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Siregar , Syati Manaharawan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Analisi manajemen pengetahuan terhadap kepatuhan minum obat pada pasien hipertensi di apotek Medan central care pharmacy Shufyani, Fahma; Siregar , Syati Manaharawan; Yulia , Rahma
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.572

Abstract

Introduction: Hypertension is one of the most dangerous health problems in the world, because hypertension is the main risk factor that leads to cardiovascular disease such as heart attack, heart failure, stroke and kidney disease. The aim of this study was to determine the relationship between level of knowledge and adherence to taking medication in hypertensive patients at the Medan Central Care Pharmacy.. This Method This research method uses quantitative descriptive analytical methods using a cross-sectional design. The sampling technique uses purposive sampling technique. Data were analyzed using the Chi Square test. Data collection was carried out in June 2023. The research population was hypertension sufferers at the Medan Central Care Pharmacy. The sample for this research was 97 respondent. The results of this study showed that the frequency distribution of high knowledge was 45 respondents (46.4%), medium was 36 respondents (37.1%) and low was 16 respondents (16.5%). The frequency distribution of medication adherence was 19 respondents (19.6%) high, 45 respondents (46.4%) medium and 33 respondents (34%) low. The results of the chi-square test of knowledge with medication adherence showed a p-value of 0.000<0.05. The conclusion in this study is that the respondent's level of knowledge about hypertension is in the high category, the respondent's level of medication adherence is in the medium category and there is a relationship between the level of knowledge and medication adherence in hypertension patients at the Medan Central Care Pharmacy.
Analisis docking tanaman meniran (Phyllanthus niruri L.) terhadap penghambatan asetilkolinesterase penyakit alzheimer Silalahi , Ali Affan; Shufyani , Fahma; Siregar , Syati Manaharawan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.731

Abstract

Meniran plants (Phyllanthus niruri L.) are plants of the Phyllanthus genus. It is known that Phyllanthus genus plants contain astragaline, phyllanthine, hypopyllanthin compounds. Which is a flavonoid derivative that can function as an inhibitor of acetylcholinesterase enzyme against Alzheimer's disease. Based on the results of molecular docking, astragaline compounds have the best binding affinity compared to other compounds, namely -8.4 kcal/mol while the nativ ligand is -5.8 or in other words astragaline compounds derived from meniran plants (Phyllanthus niruri L.) can react when the drug binds to the target receptor in Alzheimer's disease. This type of research aims to determine the potential of compounds from the meniran plant (Phylanthus niruri L.) by inhibiting acetylcholinesterase in Alzheimer's disease. This study used molecular docking method with autodock vina program and visualized with discovery studio program. The conclusion of the study can be seen from the results of docking visualization which shows the form of hydrogen conventional that dominates the hydropobic bond. The interaction that occurs on the active side of the protein indicates that the compound has the ability. In other words, the compound can react as a drug when it binds to the target receptor in Alzheimer's disease.
Co-Authors Shufyani , Fahma Shufyani, Fahma Silalahi , Ali Affan Yulia , Rahma