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All Journal International Journal of Medicine and Health International Journal of Health and Medicine
Orunta E.D
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Health Professions Medicine & Pharmacology Nursing Public Health

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Predictive Role of P Wave Duration, Amplitudes and P Wave Morphology in Preeclamptic Pregnant Women in the Third Trimester of Pregnancy Edebiri O.E; Nwankwo A. A; Akpe P. E; Mbanaso E.L; Obiesi C. N; Orunta E.D
International Journal of Health and Medicine Vol. 2 No. 2 (2025): April : International Journal of Health and Medicine
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhm.v2i2.321

Abstract

The ultimate goal of predicting preeclampsia that can enhance early detection and risk stratification in pregnant women, by leveraging the diagnostic potential of ECG patterns, we hope to improve maternal and fetal outcomes and contribute to the development of personalized care strategies for preeclamptic patients. Current diagnostic methods for preeclampsia rely primarily on routine blood pressure monitoring and proteinuria assessment, which have limited sensitivity and specificity. The aim of this study is to investigate the predictive role of P wave duration, amplitudes and morphology in preeclamptic pregnant women during the third trimester. Fourty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. These subjects consisted of twenty (20) normotensive and twenty (20) preeclamptic pregnant women in their third trimester of pregnancy. After the subjects were identified and recruited into the study, they were taken to the laboratory where their vital signs was taken and their ECG patterns recorded with ECG machine. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. Results from this present study show statistically significant increases in P wave duration, amplitude and abnormal M pattern among preeclamptic compare to normotensive pregnant women, consistent with prior research, abnormal M pattern in P wave morphology is linked to atrial pathology in preeclampsia. The study underscores the multifactorial nature of cardiovascular changes in preeclampsia and highlights the potential of ECG parameters in aiding early detection, risk stratification, and management of the condition.
Evaluation Of Liver Enzymes (ALP, ALT, AST and GGT) in Preeclamptic Pregnant Women in the Third Trimester Of Pregnancy Edebiri O.E; Adewole A.S; Akpe C. I; Ehigiamusoe E. A; Ikuenobe V. E; Ohiwerei W.O; Orunta E.D
International Journal of Medicine and Health Vol. 4 No. 1 (2025): International Journal of Medicine and Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v4i1.5618

Abstract

Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Aspartate Transaminase (AST), and Gamma-Glutamyl Transferase (GGT) are liver enzymes commonly associated with liver dysfunction, and increased or decreased levels of these enzymes may be implicated in the pathophysiology of preeclampsia. This study aims to evaluate the levels of liver enzymes (ALP, ALT, AST, and GGT) in preeclamptic pregnant women in the third trimester of pregnancy. By analyzing these enzymes, the research seeks to identify potential early indicators of preeclampsia. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples were spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes, after which plasma was collected and stored frozen in plain sample bottles to be analyzed for liver enzymes (ALP, ALT, AST, and GGT) levels using the spectrophotometric method. Data obtained from the study were analyzed using Graph Pad Prism 9. Results were expressed as mean ± SEM, and a P-value of ≤ 0.05 was considered statistically significant. The present study showed a statistically significant increase in ALP, and a statistically significant decrease in liver enzymes such as ALT and AST were observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as liver dysfunction.
Co-Authors Adewole A.S Akpe C. I Akpe P. E Edebiri O.E Ehigiamusoe E. A Ikuenobe V. E Mbanaso E.L Nwankwo A. A Obiesi C. N Ohiwerei W.O