkan nilai signifikan kelompok positif > 0,05 dengan kelompok DPDK 2:2 yang berarti tidak terdapat perbedaan yang signifikan dan kelompok kontrol negatif menunjukkan nilai signifikan <0,05 dengan semua kelompok perlakuan yang berarti bahwa terdapat perbedaan yang signifikan. Kata Kunci: Daun pepaya, daun kelor, analgetik, dosis efektif, metode Hot Plate
The Relationship between HbA1c and Glucosuria in Diabetes Mellitus (DM) Patients: Hubungan HbA1c dengan glukosuria Pada Penderita Diabetes Mellitus (DM) Nurjanah, Mutia Hariani; Wijaya, Anas Fadli; Meri, Meri; Tilarso, Dara Pranidya; Siswidiani, Maya Diva
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 6 No. 2 (2023): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v6i2.1727

Abstract

Diabetes mellitus is a condition of abnormalities in blood glucose metabolism that can cause various macroangiopathy complications such as disorders of the peripheral blood vessels, heart blood vessels, cerebral blood vessels as well as microangipathic complications such as diabetic retinopathy disorders, nephropathy and neuropathy. HbA1c describes the level of sugar in the blood for the last 3 months. Glucose is not found in normal urine because it is reabsorbed back into the blood vessels by renal filtration. The aim of this study was to determine the relationship between HbA1c levels and glucosuria in people with diabetes mellitus. The design of this study is a cross-sectional approach to DM patients. The sampling technique used was purposive sampling. Data analysis was carried out by means of Spearman's rank correlation test. Results Correlation analysis showed that there was a significant relationship between HbA1c levels and glucosuria in DM patients p-value 0.005 with a coefficient value of 0.597. The conclusion from this study is that there is a significant relationship with a strong correlation strength and a positive correlation direction for DM sufferers.
Variasi Konsentrasi Kombinasi Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) dan Daun Sirih (Piper betle) Menggunakan Metode Hidroekstraksi Seabagai Antibakteri Seara In Vitro Tilarso, Dara Pranidya; Muadifah, Afidatul; Khusna, Mursyidah Lathifatul
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p1-9

Abstract

Infectious diseases caused by bacteria are diseases that often arise in society. Bacteria that cause infection include Staphylococcus aureus and Escherichia coli. Bacterial growth can be inhibited with antibiotics. However, some microbes have become resistant to antibiotics so that the use of antibacterials from natural ingredients has begun to be used. Star fruit (Averrhoa bilimbi L.) contains flavonoids, tannins, saponins which are useful as antibacterials. Betel leaf (Piper betle) contains saponins, tannins, flavonoids and phenolic compounds which have activity in inhibiting bacteria. The purpose of this study was to determine the antibacterial activity of a combination of star fruit and betel leaf extracts. The method used in this study was the hydroextraction method with various concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90% and 100%. Antibacterial activity testing using disc diffusion. The results showed that the combination of star fruit and betel leaf extracts had optimum inhibitory activity at a concentration of 100% with an inhibition diameter of 11.05 mm for Staphylococcus aureus which was strong and with a diameter of 9.17 mm for Escherichia coli which was moderate.
Uji Efektivitas Antioksidan Serum Ekstrak Daun Randu (Ceiba Pentandra (L.) Gaertn.) Dengan Metode DPPH Muadifah, Afidatul; Ummah, Ratih Salimil; Tilarso, Dara Pranidya
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p43-54

Abstract

The development of cosmetics from natural ingredients has been widely applied in several cosmetic industries, one of the developing cosmetic dosage forms is serum. One of the plants that can be used for serum is randu leaf (Ceiba pentandra (L.) Gaertn.) which contains secondary metabolites including flavonoids, alkaloids, saponins, and tannins which act as natural antioxidants for antiaging. This study aims to determine the optimum levels of flavonoids in randu leaf extract using a UV-Vis spectrophotometer, physical quality of preparations and antioxidant activity in serum preparations using the DPPH method. In determining the levels of flavonoids in the randu leaf extract with concentration series of 20 ppm, 40 ppm, 60 ppm using a UV-Vis spectrophotometer, the results obtained were the optimum concentration of cotton leaf extract in the 60 ppm concentration series, which was 229.3 µg/ml. Then the serum preparation was made, it was found that the serum preparations of randu leaf extract and vitamin C had fulfilled the physical quality test requirements. The antioxidant activity test of serum preparations was continued using the DPPH method using a UV-Vis spectrophotometer and ascorbic acid as a comparison. The ????????50 value for the randu leaf extract serum preparation was 75.0159 ppm which was classified as having strong antioxidant activity while the vitamin C serum preparation was 4.674 ppm which was classified as having very strong antioxidant activity
Antibacterial Activity of Combination of Betel Leaf Extract and Star Fruit Using Hydroextraction Method Tilarso, Dara Pranidya; Muadifah, Afidatul; Handaru, Windu; Pratiwi, Putri Indah; Khusna, Mursyidah Lathifatul; Tarigan, Indra Lasmana
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.21736

