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All Journal International Journal of Health and Pharmaceutical (IJHP)
Claudia Malau, Reghita
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Nursing Public Health

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The Effect of Giving Coffee Pulp Extract Cream on the Healing of Cut Wounds in Wistar Rats Juita, Anggun; Ikhtiari, Refi; Tandanu, Erny; Claudia Malau, Reghita
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 1 (2025): February 2025 (Indonesia - Turkey - Malaysia - Australia - Iran)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i1.409

Abstract

Humans need skin to protect their internal organs, such as muscles, nerves, and bones, from disease. This study examines the effect of coffee grounds extract cream on wound healing in Wistar rats. This study is an experimental laboratory study. The research design used a post-test with a control group design or control on samples based on treatment groups to analyze the effect of coffee grounds extract on wound healing and skin histopathology in male Wistar white rats. According to the results of the study, coffee grounds extract accelerated wound healing in Wistar white rats, as shown by the average differences of 2.5%, 5%, and 10%. This study shows that coffee grounds extract contains saponins, alkaloids, flavonoids, and tannins. Research on skin histopathology on the best fibroblast tissue found that 10% coffee grounds extract cream was the most helpful in developing connective tissue in injured skin. The findings of this study are expected to help other researchers explore the effects of coffee grounds extract on skin collagen formation.
An Effect Of Methanol Extract Sunkist Orange Peel (Citrus Sinensis (L.) Osbeck) On Blood Sugar And Cholesterol Levels Wistar Rats (Rattus Norvegicus) Induced By Aloxan Eliza Putri Lubis, Yolanda; Claudia Malau, Reghita; Arianti, Rahmi; Sari Mutia, Maya
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 2 (2023): May 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v3i3.117

Abstract

Insulin resistance is a condition with damage to target organs that generally respond to the activity of the hormone insulin. About 10% of the population in big cities in Indonesia suffer from insulin resistance. At the cellular level, insulin resistance can result from damage to the pre-receptor, receptor, or post-receptor. The most common cause of insulin resistance is post-receptor damage, namely disruption and damage to insulin signaling pathways. To find out that the methanol extract of Sunkist orange peel can reduce blood sugar levels in Wistar rats. This research uses the experimental laboratory method in vivo with the chosen research design form, namely True Experimental Pre Test and Post Test Control. The Kruskal Wallis test showed that the Sunkist Orange Peel Methanol Extract resulted in a significant decrease in blood sugar levels of Wistar rats with a p-value <0.05, and also the Anova test showed that the Sunkist Orange Peel Methanol Extract resulted in a decrease in blood sugar levels of Wistar rats, which is significant with p-value <0.05. All doses tested affect lowering blood sugar levels, namely, 300 mg/kg BW, 450 mg/kg BW, and 600 mg/kg BW.
Co-Authors Arianti, Rahmi IKHTIARI, REFI Juita, Anggun Sari Mutia, Maya Tandanu, Erny Yolanda Eliza Putri Lubis