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All Journal Poltekita : Jurnal Ilmu Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Indonesian Journal of Health Science Pharmaceutical Science Journal
Annisa Septyana Putri
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Peran Farmasis Terhadap Tingkat Kepatuhan Minum Obat, Pengetahuan, dan Tekanan Darah Pasien Hipertensi Prolanis di Puskesmas Kecamatan Pulogadung Annisa Septyana Putri; Dian Ratih Laksmitawati; Sahat Saragi
Poltekita : Jurnal Ilmu Kesehatan Vol. 16 No. 1 (2022): May
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v16i1.1104

Abstract

Tujuan penelitian adalah untuk mengetahui tingkat kepatuhan minum obat, pengetahuan, dan tekanan darah pasien hipertensi prolanis sebelum dan sesudah intervensi farmasis. Metode penelitian adalah quasi eksperimental yang dilakukan secara prospektif. Populasi penelitian adalah seluruh pasien hipertensi yang datang berobat ke Puskesmas Kecamatan Pulogadung dengan jumlah sampel 39 orang. Edukasi diberikan dengan menggunakan bantuan penyebaran leaflet dan ceramah secara online yaitu dengan bantuan Google Meeting. Sedangkan untuk reminding dilakukan melalui penulisan pesan yang bersifat motivasi, reminder, jadwal minum obat, dan informasi-informasi lain yang terkait melalui Whatsapp Group. Analisis data menggunakan statistik Uji Wilcoxon, Uji Friedmaan. Hasil penelitian yaitu terdapat perbedaan yang signifikan skor pengetahuan, kepatuhan dan jumlah pil obat yang diminum responden sebelum dan setelah intervensi dengan nilai p = 0,000 (p < 0,05) dimana terdapat peningkatan skor pengetahuan sebesar 2.46, skor kepatuhan sebesar 1.1, peningkatan jumlah pil yang dikonsumsi pada bulan ke 3 menjadi 92,182. Tekanan darah diastole dan systole juga mengalami penurunan yang signifikan setelah intervensi (p = 0.000). Kesimpulan yaitu edukasi, konseling dan reminder yang dilakukan farmasis dapat meningkatkan kepatuhan minum obat, pengetahuan pasien, dan hasil tekanan darah pada pasien hipertensi prolanis
EFEKTIVITAS TERAPI INSULIN TERHADAP GLUKOSA DARAH DAN HbA1c PASIEN DIABETES MELITUS DI RUMAH SAKIT UMUM X JAKARTA SELATAN Aulia, Gina; Azzahra, Aristi; Purwaningsih, Neneng Sri; Ismaya, Nurwulan Adi; Hasanah, Nur; Putri, Annisa Septyana; Kurniawati, Dewi Indah; Werawati, Ayu; Sayyidah, Sayyidah
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p167-172

Abstract

Diabetes mellitus is a serious and chronic condition. Diabetes mellitus patients often experience serious acute and chronic complications, even causing death. South Jakarta has the 4th highest prevalence of diabetes mellitus, namely 2.83%. The aim of this study was to analyze the effectiveness of insulin therapy by examining differences in blood glucose and HbA1c after 4 months and 8 months of therapy in diabetes mellitus patients. The research method in this research is quantitative descriptive analysis with a cohort retrospective approach. The sample in this study was 92 diabetes mellitus patients on insulin therapy who had their HbA1c checked with blood glucose routinely in 2023 taken using the purposive sampling method. The results showed that most patients were in the 56-65 years age group (45.7%), the most common gender was female (57.6%), and 76.1% of patients had comorbidities. The most widely used insulin therapy is a combination of Rapid acting and Long acting insulin (63%). The conclusion in this study was that there was no significant difference in either blood glucose levels after 4 months of therapy (P=0.442) or blood glucose levels after 8 months of therapy (P=0.148), compared with 1st month blood glucose, and there was a difference significant both HbA1c levels after 4 months of therapy (P=0.000) and HbA1c levels after 8 months of therapy (P=0.000), compared with HbA1c in the 1 month
Rational use of NSAIDs and the incidence of potential drug interactions in inpatients with osteoarthritis at the Tangerang City General Hospital Fauziah, Siva; Aulia, Gina; Nasar, Nur Afni Syariah; Putri, Annisa Septyana; Komarudin, Dede
Indonesian Journal of Health Science Vol 5 No 4 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i4.1621