Abstract

Antibacterial compounds are bioactive substances capable of inhibiting bacterial growth by disrupting the metabolism and cellular processes of pathogenic microorganisms. Natural plant-derived compounds have been widely explored for their antibacterial properties, with star fruit (Averrhoa bilimbi L.) and betel leaf (Piper betle) recognized for their potent antimicrobial effects. This study aimed to evaluate the antibacterial activity of a combination of star fruit and betel leaf extracts against Escherichia coli and Staphylococcus aureus, two clinically significant bacterial pathogens. The extraction process was performed using hydro-extraction at different temperatures (40°C, 50°C, 60°C, and 90°C) to determine the optimal conditions for bioactive compound yield. Antibacterial activity was assessed using the disc diffusion method, measuring inhibition zones to indicate bacterial susceptibility. The results demonstrated that the optimal inhibitory effect occurred at 50°C, producing an inhibition zone of 19.75 mm for Staphylococcus aureus and 11.75 mm for Escherichia coli. These findings suggest that temperature plays a critical role in maximizing the antibacterial potential of plant extracts. The study highlights the potential application of star fruit and betel leaf extracts as natural antibacterial agents, particularly against Gram-positive and Gram-negative bacteria. Further research is recommended to explore the mechanism of action, phytochemical composition, and potential synergy of these extracts in antimicrobial formulations.
PENGARUH METODE MASERASI DAN SOKHLASI TERHADAP KANDUNGAN SENYAWA ANTIOKSIDAN DAUN Pluchea indica L. DENGAN METODE LC-MS Afidatul Muadifah; Tilarso, Dara Pranidya; Sowe, Momodou Salieu; Tarigan, Indra Lasmana; Ngibad, Khoirul; Yuliantari, Sonia Devi
Chempublish Journal Vol. 8 No. 2 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i2.36869

Abstract

Pluchea indica L. is a plant have some secondary metabolite compounds namely flavonoids, alkaloids, tannins, saponins, terpenoids, and phenols that have antioxidants activity. The purpose of this study was to compare the content of antioxidant compounds analyzed using LC-MS and determine the relationship of antioxidant activity through the DPPH test on P. indica leaves extracted by maceration and soxhlation. The extracts from maceration and soxhlation of P. indica leaves were analyzed using LC-MS to determine the composition of the compounds contained therein then continued with the antioxidant activity test using the DPPH method. In the antioxidant activity test using DPPH, each extract was made 3 variations of concentration, namely 10 ppm, 50 ppm, and 100 ppm, and measured based on the absorbance of DPPH at a wavelength of 515 nm using a UV-vis spectrometer. The results of analysis using LC-MS on macerated extracts of P. indica leaves are 112 compounds consisting of flavonoids 72.4841%, phenols 9.00625%, terpenoids 6.11827%, alkaloids 6.99075%, tannins 2.2256%, and saponins 2.04458%. The Soxhlet extraction contained 116 compounds consisting of flavonoids 67.14345%, phenols 8.95854%, terpenoids 13.82165%, alkaloids 5.35637%, tannins 2.53305%, and saponins 0.2969%. The results of the antioxidant activity test using DPPH on maceration extracts have an IC50 value of 76.7576 and soxhlation 62.580 ppm. Both maceration and soxhlation extracts of P. indica leaves contain compounds that have high antioxidant potential and have good antioxidant activity, namely in the strong antioxidant category. However, the soxhlation extract has more compounds and a lower IC50 value. Thus, the more antioxidant compounds contained in an extract, the lower the IC50 value so that the better the antioxidant activity.
Uji Efektivitas Antioksidan Moisturizer Ekstrak Daun Randu (Ceiba Pentandra (L.) Gaertn.) dengan Metode DPPH Muadifah, Afidatul; Tilarso, Dara Pranidya; Putri, Amalia Eka; Sowe, Momodou Salieu
Chempublish Journal Vol. 8 No. 1 (2024): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v8i1.33234

