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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Medika Malahayati
Haitamy, Mohammad Nurrizki
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Peran Nigella Sativa Linn. Dalam Mukositis Oral Yang Diinduksi Oleh Kemoradioterapi : Literature Review Hanifia, Resita Nifada; Kadarullah, Oke; Haitamy, Mohammad Nurrizki; Romdhoni, Muhammad Fadhol
Jurnal Medika Malahayati Vol 9, No 1 (2025): Volume 9 Nomor 1
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v9i1.18294

Abstract

Chemoradiation Induced Oral Mucositis (CIOM), merupakan peradangan atau luka lecet di sekitar rongga mulut yang disebabkan oleh efek kemoterapi dan radioterapi. Kemoradioterapi menimbulkan gejala klinis diantaranya nyeri, peradangan, disfagia, diare, penurunan berat badan drastis, dan infeksi. Oleh karena itu, diperlukan upaya pencegahan dan pilihan pengobatan CIOM yang aman dan efektif. Nigella Sativa Linn adalah jintan hitam yang dikenal memiliki sifat anti inflamasi, analgesik, antioksidan, pelindung saraf, pelindung saluran cerna, dan khasiat lainya. Tinjauan literatur ini diidentifikasi menggunakan metode pencarian komprehensif pada basis data elektronik termasuk metodologi uji klinis dengan memasukan kata kunci “kemoterapi”;  “mukositis oral”; “Nigella Sativa”; “radiasi”. Kata kunci ini digunakan untuk mencari artikel terkait melalui website: Pubmed, Scopus, dan Google Scholar. Hasil penelitian menyatakan terdapat peran Nigella Sativa Linn (NSL) terhadap mukositis oral akibat terapi onkologi kemoradioterapi. Didapatkan kesimpulan bahwa NSL  memiliki senyawa aktif thymoquinone yang bertindak sebagai imunomodulator dan anti inflamasi yang efektif dengan menekan sitokin proinflamasi, sehingga NSL secara signifikan dapat membantu meringankan gejala mukositis oral akibat kemoradioterapi.
Exosome Hypoxic-MSCs, Glutathione, and Vitamin C: Effect on IL-10 Levels and CD-163 Expression Utami, Wulan Dyah; Muhar, Adi Muradi; Sumarawati, Titiek; Putra, Agung; Setiawan, Eko; Ibrahim, Sugeng; Taskworo, Dodik; Haitamy, Mohammad Nurrizki
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.60941

Abstract

Hyperpigmentation of the skin is a result of ultraviolet B (UVB) exposure, which causes oxidative stress due to increased reactive oxygen species (ROS), leading to various skin problems, including melanin accumulation. Exosomes can affect melanocyte activity. Exosomes, as small vesicles released by cells, can affect melanocyte activity and play an important role in various hyperpigmentation processes. The study aims to determine the effect of exosome mesenchymal stem cell hypoxia (EH-MSC) and glutathione with vitamin C on IL-10 levels and CD163 expression. IL-10 gene expression was measured using qRT-PCR, while CD163 expression was analyzed via immunohistochemical staining. A total of 30 male C57BL/6 mice were used and randomly assigned to five different treatment groups. The highest expression of IL-10 was observed in the EH-MSCs-treated group (K4), although the difference was not statistically significant compared to the control (p = 0.135). In contrast, the group receiving a combination of EH-MSCs with glutathione and vitamin C (K5) exhibited the highest percentage of CD163 expression, with a statistically significant difference (p = 0.00). These findings demonstrate that the administration of EH-MSC and glutathione with vitamin C significantly increased the expression of CD163, but insignificantly increased IL-10 in C57BL/6 mice with a UVB-induced hyperpigmentation model.
Co-Authors Agung Putra Eko Setiawan Hanifia, Resita Nifada Ibrahim, Sugeng Kadarullah, Oke Muhar, Adi Muradi Romdhoni, Muhammad Fadhol Taskworo, Dodik Titiek Sumarawati Utami, Wulan Dyah