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All Journal Journal of Epidemiology and Public Health Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Ichsan, Burhannuddin
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Computer Science & IT Engineering Medicine & Pharmacology Public Health Social Sciences Other

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Meta-Analysis: The Effect of D-Dimer on Mortality in Patients with COVID-19 Ryadi, Yusuf; Rahardjo, Setyo Sri; Ichsan, Burhannuddin
Journal of Epidemiology and Public Health Vol. 7 No. 4 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2022.07.04.11

Abstract

Background: The severity of COVID-19 can be detected by examining elevated levels of CRP, ferritin, IL-6 and LDH. Elevated D-dimer levels are often found in patients with severe COVID-19 which can predict the occurrence of ARDS (Acute Respiratory Distress Syndrome) and patient mortality. The purpose of this study was to determine how much influence D-dimer levels had on mortality of COVID-19 patients. Subjects and Method: This study used a systematic review and meta-analysis with following PICO, population: patients with a clinical diagnosis of COVID-19. Intervention: high D-dimer level. Comparison: low D-dimer level. Outcome: mortality. The data used were obtained from scientific research articles from Pubmed, Google Scholar, Science Direct, and Proquest electronic databases with a cohort design in 2020 until 2022 and report on aOR in multivariate analysis. The keywords used in the search for scientific articles were “D-dimer level” OR “D-dimer” AND “COVID-19” AND “mortality”. The selection of articles is done by using PRISMA flow diagram. Data were analyzed using Review Manager software version 5.4.1.Results: A total of 12 studies with a cohort design that met the criteria from Asia, America, and Europe were selected for a systematic review and meta-analysis. Based on the meta-analysis, it was found that increased levels of D-dimer (>0.5 g/mL) increased mortality in COVID-19 patients by 6.40 times compared to low levels of D-dimer (≤0.5 g/mL) and was statistically significant (aOR = 6.40; 95% CI= 4.51 to 9.08; p<0.001).Conclusion: Elevated levels of D-dimer may increase mortality risk in COVID-19 patients. Keywords: d-dimer level, d-dimer, covid-19, mortality. Correspondence:Yusuf Ryadi. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Jawa Tengah. Email: yusuf.ryadi@gmail.com. Mobile: 085715605268.
Hypertension Patients' Perceptions of Healthy Lifestyles and Complications of Hypertension Mahensa, Noval Gentha; Ichsan, Burhannuddin; Lestari, Nining; Soekiswati, Siti
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5529

Abstract

Purpose: This study aims to identify patient perceptions, influencing factors, patient efforts, and increasing compliance with healthy lifestyles in hypertensive patients. Methodology: This study uses a qualitative approach method with a phenomenological design to explore in-depth information based on patient knowledge and understanding. The study was conducted on hypertensive patients from October to November 2024 at the Gatak Health Center. Results: Each patient has the same perception and knowledge about hypertension, but differs in the implementation of a healthy lifestyle and knowledge about complications of hypertension. Most patients agree that hypertension is dangerous and requires the implementation of a good lifestyle to prevent the development of hypertension, but some patients think that hypertension is not dangerous as long as they implement a good and correct healthy lifestyle. If this is put together, it will become the same core, only different in understanding, it is natural that this happens because each patient has a different mindset and understanding. All patients have learned information about hypertension from medical personnel education, television broadcasts, and personal experiences with the motivation of wanting to recover from hypertension. Applications/Originality/Value: Exploring how patients themselves perceive and understand these steps. Knowing the patient's perception will help in designing an educational program that is more targeted and in accordance with their needs and understanding.
Co-Authors Lestari, Nining Mahensa, Noval Gentha Rahardjo, Setyo Sri Siti Soekiswati Yusuf Ryadi