Abstract

Background: Osteoarthritis (OA) is a disease that affects articular cartilage, subchondral bone, synovium, capsule, and ligaments. This disease is an overlapping disorder with different etiologies but similar biological, morphological, and clinical outcomes. The rationality of drug use in osteoarthritis must be optimized to achieve optimal therapeutic outcomes. The potential for drug interactions must also be understood to prevent unwanted effects from therapy. Objective: To determine the rationality of drug use and the potential for drug interactions in osteoarthritis patients at Tangerang City General Hospital, focusing on the four principles of appropriate drug use: appropriate patient, appropriate drug, appropriate indication, and appropriate dose. This study is a descriptive observational study with a cross-sectional design and uses retrospective data. Method: The study sample was selected using purposive sampling, considering inclusion and exclusion criteria. The study sample meeting the inclusion criteria consisted of 31 medical records (patients). The data obtained were then compared with the reference standards of the Indonesian Rheumatology Association (IRA). Results: Patient characteristics based on age showed the highest proportion in early elderly (46–55 years) at 41.9%, female gender at 71%, with joint pain location in the feet at 65%, other joints at 23%, and hands at 12.9%. The profile of prescribed osteoarthritis medications was as follows: sodium diclofenac 41.9%, meloxicam 38.7%, ketorolac 12.9%, and mefenamic acid 6.5%. The rationality of patient accuracy, medication, indications, and dosage yielded 100% data related to NSAID use in osteoarthritis patients, with the highest potential for drug interactions occurring in the combination of sodium diclofenac and bisoprolol at 18.2% at a moderate severity level. The mechanism of interaction involves NSAIDs potentially weakening the antihypertensive effects of beta-blockers. The mechanism of NSAID-induced inhibition of renal prostaglandin synthesis results in uninhibited pressor activity, leading to hypertension. Additionally, NSAIDs can cause fluid retention, which also affects blood pressure. Conclusion: The rational use of NSAIDs in terms of the right patient, right drug, right indication, and right dose was 100%, and the total number of PIAO cases found was 11 (28.2%). Of all the cases identified, 8 cases were moderate in severity and 3 cases were minor. The most common drug interactions were between Sodium Diclofenac and Bisoprolol, accounting for 18.2%. Keywords: Drug rationality NSAIDs, Osteoarthritis, Potential drug interactions.
Efektivitas ekstrak Etanol Rosemary (Rosemarinus officinalis L.) pada tikus jantan putih (Rattus Norvegicus L.) sebagai agen Hepatoprotektor Komarudin, Dede; Adriana, Yulis; Ruslihagi, Farid; Fauziah, Siva; Putri, Annisa Septyana; Aulia, Gina; Nasar, Nur Afni Syariah
Indonesian Journal of Health Science Vol 5 No 4 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i4.1622

