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Shufyani , Fahma
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Pengaruh penambahan ekstrak kental daun kelapa sawit (Elaeis Guineensis Jacq.) terhadap viskositas krim tabir surya antijerawat Dominica, Dwi; Putri , Yona Harianti; Versita , Riana; Shufyani , Fahma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.729

Abstract

Introduction: ROS due to sun exposure can damage the skin. Skin structures that are damaged or thinned cause the risk of acne on the skin, one of which is that the skin can be infected with acne-causing bacteria. Palm leaf (Elaeis guineensis Jacq.) is one of the plants that has good antioxidants and antibacterial. The aim: This study aims to determine the effect of the addition of extracts on the viscosity of anti-acne sunscreen creams. Methods: This study was experimental by conducting a viscosity test of sunscreen preparations using a brokfield viscometer. The results of this study show that Formula F1 (1.5%) has the highest viscosity of 8,970 cPs, followed by F2 (3%) at 7890 cPs, and F3 (4.5%) at 7090 cPs which is included in the good viscosity range. Sunscreen creams have pseudoplastic flow properties. Conclusion: the higher the concentration of the extract, the greater the viscosity of the preparation.
Analisis docking tanaman meniran (Phyllanthus niruri L.) terhadap penghambatan asetilkolinesterase penyakit alzheimer Silalahi , Ali Affan; Shufyani , Fahma; Siregar , Syati Manaharawan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.731

Abstract

Meniran plants (Phyllanthus niruri L.) are plants of the Phyllanthus genus. It is known that Phyllanthus genus plants contain astragaline, phyllanthine, hypopyllanthin compounds. Which is a flavonoid derivative that can function as an inhibitor of acetylcholinesterase enzyme against Alzheimer's disease. Based on the results of molecular docking, astragaline compounds have the best binding affinity compared to other compounds, namely -8.4 kcal/mol while the nativ ligand is -5.8 or in other words astragaline compounds derived from meniran plants (Phyllanthus niruri L.) can react when the drug binds to the target receptor in Alzheimer's disease. This type of research aims to determine the potential of compounds from the meniran plant (Phylanthus niruri L.) by inhibiting acetylcholinesterase in Alzheimer's disease. This study used molecular docking method with autodock vina program and visualized with discovery studio program. The conclusion of the study can be seen from the results of docking visualization which shows the form of hydrogen conventional that dominates the hydropobic bond. The interaction that occurs on the active side of the protein indicates that the compound has the ability. In other words, the compound can react as a drug when it binds to the target receptor in Alzheimer's disease.
Co-Authors Dominica, Dwi Putri , Yona Harianti Silalahi , Ali Affan Siregar , Syati Manaharawan Versita , Riana