Abstract

Dry skin can often cause psychological discomfort. Moisturizer is a preparation that is used to improve dry skin. Kapok plant (Ceiba pentandra L. Gaertn) can be used as an active ingredient of moisturizer and can be used as a treatment, where the chemical content in kapok leaves are flavonoids, saponins, alkaloids, phenolic compounds, tannins and terpenoids as antioxidants. This study aims to determine the antioxidant activity of kapok leaf extract and moisturizer preparations with DPPH method using UV-Vis spectrophotometer, physical quality of preparations and antioxidant activity of moisturizer preparations using DPPH method. Kapok leaf extract was made in various concentrations, namely 20 ppm, 40 ppm and 60 ppm. The IC50 value of kapok leaf extract is 67.4007 ppm which has strong antioxidant activity. Then variations in the concentration of kapok leaf extract were put into the formulation of moisturizer preparations, the results of moisturizer preparations of kapok leaf extract and vitamin C met the requirements of the physical quality test. The moisturizer preparation was continued and tested for antioxidant activity using the DPPH method with ascorbic acid as a comparison. The results of the IC50 value on the kapuk leaf extract moisturizer preparation are 110.065 ppm which is classified as having moderate antioxidant activity and while the vitamin C moisturizer preparation is 9.8417 ppm which is classified as having very strong antioxidant activity.
A Natural Antiseptic Alternative in Hand Sanitizer Gel : A Combination of Miana and Kemuning Leaves Extract Muadifah, Afidatul; Tilarso, Dara Pranidya; Kristijono, Ary; Ngibad, Khoirul; Salsabila, Nabila Putri
JI-KES (Jurnal Ilmu Kesehatan) Vol. 5 No. 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.266

Abstract

Abstrak Penggunaan gel hand sanitizer saat ini menjadi jalan keluar untuk menjaga kesehatan dan kebersihan tangan agar lebih praktis dan mudah dibawa. Penelitian ini bertujuan untuk menghasilkan antiseptik alami dari kombinasi ekstrak daun Miana dan Kemuning terhadap Staphylococcus aureus dan Escherichia coli dalam bentuk gel. Gel hand sanitizer dibuat dari kombinasi ekstrak daun miana dan kemuning yang menunjukkan daya hambat optimum terhadap bakteri Staphylococcus aureus dan Escherichia coli. Kombinasi ekstrak daun Miana dan Kemuning dibuat dalam 3 variasi konsentrasi (K1 = 5%: 15%), (K2 = 10%: 10%), dan (K3 = 15%: 5%). Formulasi gel hand sanitizer diuji kemampuannya sebagai antiseptik dan uji stabilitas fisik pada hari ke 0, hari ke 7, hari ke 14, hari ke 21, dan hari ke 28. Konsentrasi optimum dari kombinasi ekstrak daun miana dan kemuning sebagai antiseptik adalah pada kombinasi K3 = 15%: 5%. Kombinasi antiseptik alami K3 (NAK3) menunjukkan daya hambat sebesar 7,33 mm (terhadap Staphylococcus aureus) dan 09,00 mm (terhadap Escherichia coli) yang termasuk dalam kategori sedang. NAK3 memenuhi persyaratan untuk uji organoleptik, homogenitas, pH, kemampuan menyebar, dan adhesi, serta stabil selama penyimpanan..  Kata kunci: antiseptik, miana, kemuning, gel, hand sanitizer Abstract The use of hand sanitizer gel is currently a more practical and portable way to maintain health and hand hygiene. This study aims to generate a natural antiseptic from a combination of Miana and Kemuning leaves extract toward Staphylococcus aureus and Escherichia coli in gel formulation. The hand sanitizer gel is made from a combination of Miana and Kemuning leaves extract which shows optimum inhibition against Staphylococcus aureus and Escherichia coli bacteria. The combination of Miana and Kemuning leaves extracts was made in 3 variations of concentration (K1 = 5%: 15%), (K2 = 10%: 10%), and (K3 = 15%: 5%). The hand sanitizer gel formulation tested its ability as an antiseptic and on physical stability test on day 0, day 7, day 14, day 21, and day 28. The optimum concentration of the combination of Miana and Kemuning leaves extracts as an antiseptic is at a combination of K3 = 15%: 5%. The combination K3 Natural Antiseptic (NAK3) showed an inhibitory power of 7.33 mm (against Staphylococcus aureus) and 09.00 mm (against Escherichia coli) which was included in the moderate category. The NAK3 meets the requirements for organoleptic tests, homogeneity, pH, spreadability, and adhesion, and is stable during storage. Keywords: antiseptic, miana, kemuning, gel, hand sanitizer
Identification of Majapahit Leaf Infusion Compounds (Crescentia Cujete L.) with LC-MS and Toxicity Analysis of Artemia Salina Leach Martha, Rahma Diyan; Tilarso, Dara Pranidya; Adisyaningrum, Ega Nurgia
Prosiding Sains Nasional dan Teknologi Vol. 14 No. 1 (2024): Seminar Nasional Sains dan Teknologi 14
Publisher : Fakultas Teknik Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cancer is a disease causes by the growth of cells that are not benign and have the ability to invade and metastasize. One of the plants that has potential as herbal medicine is the Majapahit plant (Crescentia Cujete L.). This research is useful for knowing the content of compound metabolites that have anticancer activities in majapahit leaf infusion used LC-MS, and to knowing the level of acute toxicity (LC50) on majapahit leaf infusion to Artemia Salina Leach with BSLT method. The majapahit leaf extract was obtained using the infusion method by dissolving in distilled water at 90oC for 15 minutes. Toxicity test was carried out on  concentration range of 100, 200, 300, 400, 500, 600, 700, 800, 900, and 1000 ppm which were tested on Artemia Salina Leach during 24 hours. The results of testing the majapahit leaf infusion extract using LC-MS found 3 compounds having the highest concentrations is, Narirutin 4'-glycoside, Kaempferol 3-[6”-(3-hydroxy-3-methylglutaryl)glucoside] and, acacetin 7-rutinoside. The toxicity test of the acute extract of majapahit (Crescentia Cujete L.) leaf infusion using the BSLT method yielded an LC50 value of 792.8664 ppm. From the LC50 value obtained, it can be significant that the extract of majapahit leaf infusion has the potential as an anticancer by being labeled with an acquisition value of LC50 <1000 ppm. 
Peningkatan Pemahaman Tentang Beyond Use Date Sebagai Upaya Mencegah Kesalahan Penggunaan Obat Pada Masyarakat Desa Dono Sari, Tri Anita; Tilarso, Dara Pranidya; Ningsih, Devi Ayu; Anggraini, Diva Maula; Sari, Endah Luthfita
Jurnal SOLMA Vol. 14 No. 3 (2025)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v14i3.20654