Abstract

Latar Belakang: Hati adalah organ penting dalam tubuh manusia.kerusakan pada hati disebabkan oleh banyak faktor termasuk obat-obatan tertentu, paparan polutan, dan bahan kimia lingkungan seperti parasetamol, karbon tetraklorida, dan lain-lain. triklorometil membentuk radikal triklorometilperoksi Peroksidasi lipid, gangguan homeostasis Ca2, dan N-acetylcysteine Tanaman Rosmarinus officinalis L. kadang-kadang dikenal sebagai rosemary atau rosmarin, merupakan anggota famili Lamiaceae dan rosemary memiliki efek antioksidan serta hepatoprotektif. Tujuan: Studi ini untuk menguji efektivitas antioxidant ekstrak Rosemary dan sebagai agen hepatoprotektor pada tikus jantan putih. Metode: Penelitian ini dilakukakan secara eksperimental dengan melakukan  ekstraksi etanol 80% Rosemary untuk menguji efektivitas antioksidan yang diujikan kepada hewan tikus 30 ekor terbagi menjadi 6 kelompok dan terdiri dari 5 ekor tikus yang masing-masing hanya di induksi karbon tertaklorida (CCL4): induksi CCL4 & obat pembanding; induksi CCL4  dan ekstrak rosemary dosis 80%, 100% dan 120% serta tikus yang hanya di beri makan dan minum kemudian untuk mengetahui penurunan dan dosis optimalnya berdasarkan kadar AST (Aspartate Aminotransferase) dan ALT (Alanine Aminotransferase). Hasil : Pengukuran setelah diinduksi CCL4 didapatkan kadar rata-rata AST & ALT masing-masing kelompok 1-6 yaitu 60 & 25,6; 155,8 & 154,6; 165 & 153,2; 149,8 & 139,4; 150,6  &147,2; 168,8 & 151 U/L. Pengukuran kadar AST dan ALT setelah dilakukan pemantauan dan perlakuan pada hari ke 1 berturut-turut yaitu 60 & 25,6; 155,8 & 154,6; 165 & 153,2; 149,8 & 139,4; 150,6 & 147,2; 168,8 & 151 U/L. Pada hari ke 7 yaitu 57,6 & 23; 113,4 & 92,4; 160,2 & 149; 114,4 & 102,8; 118.6 & 88,4; 96 & 84,6 U/L.  Pada hari ke 14 yaitu 57 & 22,4; 60 & 27; 128,2 & 123,4; 103,2 & 56,6; 70 & 38,8; 58,2 23,4 U/L. Kesimpulan: Ekstrak Rosemary berpotensi sebagai Hepatoprotektor karena dapat menurunkan aktivitas kadar ALT dan AST pada tikus putih jantan yang telah diinduksikan CCl4 dengan dosis optimum yang dapat digunakan sebagai hepatoprotektor pada dosis 100-120%.
Evaluasi Kualitas Dan Kuantitas Penggunaan Antibiotik Pada Penderita Demam Tifoid Di Rawat Inap Rs An-Nisa Tangerang Winarni, Gandes; Putri, Annisa Septyana; Aisyah, Rizqa Nur
PHRASE (Pharmaceutical Science) Journal Vol 5, No 2 (2025): Pharmaceutical Science Journal Vol 5 No 2, 2025
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i2.1158

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi and is still a health problem in Indonesia. The rational use of antibiotics can increase the risk of resistance. This study aims to evaluate the quality and quantity of antibiotic use in typhoid fever patients in the inpatient ward of An-Nisa hospital Tangerang. The method used was descriptive research with retrospective data collection from patient medical records. The sample in the study was 67 patients who met the inclusion criteria. The quality of antibiotic use was analyzed using the Gyssens method based on the Kemenkes of 2013 and Permenkes No. 28 of 2021, while the quality of antibiotic use was analyzed using the ATC/DDD (Defined Daily Dose) method based on theWHO DDD values. The results of the study showed that only 12,72 of antibiotic use was rational (category 0), while the rest was irrational, especially in category IIIB (duration of use too short) by 36,99 and category V (no indication) by 7,51%, category IVC (cheaper antibiotic) by 4,62%, category IIB (inappropriate interval) by 4,05% and category IIC (route of administration) by 2,86%. The most commonly used antibiotic was Cefixime with the highest DD/100 patient-days value of 126,57 and followed by Ceftriaxone with a DDD/100 patient-days value of 75,12. The conclusion of this study shows that there is a need to improve the accuracy of antibiotic administration, especially in duration, dose, and indication of use, to prevent the emergence of antibiotic resistance in the future.
Co-Authors Aisyah, Rizqa Nur Ayu Werawati Azzahra, Aristi Dede Komarudin Dian Ratih Laksmitawati Gandes Winarni Gina Aulia Kurniawati, Dewi Indah Nasar, Nur Afni Syariah Neneng Sri Purwaningsih Nur Hasanah Nurwulan Adi Ismaya Ruslihagi, Farid Sahat Saragi Sayyidah, Sayyidah Siva Fauziah, Siva Yulis Adriana