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Formulasi salep sari batang daun talas (Colocasia esculenta L. ) schoot pada penyembuhan luka sayat pada tikus putih jantan (Rattus norvegicus) Ardiani, Rani; Shufyani, Fahma; Siregar, Syati Manaharawan; Silalahi , Ali Affan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.730

Abstract

Introduction: Taro contains several compounds that can accelerate wound healing, such as flavonoids, phenols, and saponins. These compounds act as natural antibiotics, cleansing wounds with their antibacterial and antifungal properties. Therefore, this plant can aid in the wound healing process. Tannins, on the other hand, have the ability to constrict blood vessels and reduce bleeding in the wound area, decrease infection, and aid in wound healing during the inflammatory phase. One of the wound healing factors, vitamin C helps strengthen the walls of blood vessels, especially in the injured area, to maintain blood supply there and assist in accelerating collagen synthesis during the wound healing process. Lectin, a substance that can accelerate wound closure by aiding better cell regeneration. Arecaceae plants have many benefits for society, such as being used as a food source by harvesting their tubers, or being used as ornamental plants that beautify yards. Taro is also used as medicine both internally and externally. Almost all parts of the taro plant are processed into medicines, and the tubers, stem bark, and roots are crushed and then applied to the skin to heal wounds or bruises. Objective: This study aims to determine the wound healing effects of the sap from the taro stem (Colocasia esculenta L) Schott on male rats (Rattus norvegicus). Method: This study uses an experimental method, which includes sampling, preparation of taro leaf stem extract with concentrations of 2%, 4%, 6%, ointment evaluation test, and incision wound healing activity test on white rats grouped into 5 groups, each consisting of 3 rats. Statistical analysis includes one-way ANOVA to see if there is a significant difference between concentrations in the healing of incisional wounds in male white rats. Result: The research conducted shows that F1 (2% concentration) can heal the rats on the 10th day. F2 (4% concentration) the rats healed on the 8th day, F3 (6% concentration) the cut wounds healed on the 7th day, positive control (Betadine ointment) all rats healed on the 7th day. Conclusion: The extract of taro leaf stems (Colocasia esculenta L) Schoot can be formulated into an ointment preparation for the healing of incised wounds in male white rats (Rattus norvegicus), with the most effective concentration being 6% because it can heal incised wounds the fastest among the other concentrations.
Analisis docking tanaman meniran (Phyllanthus niruri L.) terhadap penghambatan asetilkolinesterase penyakit alzheimer Silalahi , Ali Affan; Shufyani , Fahma; Siregar , Syati Manaharawan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.731

Abstract

Meniran plants (Phyllanthus niruri L.) are plants of the Phyllanthus genus. It is known that Phyllanthus genus plants contain astragaline, phyllanthine, hypopyllanthin compounds. Which is a flavonoid derivative that can function as an inhibitor of acetylcholinesterase enzyme against Alzheimer's disease. Based on the results of molecular docking, astragaline compounds have the best binding affinity compared to other compounds, namely -8.4 kcal/mol while the nativ ligand is -5.8 or in other words astragaline compounds derived from meniran plants (Phyllanthus niruri L.) can react when the drug binds to the target receptor in Alzheimer's disease. This type of research aims to determine the potential of compounds from the meniran plant (Phylanthus niruri L.) by inhibiting acetylcholinesterase in Alzheimer's disease. This study used molecular docking method with autodock vina program and visualized with discovery studio program. The conclusion of the study can be seen from the results of docking visualization which shows the form of hydrogen conventional that dominates the hydropobic bond. The interaction that occurs on the active side of the protein indicates that the compound has the ability. In other words, the compound can react as a drug when it binds to the target receptor in Alzheimer's disease.