Hypertension is one of the important public health problems in Indonesia, which contributes to the high prevalence of non-communicable diseases. This study aims to model the prevalence of hypertension in Indonesia using the Multivariate Adaptive Regression Splines (MARS) method to identify significant predictors and their interactions. The data used was secondary data from the 2023 Indonesian Health Survey, including variables such as smoking prevalence, physical inactivity, dietary habits (consumption of fatty and sweet foods), lack of fruit and vegetable consumption, and obesity prevalence. The MARS method was used to analyse the nonlinear relationships and interactions between these predictors. After a trial-and-error process to determine the optimal number of basis functions (BF), maximum interactions (MI), and minimum observations (MO), the best model was achieved with BF = 18, MI = 3, and MO = 1. This model produced a Generalised Cross Validation (GCV) value of 13.428 and R-Square of 0.278. This fairly low R-Square value indicates that the factors analysed have contributed to the variation in hypertension prevalence, but there are still other aspects that can be taken into account to improve the predictive power of the model. The significant predictor variables were consumption of fatty foods (X3), lack of physical activity (X2), and consumption of sweets (X4), with the highest importance on X3 (100%). The findings reveal that interactions between variables, such as dietary habits and physical inactivity, significantly influence the prevalence of hypertension. For example, higher consumption of fatty and sweet foods combined with low physical activity increases the risk of hypertension. These results demonstrate the effectiveness of the MARS method in capturing complex and nonlinear relationships and serve as findings that highlight the need for health policies that focus on healthy diets and increased physical activity, in line with Goal 3 of the SDGs, “Good Health and Well-Being,” which aims to reduce premature mortality from noncommunicable diseases. Recommended interventions include nutrition education campaigns and community-based exercise programs to reduce the prevalence of hypertension in Indonesia.