Abstract

Background: Batas waktu penggunaan suatu obat yang telah diracik atau setelah kemasan primernya dibuka disebut dengan beyond use date. Masyarakat seringkali beranggapan bahwa obat yang telah dibuka dari kemasannya memiliki masa simpan hingga batas waktu kadaluarsa yang tercantum pada kemasan produk obat. Kegiatan ini bertujuan untuk meningkatkan pemahaman masyarakat desa Dono terhadap pentingnya informasi beyond use date dalam penggunaan produk obat, untuk mencegah kesalahan dalam penggunaan obat yang dapat mengakibatkan penurunan efektivitas terapeutik obat serta menimbulkan toksisitas. Metode: Kegiatan pengabdian ini menggunakan metode ceramah dengan media leaflet dan pre-post test melalui pengisian kuesioner. Pada awal kegiatan dilakukan pre-test, dilanjutkan dengan penyampaian materi, diskusi tanya jawab dan diakhiri dengan post-test. Hasil: Hasil nilai rata-rata pre-test responden sebesar 60, sedangkan nilai rata-rata post-test sebesar 93. Kegiatan ini dinilai efektif karena pemahaman masyarakat desa Dono meningkat 33% terhadap beyond use date. Kesimpulan: Dengan adanya kegiatan ini diharapkan kesalahan penggunaan obat dapat dicegah seiring dengan meningkatnya wawasan masyarakat terkait beyond use date.
Co-Authors Adisyaningrum, Ega Nurgia Afidatul Muadifah Anas Fadli Wijaya Anggraini, Diva Maula Handaru, Windu Indra Lasmana Tarigan Khusna, Mursyidah Lathifatul Kristijono, Ary Meri, Meri Muadifah, Afidatul Ngibad, Khoirul Ningsih, Devi Ayu Nurjanah, Mutia Hariani Pratiwi, Putri Indah Putri, Amalia Eka Rahma Diyan Martha Salsabila, Nabila Putri Sari, Endah Luthfita Sari, Tri Anita Siswidiani, Maya Diva Sowe, Momodou Salieu Ummah, Ratih Salimil Yuliantari, Sonia Devi ‘Alimah, Erlisa Maratul