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All Journal International Journal Of Public Health International Journal Of Health And Social Behavior International Journal of Health and Medicine
Akpe P. E
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Health Professions Medicine & Pharmacology Nursing Public Health

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Predictive Role of Angle of Deviation, QRS Complex RVH, LVH and T Wave Amplitudes in Preeclamptic Pregnant Women in The Third Trimester of Pregnancy Edebiri O.E; Nwankwo A. A; Akpe P. E; Mbanaso E.L; Obiesi C. N; Chukwu J.A.O
International Journal of Public Health Vol. 2 No. 1 (2025): March : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i1.326

Abstract

The use of ECG patterns as predictors of preeclampsia offers a promising approach, as it is a widely available and cost-effective tool. Specific ECG patterns, including angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes as a potential tool for predicting preeclampsia. The aim of this study is to investigate the predictive role of angle of deviation, QRS Complex (Right Ventricular Hypertrophy (RVH) , Left Ventricular Hypertrophy (LVH)), and T wave amplitudes in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. Results from this present study show no significant differences were observed in QRS complex angles related to right ventricular hypertrophy (RVH) between normotensive and preeclamptic pregnant women. Notably, there was a significant increase in QRS complex related to left ventricular hypertrophy (LVH) in preeclamptic pregnant women, indicating left ventricular remodeling's importance. Moreover, there was a significant increase in T wave amplitude, this suggests underlying myocardial electrical remodeling or dysfunction in preeclampsia, emphasizing the need for cardiovascular monitoring. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection.
Predictive Role of PR Segment, Q Wave Duration and Amplitude, ST Segment, U Wave and Sinus Rhythm in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Nwankwo A. A; Akpe P. E; Mbanaso E.L; Obiesi C. N; Chukwu J.A.O
International Journal of Health and Social Behavior Vol. 2 No. 1 (2025): February: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v2i1.325

Abstract

Early detection and prediction of preeclampsia are crucial to prevent severe complications and ensure timely interventions, Specific ECG patterns, including PR segment, Q wave duration and amplitude, ST segment, U wave, and sinus rhythm were under study for their potential indicators of preeclampsia. This study aims to investigate the predictive role of these ECG patterns in preeclamptic pregnant women in the third trimester of pregnancy. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. results from this present study show no significant differences were observed in the P-R segment, R-R interval, Q wave duration, Q wave amplitude The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection, risk stratification, and management of the condition, despite parameters showing no significant differences. However, PR Segment, Q Wave duration and amplitude, ST Segment , U wave and Sinus rhythm cannot be used to predict preeclampsia
Predictive Role of P Wave Duration, Amplitudes and P Wave Morphology in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Nwankwo A. A; Akpe P. E; Mbanaso E.L; Obiesi C. N; Orunta E.D
International Journal of Health and Medicine Vol. 2 No. 2 (2025): April : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i2.321

Abstract

The ultimate goal of predicting preeclampsia that can enhance early detection and risk stratification in pregnant women, by leveraging the diagnostic potential of ECG patterns, we hope to improve maternal and fetal outcomes and contribute to the development of personalized care strategies for preeclamptic patients. Current diagnostic methods for preeclampsia rely primarily on routine blood pressure monitoring and proteinuria assessment, which have limited sensitivity and specificity. The aim of this study is to investigate the predictive role of P wave duration, amplitudes and morphology in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. Results from this present study show statistically significant increases in P wave duration, amplitude and abnormal M pattern among preeclamptic compare to normotensive pregnant women, consistent with prior research, abnormal M pattern in P wave morphology is linked to atrial pathology in preeclampsia. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection, risk stratification, and management of the condition.
Promising Predictors of preeclampsia Creatinine Kinase and Tyrosine Kinase 1 in preeclamptic pregnant women in the third trimester of pregnancy Edebiri O.E; Nwankwo A.A; Akpe P. E; Mbanaso E.I; Onwuka K. C; Ohiwerei W.O; Omende K
International Journal of Health and Social Behavior Vol. 2 No. 2 (2025): May: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v2i2.366

Abstract

The potential of cardiac markers in predicting preeclampsia, such as Creatinine Kinase (CK) and Tyrosine Kinase 1 (TK1), has emerged as promising due to their involvement in the pathophysiology of this pregnancy complication. Preeclampsia is characterized by hypertension and organ dysfunction, and it can lead to significant maternal and fetal morbidity if not detected early. Early identification of preeclampsia is critical for preventing severe complications, and biomarkers like CK and TK1 can provide valuable insights. This study aimed to investigate the role of CK and TK1 as potential predictors of preeclampsia in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Participants were divided into two groups: twenty (20) normotensive pregnant women and twenty (20) preeclamptic pregnant women in their third trimester. Blood samples were collected and processed using a bucket centrifuge at 2500 RPM for 10 minutes, and plasma was stored frozen for further analysis. Tyrosine Kinase 1 was analyzed by fluorescence immunoassay, and Creatinine Kinase was measured using a spectrophotometric method. Data obtained were analyzed using GraphPad Prism 9, with results expressed as mean ± SEM. Statistical significance was set at a P-value of ≤ 0.05. The study found a statistically significant increase in the levels of both CK and TK1 in preeclamptic women compared to normotensive controls. These findings suggest that CK and TK1 could serve as predictive biomarkers for identifying and monitoring preeclampsia, aiding in early diagnosis and timely interventions
Co-Authors Chukwu J.A.O Edebiri O.E Mbanaso E.I Mbanaso E.L Nwankwo A. A Nwankwo A.A Obiesi C. N Ohiwerei W.O Omende K Onwuka K. C Orunta E.D