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All Journal Jurnal Respirologi Indonesia Majalah Patologi Indonesia
Dameria, Flora
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Health Professions Medicine & Pharmacology Public Health

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Klinikopatologik dan Profil Imunohistokimia Primary Mediastinal Large B-cell Lymphoma dan Limfoma Hodgkin Nodular Sclerosis di Regio Mediastinum Dameria, Flora; Francisca Ham, Maria; Stephanie Harahap, Agnes
Majalah Patologi Indonesia Vol. 32 No. 1, Januari 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i1.565

Abstract

Background Primary mediastinal large B-cell lymphoma (PMBCL) and Hodgkin nodular sclerosis (LHNS) lymphoma was the most common lymphomas involved the mediastinum. These two lymphomas had similar histopathological features. The purpose of this study was to analyzed clinical data, histopathological characteristics, and immunohistochemistry (IHC) profiles on PMBCL and LHNS. Methods This is a retrospective study. Data was collected from archive of Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital in 2014-2020. The data collected included clinical data, hematoxylin-eosin (HE) and IHC slides and were reassessed by the researcher and supervisor. The histopathological characteristics data was analyzed statistically using statistical package for the social sciences version 25.0 with Chi-Square test. Results PMBCL and LHNS have similar histopathological features, included the characteristics of tumor cells and infiltration of many fibrosis and inflammatory cells, but difference in architecture, tumor cell types, clear cytoplasmic tumor cells, inflammatory cell and fibrosis types, with p value <0.001. The characterized differences of PMBCL showed diffuse architecture, some cells with RS-like cell structure, clear/pale cytoplasm, lymphocyte cell infiltration, and compartmental fibrosis. Whilst, LHNS showed nodular architecture, Reed Sternberg cells, mixed inflammatory cell infiltration, and band-like fibrosis. PMBCL showed CD20, PAX5, MUM1 strongly positive, CD30 weakly positive, and CD15 negative, while LHNS showed negative CD20, CD30 and MUM1 strongly positive, PAX5 weakly positive, and CD15 positive.
Comparison Between Imprint Cytology and Histopathology Results in Pleural Effusion Cases Undergoing Pleuroscopy Aniwidyaningsih, Wahju; Dameria, Flora; Rahardjo, Eylin; Beginta, Romi; Sembiring, Ruth Emalian; Rasmin, Menaldi; Reisa, Tina; Arum, Ginanjar; Elhidsi, Mia; Prasenohadi; Fahmi, Muhammad; Soehardiman, Dicky; Utami, Dian Prastiti; Martini, Ni Putu Laksmi Ananda
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/j57hm670

Abstract

Background: Pleuroscopy is a valuable minimally invasive procedure for evaluating undiagnosed pleural effusion. Rapid diagnosis of malignancy is often needed to reduce procedure time and patient discomfort, particßularly when pleurodesis is planned. Imprint cytology is a quick and simple method, though underutilized in pleuroscopy practice in Indonesia. This study aims to compare the diagnostic yield of imprint cytology and histopathology in pleural effusion cases undergoing pleuroscopy. Methods: This observational cross-sectional study was conducted in September–October 2024, involving patients with pleural effusion who underwent diagnostic pleuroscopy. Pleural biopsies were taken using forceps. Imprint cytology was performed by directly smearing the biopsy tissue onto slides, followed by staining. Histopathology was done using standard tissue processing. Results: Of the 25 patients who underwent pleuroscopy during September–October 2024, 14 met the inclusion criteria. Pleuroscopic findings varied, with the most common being lump of mass (35.7%), followed by multiple nodules (21.4%) and sago nodules (14.3%). Histopathology revealed malignancy in 10 patients (71.4%) and nonspecific inflammation in 4 (28.6%). Imprint cytology detected malignancy in 12 patients (85.7%) and infection in 2 (14.3%).   Conclusion: Imprint cytology offers a rapid, reliable alternative to frozen section analysis during pleuroscopy, especially in resource-limited settings. It may increase diagnostic sensitivity for malignancy and facilitate timely clinical decision-making.
Co-Authors Aniwidyaningsih, Wahju Arum, Ginanjar Beginta, Romi Elhidsi, Mia Francisca Ham, Maria Martini, Ni Putu Laksmi Ananda Menaldi Rasmin MUHAMMAD FAHMI Prasenohadi Rahardjo, Eylin Reisa, Tina Sembiring, Ruth Emalian Soehardiman, Dicky Stephanie Harahap, Agnes Utami, Dian Prastiti