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All Journal International Journal of Medicine and Health International Journal Of Public Health International Journal Of Health And Social Behavior Green Health: Journal of Health Sciences, Nursing and Nutrition
Ohiwerei W.O
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Health Professions Nursing Public Health

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Predictive Role Of Oxidative Stress Biomarkers (Malondialdehyde, Glutathione, Catalase and Superoxide Dismutase) in Preeclamptic Pregnant Women In The Third Trimester Of Pregnancy Edebiri O.E; Akpe C. I; Adewole A.S; Onwuka K; Obiesi C. N Nze P.O; Ohiwerei W.O
International Journal of Public Health Vol. 1 No. 4 (2024): December : International Journal of Public Health
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijph.v2i1.365

Abstract

The predictive role of oxidative stress in the pathophysiology of human pregnancy is of particular interest, as oxidative stress is increased in normotensive pregnant women through systemic inflammatory response, reactive oxygen species (ROS), and reactive nitrogen species (RNS). This study involved 40 consenting pregnant women recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Data obtained were analyzed using GraphPad Prism 9. Results were expressed as mean ± SEM, with a P-value of ≤ 0.05 considered statistically significant. Malondialdehyde (MDA) increased from 3.75 ± 0.42 U/L in normotensive women to 4.53 ± 0.59 U/L in preeclamptic women. However, this increase was not statistically significant (p<0.05; 0.2903). Catalase activity decreased from 114 ± 8.07 U/L in normotensive women to 84.02 ± 21.58 U/L in preeclamptic women, but this decrease was also not statistically significant (p<0.05; 0.1909). Superoxide dismutase (SOD) increased from 40.82 ± 1.23 U/L in normotensive women to 71.90 ± 5.61 U/L in preeclamptic women. This increase was statistically significant (p<0.05; <0.0001). Glutathione peroxidase (GSH) decreased from 66.74 ± 10.35 U/L in normotensive women to 50.63 ± 8.96 U/L in preeclamptic women, but this decrease was not statistically significant (p<0.05; 0.2466). These findings suggest the potential predictive roles of these biomarkers in identifying and monitoring preeclampsia.
Promising Predictors of preeclampsia Creatinine Kinase and Tyrosine Kinase 1 in preeclamptic pregnant women in the third trimester of pregnancy Edebiri O.E; Nwankwo A.A; Akpe P. E; Mbanaso E.I; Onwuka K. C; Ohiwerei W.O; Omende K
International Journal of Health and Social Behavior Vol. 2 No. 2 (2025): May: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v2i2.366

Abstract

The potential of cardiac markers in predicting preeclampsia, such as Creatinine Kinase (CK) and Tyrosine Kinase 1 (TK1), has emerged as promising due to their involvement in the pathophysiology of this pregnancy complication. Preeclampsia is characterized by hypertension and organ dysfunction, and it can lead to significant maternal and fetal morbidity if not detected early. Early identification of preeclampsia is critical for preventing severe complications, and biomarkers like CK and TK1 can provide valuable insights. This study aimed to investigate the role of CK and TK1 as potential predictors of preeclampsia in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Participants were divided into two groups: twenty (20) normotensive pregnant women and twenty (20) preeclamptic pregnant women in their third trimester. Blood samples were collected and processed using a bucket centrifuge at 2500 RPM for 10 minutes, and plasma was stored frozen for further analysis. Tyrosine Kinase 1 was analyzed by fluorescence immunoassay, and Creatinine Kinase was measured using a spectrophotometric method. Data obtained were analyzed using GraphPad Prism 9, with results expressed as mean ± SEM. Statistical significance was set at a P-value of ≤ 0.05. The study found a statistically significant increase in the levels of both CK and TK1 in preeclamptic women compared to normotensive controls. These findings suggest that CK and TK1 could serve as predictive biomarkers for identifying and monitoring preeclampsia, aiding in early diagnosis and timely interventions
Evaluation Of Liver Enzymes (ALP, ALT, AST and GGT) in Preeclamptic Pregnant Women in the Third Trimester Of Pregnancy Edebiri O.E; Adewole A.S; Akpe C. I; Ehigiamusoe E. A; Ikuenobe V. E; Ohiwerei W.O; Orunta E.D
International Journal of Medicine and Health Vol. 4 No. 1 (2025): International Journal of Medicine and Health
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v4i1.5618

Abstract

Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Aspartate Transaminase (AST), and Gamma-Glutamyl Transferase (GGT) are liver enzymes commonly associated with liver dysfunction, and increased or decreased levels of these enzymes may be implicated in the pathophysiology of preeclampsia. This study aims to evaluate the levels of liver enzymes (ALP, ALT, AST, and GGT) in preeclamptic pregnant women in the third trimester of pregnancy. By analyzing these enzymes, the research seeks to identify potential early indicators of preeclampsia. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples were spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes, after which plasma was collected and stored frozen in plain sample bottles to be analyzed for liver enzymes (ALP, ALT, AST, and GGT) levels using the spectrophotometric method. Data obtained from the study were analyzed using Graph Pad Prism 9. Results were expressed as mean ± SEM, and a P-value of ≤ 0.05 was considered statistically significant. The present study showed a statistically significant increase in ALP, and a statistically significant decrease in liver enzymes such as ALT and AST were observed in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes such as liver dysfunction.
Promising Markers of Preeclampsia : Cardiac Troponin 1 and Brain Natriuretic Peptide in Third Trimester Pregnant Women Edebiri O.E.; Nwankwo A. A.; Akpe P. E.; Mbanaso E.L.; Ikuenobe V. E.; Omende K.; Ohiwerei W.O
Green Health International Journal of Health Sciences Nursing and Nutrition Vol. 2 No. 2 (2025): Green Health: International Journal of Health Sciences, Nursing and Nutrition
Publisher : International Forum of Researchers and Lecturers

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70062/greenhealth.v2i2.143

Abstract

Cardiac Troponin1 (cTn1) is a protein released into the bloodstream following cardiac damage and Brain Natriuretic Peptide (BNP) is a hormone released by the heart in response to ventricular stretch and pressure overload. This study aims to investigate the predictive role of cTn1 and BNP in preeclamptic pregnant women in the third trimester of pregnancy. Forty (40) consenting pregnant women were recruited from St. Philomina Catholic Hospital, Edo State, Nigeria. Blood samples was spun in a bucket centrifuge at 2500 RPM (rounds per minute) for 10 minutes after which plasma was collected and stored frozen in plain sample bottles and was analyzed for Cardiac Troponin 1(cTn1) and Brain Natriuretic Peptide (BNP) by fluorescence immunoassay. Data obtained from this study were analysed using Graph Pad Prism 9. Results generated were expressed as mean ± SEM and a P-value of ≤ 0.05 were considered statistically significant. The present study showed that there was statistically significant increase in Brain Natriuretic Peptide (BNP) in preeclamptic women compared to normotensive pregnant women, indicating various underlying pathophysiological processes. These findings suggest the potential predictive roles of this cardiac marker in identifying and monitoring preeclampsia.
Co-Authors Adewole A.S Akpe C. I Akpe P. E Akpe P. E. Edebiri O.E Edebiri O.E. Ehigiamusoe E. A Ikuenobe V. E Ikuenobe V. E. Mbanaso E.I Mbanaso E.L. Nwankwo A. A. Nwankwo A.A Obiesi C. N Nze P.O Omende K Omende K. Onwuka K Onwuka K. C Orunta E.D